Synthesis and characterization of PEG-PCL-PEG thermosensitive hydrogel

Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

“…Aqueous solutions of these diblock and three-block copolymers resulted to be a free-flowing sol at either room or below the corresponding critical gel temperatures (CGT), and a gel at body temperature. Thus a mice model was applied to evaluate the gel formation and its subsequent degradation followed by subcutaneous injection of PEG-PCL hydrogels ( Figure 5) [103]. In the same work, degradation behavior and drug release behavior of these di-and tri-block copolymers have been investigated.…”

Preventing postoperative abdominal adhesions in a rat model with PEG-PCL-PEG hydrogel

“…11,12 In previous work, the PECE hydrogel was proven to be injectable, biocompatible, and bioabsorbable. 22,23 Results showed that the hydrogel could not only be adhered to the peritoneal wounds even with punctate hemorrhage but also effectively prevent postsurgical intra-abdominal adhesions. The key for preventing adhesions is the reconstruction of the neo-mesothelial cell layer.…”

“…22,27 The M n and PEG/PCL block ratio of PECE triblock copolymer calculated from 1 H-NMR spectra was 3630 and 1100/2530 respectively. FTIR and 1 H-NMR results indicated that PECE triblock copolymer was prepared successfully.…”

“…22 The prepared PECE hydrogels were proved to be thermosensitive, biocompatible, and bioabsorbable. 22,23 In this present study, the aim was to assess its potential anti-adhesion efficacy and mechanisms in a rat model of surgical adhesion formation. Its potential toxicity was also investigated in vivo by histopathological observations.…”

Introductory Chapter: Multi-Aspect Bibliographic Analysis of the Synergy of Technical, Biological and Medical Sciences Concerning Materials and Technologies Used for Medical and Dental Implantable Devices

“…Hydrogels used in tissue engineering should have low viscosity before injection and should be gelling fast in the physiological environment of the tissue, and the most important is gelling (sol-gel transition) by cross-linking, which may take place when producing them in vitro and in vivo during injection. Physical cross-linking is used in particular in the case of poly(N-isopropylacrylamide) (poly(NIPAAM)), which may be used in tissue engineering after introducing acrylic acid (AAc) or PEG [460,461] or biodegradable polymers, including such as chitosan, gelation, hyaluronic acid and dextran [462][463][464][465][466] to block copolymers, such as poly(ethylene oxide) PEO-PPO-PEO (Pluronic), poly(lactide-co-glycolide) PLGA-PEG-PLGA, PEG-PLLA-PEG, polycaprolactone PCL-PEG-PCL and PEG-PCL-PEG [467][468][469][470][471], and also agarose (a polysaccharide polymer material, extracted from seaweed as one of the two principal components of agar) [459], as thermo-sensitive systems [472], to avoid the use of potentially cytotoxic ultraviolet radiation. Poly(NIPAAM) and block copolymer hydrogels may undergo cross-linking as a consequence of temperature and pH acting at the same time, as in the case of acrylates [473,474], such as 2-(dimethylamino)ethyl-methacrylate (DMAEMA) or 2-(diethylaminoethyl) methyl methacrylate.…”