Synthesis and characterization of poly-l-lysine grafted SBA-15 using NCA polymerization and click chemistry

Kar, Mrityunjoy; Malvi, Bharmana; Das, Anindita; Panneri, Suyana; Gupta, Sayam Sen

doi:10.1039/c0jm04589f

Cited by 28 publications

(34 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As high as 57.6% monomer conversion could be obtained after 72 hrs polymerization (Entry 7 in Table 1). The grafting ratio of the polymer was reached as high as 27.6%, which was similar as the literature results [36]. Not only the monomer MMA could be grafted onto the surface of SBA-15, but also monomers PDMAEMA and PNIPAM could be grafted onto the surface of SBA-15 (Entries 8 and 9 in Table 1), which implied the various applicable for current method to grafting polymers from the surface of SBA-15.…”

Section: Resultssupporting

confidence: 75%

Visible Light-Induced Metal Free Surface Initiated Atom Transfer Radical Polymerization of Methyl Methacrylate on SBA-15

Ma¹,

Li²,

Zhu³

et al. 2017

Preprint

View full text Add to dashboard Cite

Surface initiated atom transfer radical polymerization (SI-ATRP) is one of the most versatile technique to modify the surface properties of material. Recent developed metal free SI-ATRP makes such technique more widely applicable. Herein photo-induced metal-free SI-ATRP of methacrylates, such as methyl methacrylate, N-isopropanyl acrylamide, and N,Ndimethylaminoethyl methacrylate, on the surface of SBA-15 was reported to fabricate organicinorganic hybrid materials. SBA-15 based polymeric composite with adjustable graft ratio was obtained. The structure evolution during the SI-ATRP modification of SBA-15 was monitored and verified by FT-IR, XPS, TGA, BET, and TEM. The obtained polymeric composite showed enhanced adsorption ability for the model compound toluene in aqueous. This procedure provides a low cost, ready availability, and facile modification way to synthesize the polymeric composites without the contamination of metal.

show abstract

Section: Resultssupporting

confidence: 75%

Visible Light-Induced Metal Free Surface Initiated Atom Transfer Radical Polymerization of Methyl Methacrylate on SBA-15

Ma¹,

Li²,

Zhu³

et al. 2017

Preprint

View full text Add to dashboard Cite

show abstract

“…1À2 nm. 27 TG-DTA analysis of LP-MSN-P (Supporting Information, Figure S3) confirms the PLL attachment on the LP-MSNs. The analysis shows a mass loss of 7% (the percent weight does not include the percent weight of epoxysilane).…”

Section: Resultsmentioning

confidence: 89%

“…Consequently, the loading capacity of the particles was dramatically decreased. Differently, Kar et al 27 reported the use of a "grafting to"…”

Section: 1922mentioning

confidence: 99%

Poly-l-lysine Functionalized Large Pore Cubic Mesostructured Silica Nanoparticles as Biocompatible Carriers for Gene Delivery

et al. 2012

View full text Add to dashboard Cite

Large pore mesoporous silica nanoparticles (LP-MSNs) functionalized with poly-l-lysine (PLL) were designed as a new carrier material for gene delivery applications. The synthesized LP-MSNs are 100–200 nm in diameter and are composed of cage-like pores organized in a cubic mesostructure. The size of the cavities is about 28 nm with an entrance size of 13.4 nm. Successful grafting of PLL onto the silica surface through covalent immobilization was confirmed by X-ray photoelectron spectroscopy, solid-state 13C magic-angle spinning nuclear magnetic resonance, Fourier transformed infrared, and thermogravimetric analysis. As a result of the particle modification with PLL, a significant increase of the nanoparticle binding capacity for oligo-DNAs was observed compared to the native unmodified silica particles. Consequently, PLL-functionalized nanoparticles exhibited a strong ability to deliver oligo DNA-Cy3 (a model for siRNA) to Hela cells. Furthermore, PLL-functionalized nanoparticles were proven to be superior as gene carriers compared to amino-functionalized nanoparticles and the native nanoparticles. The system was tested to deliver functional siRNA against minibrain-related kinase and polo-like kinase 1 in osteosarcoma cancer cells. Here, the functionalized particles demonstrated great potential for efficient gene transfer into cancer cells as a decrease of the cellular viability of the osteosarcoma cancer cells was induced. Moreover, the PLL-modified silica nanoparticles also exhibit a high biocompatibility, with low cytotoxicity observed up to 100 μg/mL.

show abstract

“…The chemical shifts at 4.08 and 2.94 ppm are associated with the ethylene protons of the propargyl initiator and the ethylene protons adjacent to the pendant amino side groups, respectively. 37 From the integrated peak area ratio between these two chemical shifts, a near-theoretical chain length with monomodal distribution was estimated for the P(CbzLys) ( Table 1). In the FTIR spectrum of P(CbzLys) (Fig.…”

Section: Preparation Of the Four-arm Star Glycopolymerpolypeptide Conmentioning

confidence: 99%

Increasing bacterial affinity and cytocompatibility with four-arm star glycopolymers and antimicrobial α-polylysine

Pranantyo

Zheng

et al. 2017

Polym. Chem.

View full text Add to dashboard Cite

A series of four-arm star copolymers, incorporating glycopolymer and antimicrobial polypeptide domains, was developed in the design of forthcoming anti-infective agents. Mannose, glucose, and galactosebased glycopolymers with a variety of well-defined chain lengths were prepared via atom transfer radical polymerization, whereas linear α-polylysine was prepared via ring-opening polymerization of N-carboxyanhydride monomers. Copper-catalyzed azide-alkyne cycloaddition was employed for 'click' conjugation of the glycopolymer arms and the polypeptide chains. The glycopolymer-polypeptide conjugates were non-hemolytic and exhibited higher cytocompatibility than the linear α-polylysine. The conjugates with shorter chains of mannose-based glycopolymer arms showed an enhanced bactericidal efficacy against Gram-negative and Gram-positive bacteria, with a therapeutic selectivity half of that of the linear α-polylysine. The pendant mannose moieties of the conjugates increased microbial targeting due to their specific affinity for bacterial surfaces, and binding competition with free mannopyranoside was demonstrated. Therefore, the molecular combination of glycopolymers and polypeptides without loss of their respective activities provides an interesting concept in the design of antimicrobial agents to combat infectious disease.

show abstract

Synthesis and characterization of poly-l-lysine grafted SBA-15 using NCA polymerization and click chemistry

Cited by 28 publications

References 40 publications

Visible Light-Induced Metal Free Surface Initiated Atom Transfer Radical Polymerization of Methyl Methacrylate on SBA-15

Visible Light-Induced Metal Free Surface Initiated Atom Transfer Radical Polymerization of Methyl Methacrylate on SBA-15

Poly-l-lysine Functionalized Large Pore Cubic Mesostructured Silica Nanoparticles as Biocompatible Carriers for Gene Delivery

Increasing bacterial affinity and cytocompatibility with four-arm star glycopolymers and antimicrobial α-polylysine

Contact Info

Product

Resources

About