Synthesis and characterization of polymer encapsulated Cu–Ni magnetic nanoparticles for hyperthermia applications

Chatterjee, Jhunu; Bettge, Martin; Haik, Yousef; Chen, Ching-Jen

doi:10.1016/j.jmmm.2005.02.024

Cited by 113 publications

(82 citation statements)

References 9 publications

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“…[2]. In this regard, numerous polymer-based encapsulation techniques have been reported using different approaches to encapsulate various inorganic NPs, like silica, titania, alumina, calcium carbonate, carbon black, magnetic iron oxides, metal nanoparticles and quantum dots [3][4][5][6]. The controlled fabrication of well-defined micro-and nano-sized composites encapsulated in polymer matrices has become one of the main topics in materials science oriented towards bio-medical applications.…”

Section: Introductionmentioning

confidence: 99%

Multi-Functional Magnetic Photoluminescent Photocatalytic Polystyrene-Based Micro- and Nano-Fibers Obtained by Electrospinning

Schaer

Crittin

Kasmi

et al. 2014

Fibers

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This work reports on the implementation of electrospinning (ES) as a facile route to encapsulate nano-engineered materials in a polystyrene (PS) matrix. We applied ES to co-encapsulate two kinds of nanoparticles, i.e., upconversion nanophosphors (UCNPs) and superparamagnetic iron oxide nanoparticles (SPIONs), in polystyrene (PS)-based micro-and nano-fibers (PSFs). This approach made it possible to integrate near-infrared (NIR) light-sensitive 500-nm β-NaYF 4 :Yb, Er UCNPs with 10-nm γ-Fe 2 O 3 SPIONs in PS fibers. During the ES process, PSFs were additionally loaded with a well-established singlet oxygen ( 1 ∆ g ) photosensitizer, rose bengal (RB).The thus obtained PSFs revealed the promising features of prospective multi-functional magnetic photoluminescent photocatalytic nano-constructs. OPEN ACCESSFibers 2014, 2 76

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Section: Introductionmentioning

confidence: 99%

Multi-Functional Magnetic Photoluminescent Photocatalytic Polystyrene-Based Micro- and Nano-Fibers Obtained by Electrospinning

Schaer

Crittin

Kasmi

et al. 2014

Fibers

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“…polyvinylpyrrolidone) and microwave heating, various types of nanoparticles have been synthetized . Metals (Ni [6,7], Co [8,9], Cu [10], Pd [11], Ag [12][13][14], Pt [15][16][17], Au, [18,19] ), alloys [9,[19][20][21][22][23][24][25], oxides (MgO, TiO 2 , ZnO, SnO 2 , Gd 2 O 3 , Fe oxides and ferrites, hydroxyapatite [26][27][28][29][30][31][32][33][34][35], metal-polymer nanocomposites [36], supported metal catalysts [37][38][39][40], have been designed.…”

Section: Direct Methods For the Preparation Of Nanoparticlesmentioning

confidence: 99%

Nanoparticles of metal and metal oxides: some peculiar synthesis methods, size and shape control, application to catalysts preparation

Bozon‐Verduraz¹,

Fiévet²,

Piquemal³

et al. 2009

Braz. J. Phys.

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One step (direct) and multisteps synthesis methods of metal and oxide nanoparticles are presented including both bottom-up and top-down procedures. Chemical methods involving the polyol process allows to get either isotropic or anisotropic nanoparticles. Nanowires, nanorods and dumbells can be generated either by heterogeneous nucleation or by using a template (mesoporous silica). Top-down procedures are illustrated by laser irradiation of immersed bulk targets (Ag, Au) which generates self-organized nanostructures or colloidal solutions. Laser irradiation of these colloidal solutions modifies the size distribution and the shape of nanoparticles. Bimetallic nanoparticles are generated from mixtures of monometallic colloidal solutions. Surface-mediated methods involving a host support and an invited phase are also presented. They lead to the formation of metal or oxide clusters and nanoparticles. The speciation of these entities is correlated with the observed catalytic performances.

