Synthesis and characterization of peptide-imprinted nanogels of controllable size and affinity

Cenci, Lucia; Tatti, Roberta; Tognato, R.; Ambrosi, Emmanuele; Piotto, Chiara; Bossi, Alessandra Maria

doi:10.1016/j.eurpolymj.2018.08.031

Cited by 29 publications

(14 citation statements)

References 51 publications

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“…The presence of this template can impact the polymerization kinetics in different ways, e.g., by forming a complex with the functional monomer, which may alter its reactivity, or by radical scavenging. Thus, the effect of the template on monomer reactivities needs to be carefully examined, although this is often overlooked [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

“…For this reason, detailed studies of monomer reactivities and reaction conditions are essential to ensure that the isolated polymer has a final formulation that is as close as possible to the initial combination of monomers and crosslinker (feed composition). Despite its importance, literature data on radical polymerizations rarely investigate the actual polymer composition and instead limit description to the initial formulation [ 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Covalently Crosslinked Nanogels: An NMR Study of the Effect of Monomer Reactivity on Composition and Structure

et al. 2019

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Covalently crosslinked nanogels are widely explored as drug delivery systems and sensors. Radical polymerization provides a simple, inexpensive, and broadly applicable approach for their preparation, although the random nature of the reaction requires careful study of the final chemical composition. We demonstrate how the different reactivities of the monomers influence the total degree of incorporation into the polymer matrix and the role played by the experimental parameters in maximizing polymerization efficiency. Nanogels based on N-isopropylacrylamide, N-n-propylacrylamide, and acrylamide crosslinked with N,N’-methylenebisacrylamide were included in this study, in combination with functional monomers N-acryloyl-l-proline, 2-acrylamido-2-methyl-1-propanesulfonic acid, and 4-vinyl-1H-imidazole. Total monomer concentration and initiator quantities are determining parameters for maximizing monomer conversions and chemical yields. The results show that the introduction of functional monomers, changes in the chemical structure of the polymerizable unit, and the addition of templating molecules can all have an effect on the polymerization kinetics. This can significantly impact the final composition of the matrices and their chemical structure, which in turn influence the morphology and properties of the nanogels.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Covalently Crosslinked Nanogels: An NMR Study of the Effect of Monomer Reactivity on Composition and Structure

et al. 2019

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“…Acrylic acid H-bonding; electrostatic (−) (42,73,77,(167)(168)(169) Methacrylic acid H-bonding (67,74,76,90,93,105,106,111,140,190,224) Methyl N-tert-butylacrylamide Hydrophobic (73, 77, 90, 93, 96, 117, 167-169, 190, 198, 199, 224) N- [3-(dimethylamino)propyl]methacrylamide Electrostatic (+) (42)…”

Section: Functional Monomer Molecular Interaction(s) Reference(s)mentioning

confidence: 99%

Epitope-imprinted polymers: Design principles of synthetic binding partners for natural biomacromolecules

et al. 2021

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“…Recently, molecularly imprinted nanostructures as biomimetics of natural antibodies were synthesized [11]. Cardiac Troponin I is a protein of 209 amino acids and molecular weight of about 23 kDa.…”

Section: Molecular Imprinting Techniques For Biomimetics 1separation Techniquesmentioning

confidence: 99%

Molecular Imprinting Technology for Biomimetic Assemblies

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et al. 2020

Hacettepe Journal of Biology and Chemistry

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B iyomimetik terimi, kısaca doğanın incelenmesi olarak tanımlanabilir. Bilim adamları biyomedikal ve terapötik uygulamalarda, daha iyi ilaçlar, yapay organlar, algılama aletleri vb. yapmak için doğal modelleri, sistemleri ve unsurları taklit ederek, insan sorunlarını çözmek ve günlük yaşamı kolaylaştırmak için doğanın muazzam çeşitliliğinden ilham aldılar. Bu tür uygulamalarda, stabilite ve tekrar kullanılabilirlikteki eksikliklere rağmen, özgüllüğü sağlamak için proteinler, antikorlar, enzimler, DNA, lektinler, aptamerler, hücreler ve virüsler gibi biyolojik tanıma öğeleri yoğun olarak kullanılmıştır. Bununla birlikte, son yirmi yılda moleküler baskılanmış polimerler (MIP'ler), çapraz bağlayıcının varlığında kalıp yapı etrafında fonksiyonel monomerlerin koordine edilmesi yoluyla geniş bir örnek yelpazesi oluşturmuş ve doğal biyolojik etkileşimleri taklit etmeye bir alternatif olarak sentezlenmiştir. Bu derleme, ayırma tekniklerinde, doku mühendisliği uygulamalarında, biyomimetik yüzeylerde, sensörlerde, yapay membranlar ve ilaç taşınım sistemlerinde moleküler baskılama teknikleriyle hazırlanan biyomimetiklerin genel hatlarını ve pratik uygulamalarını özetleyecektir.

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Synthesis and characterization of peptide-imprinted nanogels of controllable size and affinity

Cited by 29 publications

References 51 publications

Covalently Crosslinked Nanogels: An NMR Study of the Effect of Monomer Reactivity on Composition and Structure

Covalently Crosslinked Nanogels: An NMR Study of the Effect of Monomer Reactivity on Composition and Structure

Epitope-imprinted polymers: Design principles of synthetic binding partners for natural biomacromolecules

Molecular Imprinting Technology for Biomimetic Assemblies

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