Synthesis and characterization of some novel fatty acid analogues: A preliminary investigation on their activity against human lung carcinoma cell line

Selvaraj, Jubie; Palanisamy, Dhanabal; Azam, Mohammed Afzal; Muruganantham, N.; Rajagopal, Kalirajan; Elango, K

doi:10.1186/1476-511x-12-45

Cited by 13 publications

(4 citation statements)

References 13 publications

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“…The compounds show the strongest antitumour activity [22]. Earlier, the author of the present chapter has reported some novel fatty acid heterocyclic conjugates and their anticancer evaluation on human lung carcinoma cell lines [23,24]. The compounds have shown comparable cytotoxicity towards human lung carcinoma cell lines.…”

Section: Fatty Acid Analogues As Anticancer Agentsmentioning

confidence: 77%

Fatty Acids and Their Analogues as Anticancer Agents

Selvaraj¹

2017

Fatty Acids

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Recent research supports the beneficial effects of dietary polyunsaturated fatty acids (PUFAs) on inhibiting tumour development. Long-chain fatty acids modulate the tumour cell response to chemotherapeutic drugs. Investigators recently claimed high dietary intake of omega-6 polyunsaturated fatty acids such as linoleic acid especially in association with a low intake of omega-3 polyunsaturated fatty acids such as docosahexaenoic acid to increase risks for cancers of the breast, colon and possibly prostate. In addition to these facts, a number of investigations have demonstrated that a modified fatty acid analogues are promising molecules in cancer prevention and have potential in the treatment of cancer. Although billions of dollars have been spent on research and development on anticancer drugs, the disease remains uncontrolled. It is expected that anticancer agents preferentially kill tumour cells without causing adverse effects on normal cells. But this is rarely achieved with the existing cancer therapy. Hence, polyunsaturated fatty acids have come under the category of nutraceuticals/functional foods; their exploration in the treatment of cancer may be considered as safe. This chapter describes the effects of long-chain fatty acids and their analogues in cancer chemotherapy.

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Section: Fatty Acid Analogues As Anticancer Agentsmentioning

confidence: 77%

Fatty Acids and Their Analogues as Anticancer Agents

Selvaraj¹

2017

Fatty Acids

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“…Chemistry Earlier we reported (Jubie et al, 2013) antitumor activity of fatty acid analogues SA-1, SA-2, GLA-1 and GLA-2 against human lung carcinoma cell lines. In the present investigation, fatty acid analogues SA-7, PA-1, PA-2, PA-4, PA-5, LA-1 and LA-2 were also synthesised as per our reported methods (Jubie et al, 2013(Jubie et al, , 2012b.…”

Section: Resultsmentioning

confidence: 99%

“…In the present investigation, fatty acid analogues SA-7, PA-1, PA-2, PA-4, PA-5, LA-1 and LA-2 were also synthesised as per our reported methods (Jubie et al, 2013(Jubie et al, , 2012b. Analogues SA-3 and PA-3 were synthesised by the cyclo condensation of triazole substituted analogues PA-2 and SA-2 with SA-1, SA-7,PA-1,PA-4,PA-5, LA-1,GLA-1 SA-2, PA-2, GLA-2.LA-2 SA-3, PA-3…”

Section: Resultsmentioning

confidence: 99%

Design, synthesis and antidepressant activities of some novel fatty acid analogues

et al. 2014

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The present study deals with the optimization of some novel heterocyclic compounds containing two biological scaffolds such as long alkyl/alkenyl side chain of fatty acids and five-membered azoles named as 1,3,4-oxadiazole, 1,2,4-triazole and 1,3,4-thiadiazoles as antidepressant agents. In-silico docking studies have been carried out for the tested compounds into the crystal structure of human mono amine oxidase-B using GLIDE integrated Maestro (9.3) version. Five analogues exhibited higher XP G-Scores than selegeline. Also, it was verified by in vivo antidepressant screening, where two of the compounds PA-2 and GLA-2 showed significant antidepressant activity. Drug likelinesss and comparative bioactive analysis for the analogues are done using Qik.Prop 3.4.

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“…Many commercial methods are available for producing gamma linolenic acid (GLA) concentrates include winterization, fractional distillation, urea-inclusion, high performance liquid chromatography and argentated silica gel chromatography [ 4 – 7 ]. Even though GLA concentrates mentioned above are sufficient for most applications; however pharmaceutical applications of GLA require higher concentrations of GLA, often in excess of 90 % but many of these methods did not produce the satisfied output [ 8 ]. Hence new method for producing higher concentrations of gamma linolenic acid and its ester forms from Spirulina platensis are urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Isolation of methyl gamma linolenate from spirulina platensis using flash chromatography and its apoptosis inducing effect

Selvaraj¹,

Dhanabal²,

Chaitanya³

2015

BMC Complement Altern Med

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BackgroundIsolation of methyl gamma linolenate from Spirulina platensis using flash chromatography and its apoptosis inducing effect against human lung carcinoma A- 549 cell lines.MethodsGamma linolenic acid is an important omega-6 polyunsaturated fatty acid (PUFA) of medicinal interest was isolated from microalgae Spirulina platensis using flash chromatography system (Isolera system) as its methyl ester. The isolated methyl gamma linolenate was characterized by IR, 1H NMR, 13C NMR and mass spectral analysis and the data were consistent with the structure.ResultsThe percentage yield of isolated methyl gamma linolenate is found to be 71 % w/w, which is a very good yield in comparison to other conventional methods. It was subjected to in-vitro cytotoxic screening on A-549 lung cancer cell lines using SRB assay and result was compared with standard rutin.ConclusionIt may be concluded that the Flash chromatography system plays a major role in improving the yield for theisolation of methyl gamma linoleate from Spirulina platensis and the isolated molecule is a potent cytotoxicagent towards human lung carcinoma cell lines, however it may be further taken up for an extensive study.

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Synthesis and characterization of some novel fatty acid analogues: A preliminary investigation on their activity against human lung carcinoma cell line

Cited by 13 publications

References 13 publications

Fatty Acids and Their Analogues as Anticancer Agents

Fatty Acids and Their Analogues as Anticancer Agents

Design, synthesis and antidepressant activities of some novel fatty acid analogues

Isolation of methyl gamma linolenate from spirulina platensis using flash chromatography and its apoptosis inducing effect

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