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“…Biocompatible MNPs coated with biodegradable polymers or molecules may generate heat when submitted to an external alternating current magnetic field, and their use is of interest because they especially target the tumoral tissue, since this is less resistant to sudden increases in temperature than the surrounding normal cells [15][16][17][18][19]. The application of hyperthermia has shown promise as a therapy against cancer [20], and it has been used to enhance the effectiveness of chemotherapy and radiotherapy [21].…”

Section: Animals and Experimental Designmentioning

confidence: 99%

“…MNPs covered with biodegradable polymers or molecules can be heated by the application of an external AC magnetic field and are therefore capable of producing localized heating in a desired area [18,19]. In this context, NPcit showed adequate biocompatibility and was effective in mediating RFHT and MHT, which produced regression in tumor aggressiveness using both types of equipment, with virtually no adverse acute effects.…”

Section: Nanoparticles (Nps) Composed Of Ferromagnetic Materials and mentioning

confidence: 99%

Comparative Efficacy of a Biocompatible Citrate-Functionalized Magnetic Fluid Mediating Radiofrequency Hyperthermia and Magnetohyperthermia to Treat Ectopic Ehrlich-Solid-Tumor-Bearing Elderly Mice

Neves¹,

Sousa²,

Vilela³

et al. 2017

J Cancer Sci Ther

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Objective: We aimed to evaluate the efficacy of a biocompatible citrate-functionalized magnetic fluid (NPCit) sample in mediating hyperthermia, using two types of alternated (AC) magnetic field equipment operating in two different ways: a portable apparatus, generating an electromagnetic field in MHz range (radiofrequency range; radiofrequency hyperthermia-RFHT) developed by our research group (CMagMHG), and a commercial one working in kHz range (magnetohyperthermia-MHT) (Magnetherm, NanoTherics Ltd, Newcastle, United Kingdom), to treat ectopic Ehrlich-solid-tumor-bearing elderly mice. Methods:Females intraperitoneally anesthetized with ketamine (80 mg/kg) and xylazine (10 mg/Kg) were subcutaneously inoculated with Ehrlich ascitic tumor cell suspension (1.03 × 10 6 viable cells) in the upper head region for solid form implantation. After 48 hours, mice received one of four treatments: (a) filtered water and no tumor implantation (negative control); (b) tumor inoculation and no treatment (tumor control); (c) intratumoral injection of NPCit (40 µL) containing 18 × 10 18 particles/mL and 13 minutes' exposure to CMagMHG, operating at 1MHz, 40 Oe field amplitude; (d) intratumoral injection of NPCit and 13 minutes' exposure to Magnetherm, assembled with 17-turn coil, capacitive box B22, operating under 330 kHz, 4.9 A, 25 V and maximum field strength 170 Oe. Treatments occurred once daily for three consecutive days. Tumor histopathology and semi-quantitative analysis of necrosis area served to assess tumor aggressiveness and regression. Possible acute side effects were assessed by animals' body and spleen weight and hemogram.Results: NPcit showed adequate biocompatibility and was effective in mediating RFHT and MHT, which promoted significant increases in necrosis area using both equipment types. Conclusion:Our findings evidence the potential use of NPcit mediating hyperthermia for future use as an adjuvant in breast cancer therapy.

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Synthesis and characterization of polymer encapsulated Cu–Ni magnetic nanoparticles for hyperthermia applications

Cited by 113 publications

References 9 publications

Multi-Functional Magnetic Photoluminescent Photocatalytic Polystyrene-Based Micro- and Nano-Fibers Obtained by Electrospinning

Multi-Functional Magnetic Photoluminescent Photocatalytic Polystyrene-Based Micro- and Nano-Fibers Obtained by Electrospinning

Nanoparticles of metal and metal oxides: some peculiar synthesis methods, size and shape control, application to catalysts preparation

Comparative Efficacy of a Biocompatible Citrate-Functionalized Magnetic Fluid Mediating Radiofrequency Hyperthermia and Magnetohyperthermia to Treat Ectopic Ehrlich-Solid-Tumor-Bearing Elderly Mice

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