Synthesis and characterization of poly[1-(N,N-bis-carboxymethyl)amino-3-allylglycerol-co-dimethylacrylamide] grafted to magnetic nano-particles for extraction and determination of letrozole in biological and pharmaceutical samples

Panahi, Homayon Ahmad; Soltani, Elham; Moniri, Elham; Tamadon, Atefeh

doi:10.1016/j.talanta.2013.09.015

Cited by 27 publications

(3 citation statements)

References 31 publications

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“…In other words, the sorption capacity of drug loading was developed by the presence of CS in grafted polymer chain. The adsorption capacity of sorbent for LE is comparable with our previous work .…”

Section: Introductionsupporting

confidence: 88%

Magnetic iron oxide nanoparticles graftedN-isopropylacrylamide/chitosan copolymer for the extraction and determination of letrozole in human biological samples

Moazen

Panahi

2017

J. Sep. Sci.

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Magnetic iron oxide nanoparticles are used for the extraction of a drug from an aqueous solution. In the current study, the magnetic iron oxide nanoparticles were synthesized via a facile coprecipitation approach, and then modified by (3-mercaptopropyl)trimethoxysilane followed by grafting thermosensitive polymer N-isopropylacrylamide and biopolymer chitosan. Structure, morphology, size, thermal resistance, specific surface area, and magnetic properties of the grafted nanosorbent were characterized by using Fourier transform infrared spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, elemental analysis, thermogravimetric analysis, specific surface area analysis and vibrating sample magnetometry. The effective parameters on sorption/desorption of letrozole on grafted magnetic nanosorbent were evaluated. The best sorption of letrozole via the grafted nanosorbent occurred at 20°C at an optimum pH of 7. The extraction of trace letrozole in human biological fluids is investigated and revealed 89.1 and 97.8% recovery in plasma and urine, respectively.

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Section: Introductionsupporting

confidence: 88%

Magnetic iron oxide nanoparticles graftedN-isopropylacrylamide/chitosan copolymer for the extraction and determination of letrozole in human biological samples

Moazen

Panahi

2017

J. Sep. Sci.

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“…Consequently, determination of this drug in body fluids is really on demand. To date, various analytical methods have been reported for analysis of LTZ in body fluids, mostly based on chromatographic techniques such as HPLC coupled with ultraviolet, fluorescent, MS, or tandem MS detectors [4,27–30]. Usually, along with these techniques, a sample preparation step is performed in order to preconcentrate the LTZ and clean the corresponding matrix.…”

Section: Introductionmentioning

confidence: 99%

“…In this regard, SPME is one of the commonly used pretreatment methods. Up to date, some composite materials were introduced as SPME sorbents for LTZ analysis such as MWCNTs‐resorcinol [26], Fe 3 O 4 /N‐isopropylacrylamide/chitosan copolymer [27], Fe 3 O 4 /poly[1‐(N,N‐bis‐carboxymethyl) amino‐3‐allylglycerol‐co‐dimethylacrylamide] [28], fused silica (C 18 )/Fe 3 O 4 /PEGylated dendrimer [29], and so on. The main limitation of these sorbets are the high number of used reagents, multisteps synthesis approaches, usually prepared at a higher temperature than the ambient condition, time‐consuming sorbent preparation stages, and in the most of them, the sorption and desorption process of LTZ need a long time.…”

Section: Introductionmentioning

confidence: 99%

Electrodeposition of poly‐ethylenedioxythiophene‐graphene oxide nanocomposite in a stainless steel tube for solid‐phase microextraction of letrozole in plasma samples

Ramezani

Yamini

2020

J of Separation Science

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Coated stainless steel was used as an in-tube solid-phase microextraction for the extraction of letrozole from plasma samples. The coating process on the inner surface of the stainless steel was conducted by a simple electrodeposition process. The coated composite was prepared from 3,4-ethylenedioxythiophene and graphene oxide. In this composite, graphene oxide acts as an anion dopant and sorbent. The coated nanostructured polymer was characterized using different techniques. The operational factors affecting the extraction process, including pH, adsorption, and desorption time, the recycling flow rate of the sample solution, sample volume, desorption solvent type and its volume, and ionic strength were optimized to achieve the best extraction efficiency of the analyte. The total extraction time including adsorption and desorption steps was about 15.0 min. The developed method demonstrated a linear range of 5.0-1500.0 μg/L with a limit of detection of 1.0 μg/L. The repeatability of the developed extraction approach in terms of intraday, interday, and fiber to fiber was attained in the range of 4.9-8.3%. After finding the optimal conditions, the potential of the described approach for letrozole quantitation was investigated in plasma samples, and satisfactory results were obtained.

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Extraction Methods Facilitated by the use of Magnetic Nanoparticles

Rocío‐Bautista

Pino

2015

Analytical Separation Science

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Magnetic nanoparticles (MNPs) are a group of nanoparticles (NPs) that present superparamagnetic properties. MNPs are composed of a magnetic solid phase that is responsible for the magnetic properties. The characterization of MNPs is usually accomplished using techniques such as X‐ray diffraction (XRD), transmission electron microscopy (TEM), or scanning electron microscopy (SEM). Several review articles have been recently devoted to MNPs in analytical chemistry and particularly to sample preparation. This chapter presents extraction methods facilitated by the use of MNPs, with particular emphasis on MNP types and extraction applications. The relatively simple tuneability of MNPs, by easily anchoring task‐specific sorbents of quite different nature (silica based, carbon and derivatives based, polymeric based, and so on), opens a number of possible combinations and enormously extends its future applications

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Synthesis and characterization of poly[1-(N,N-bis-carboxymethyl)amino-3-allylglycerol-co-dimethylacrylamide] grafted to magnetic nano-particles for extraction and determination of letrozole in biological and pharmaceutical samples

Cited by 27 publications

References 31 publications

Magnetic iron oxide nanoparticles graftedN-isopropylacrylamide/chitosan copolymer for the extraction and determination of letrozole in human biological samples

Magnetic iron oxide nanoparticles graftedN-isopropylacrylamide/chitosan copolymer for the extraction and determination of letrozole in human biological samples

Electrodeposition of poly‐ethylenedioxythiophene‐graphene oxide nanocomposite in a stainless steel tube for solid‐phase microextraction of letrozole in plasma samples

Extraction Methods Facilitated by the use of Magnetic Nanoparticles

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