Synthesis and characterization of quantum dots designed for biomedical use

Kuzyniak, Weronika; Adegoke, Oluwasesan; Sekhosana, Kutloano Edward; D’Souza, Sarah; Tshangana, Sesethu Charmaine; Hoffmann, B.; Ermilov, Eugeny; Nyokong, Tebello; Höpfner, Michael

doi:10.1016/j.ijpharm.2014.03.037

Cited by 37 publications

(19 citation statements)

References 35 publications

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“…QDs are a kind of tiny inorganic semiconductor nanocrystals with a diameter of 1–10 nm. Due to its unique surface chemistry available for modification and multi-wavelength luminescence characteristics of high luminous stability, they have attracted much attention in tumor research and become an ideal material for targeted drug delivery [ 65 ]. The general structure of QDs is composed of a semiconductor core, coated with a shell to change its physical and chemical properties and improve solubility [ 66 ].…”

Section: Development Of Nano-sized Delivery Systems For Solid Cancmentioning

confidence: 99%

Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies

Wei

Lau

2020

Cancers

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Conventional chemotherapy is still an important option of cancer treatment, but it has poor cell selectivity, severe side effects, and drug resistance. Utilizing nanoparticles (NPs) to improve the therapeutic effect of chemotherapeutic drugs has been highlighted in recent years. Nanotechnology dramatically changed the face of oncology by high loading capacity, less toxicity, targeted delivery of drugs, increased uptake to target sites, and optimized pharmacokinetic patterns of traditional drugs. At present, research is being envisaged in the field of novel nano-pharmaceutical design, such as liposome, polymer NPs, bio-NPs, and inorganic NPs, so as to make chemotherapy effective and long-lasting. Till now, a number of studies have been conducted using a wide range of nanocarriers for the treatment of solid tumors including lung, breast, pancreas, brain, and liver. To provide a reference for the further application of chemodrug-loaded nanoformulations, this review gives an overview of the recent development of nanocarriers, and the updated status of their use in the treatment of several solid tumors.

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Section: Development Of Nano-sized Delivery Systems For Solid Cancmentioning

confidence: 99%

Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies

Wei

Lau

2020

Cancers

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“…Two models making use of fertilized hen's eggs have been established as the main tools in toxicological research: the chicken development model and the CAM assay (Figure 1) 56,[66][67][68][69][70][71][72][73][74][75]. The chicken development model evaluates toxicological effects of specific substances on embryogenesis without further manipulation of the egg [66][67][68][69][70][71][72][73][74][75].…”

Section: The Evaluation Of Nanotoxicity With Fertilized Hen's Eggsmentioning

confidence: 99%

The Chorioallantoic Membrane Assay in Nanotoxicological Research—An Alternative for In Vivo Experimentation

et al. 2020

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Nanomaterials unveil many applicational possibilities for technical and medical purposes, which range from imaging techniques to the use as drug carriers. Prior to any human application, analysis of undesired effects and characterization of their toxicological profile is mandatory. To address this topic, animal models, and rodent models in particular, are most frequently used. However, as the reproducibility and transferability to the human organism of animal experimental data is increasingly questioned and the awareness of animal welfare in society increases at the same time, methodological alternatives are urgently required. The chorioallantoic membrane (CAM) assay is an increasingly popular in ovo experimental organism suitable for replacement of rodent experimentation. In this review, we outline several application fields for the CAM assay in the field of nanotoxicology. Furthermore, analytical methods applicable with this model were evaluated in detail. We further discuss ethical, financial, and bureaucratic aspects and benchmark the assay with other established in vivo models such as rodents.

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“…The luminescent properties, combined with low or absent cytoxicity [158,299], (except for cadmium chalcogenides, broadly used as luminescent quantum dot [20,258,[303][304][305][306][307][308][309][310][311]), make transition metal sulphide appealing candidate probes for optical bioimaging applications and further related bio-applications (e.g., photothermal and/or photodynamic applications [10,312,313]). As we shall extensively discuss in the next section, all these applications require a chemical, photochemical and thermal stable functionalisation.…”

Section: Applications-oriented Functionalisation Of Transition Metal mentioning

confidence: 99%

“…Commonly used organic fluorophores have two significant limitations: (1) they cannot fluoresce continuously over long periods (long term imaging) and (2) they are not optimised for multicolour applications (multiplexing) [372], i.e., simultaneous, not sequential, detection of multiple signals. The unique optical properties of inorganic colloids, in many case referred to as Quantum Dots (QD) [20,39,44,46,163,210,307,311,[373][374][375][376][377], make them instead appealing as in vivo and in vitro fluorophores in a variety of biological investigations because they are able to overcome problems of long-term stability and multi-signal detection [105,372,378]. Nevertheless, one of the most significant drawbacks is the toxicity of QDs.…”

Section: Figurementioning

confidence: 99%

Functionalisation of Colloidal Transition Metal Sulphides Nanocrystals: A Fascinating and Challenging Playground for the Chemist

2017

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Abstract:Metal sulphides, and in particular transition metal sulphide colloids, are a broad, versatile and exciting class of inorganic compounds which deserve growing interest and attention ascribable to the functional properties that many of them display. With respect to their oxide homologues, however, they are characterised by noticeably different chemical, structural and hence functional features. Their potential applications span several fields, and in many of the foreseen applications (e.g., in bioimaging and related fields), the achievement of stable colloidal suspensions of metal sulphides is highly desirable or either an unavoidable requirement to be met. To this aim, robust functionalisation strategies should be devised, which however are, with respect to metal or metal oxides colloids, much more challenging. This has to be ascribed, inter alia, also to the still limited knowledge of the sulphides surface chemistry, particularly when comparing it to the better established, though multifaceted, oxide surface chemistry. A ground-breaking endeavour in this field is hence the detailed understanding of the nature of the complex surface chemistry of transition metal sulphides, which ideally requires an integrated experimental and modelling approach. In this review, an overview of the state-of-the-art on the existing examples of functionalisation of transition metal sulphides is provided, also by focusing on selected case studies, exemplifying the manifold nature of this class of binary inorganic compounds.

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Synthesis and characterization of quantum dots designed for biomedical use

Cited by 37 publications

References 35 publications

Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies

Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies

The Chorioallantoic Membrane Assay in Nanotoxicological Research—An Alternative for In Vivo Experimentation

Functionalisation of Colloidal Transition Metal Sulphides Nanocrystals: A Fascinating and Challenging Playground for the Chemist

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