Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity

Pahontu, Elena Mihaela; Fala, Valeriu; Gulea, Aurélian; Poirier, Donald; Țapcov, Victor; Roșu, Tudor

doi:10.3390/molecules18088812

Cited by 83 publications

(70 citation statements)

References 46 publications

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“…In many cases not only free ligands, but also their metal complexes possess biological activity: picolinylidene TSC derivatives or their metal complexes have been reported to possess antimalarial [68], modest antibacterial [86], modest (to no) antifungal [87,88], but promising antitumor activity [88][89][90]. Salicylidene TSCs form redox-active complexes with various metal ions, including Ru(II) [91,92] and Cu(II) [93][94][95]. The free ligands and their Ni(II) [96], Cu(II), Ru(II) and Zn(II) [92,94,95] complexes were reported to possess antibacterial and antifungal activity.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

“…Salicylidene TSCs form redox-active complexes with various metal ions, including Ru(II) [91,92] and Cu(II) [93][94][95]. The free ligands and their Ni(II) [96], Cu(II), Ru(II) and Zn(II) [92,94,95] complexes were reported to possess antibacterial and antifungal activity. N4-phenylsalicylidene TSC (3a) has also been reported to show antitumor activity [95,97], GABA A receptor inhibition [98] and a very weak inhibition of RR [99].…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

“…The free ligands and their Ni(II) [96], Cu(II), Ru(II) and Zn(II) [92,94,95] complexes were reported to possess antibacterial and antifungal activity. N4-phenylsalicylidene TSC (3a) has also been reported to show antitumor activity [95,97], GABA A receptor inhibition [98] and a very weak inhibition of RR [99]. Similarly, the acetaniline TSC (2p) forms Cu(II) complexes with moderate antibacterial and antifungal activity [46].…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

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Design, synthesis and biological evaluation of thiosemicarbazones, hydrazinobenzothiazoles and arylhydrazones as anticancer agents with a potential to overcome multidrug resistance

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Tóth

Füredi

et al. 2016

European Journal of Medicinal Chemistry

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Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

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Design, synthesis and biological evaluation of thiosemicarbazones, hydrazinobenzothiazoles and arylhydrazones as anticancer agents with a potential to overcome multidrug resistance

Pape

Tóth

Füredi

et al. 2016

European Journal of Medicinal Chemistry

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Section: +mentioning

confidence: 99%

“…[16][17][18][19][20] The increased antimicrobial activity is likely related to azole's better solubility, bioavailability and interaction with DNA (deoxyribonucleic acid) through intermolecular associations. 19,20 Increased lipophilicity in the complexes reduces the permeability barrier of cells and slows normal cellular processes in microorganisms, resulting in increased antimicrobial activity. [19][20][21][22][23] With the aim of developing new antifungal and antibacterial compounds, we report the synthesis, characterization, and antibacterial and antifungal activities of metal complex derivatives of azoles.…”

Section: +mentioning

confidence: 99%

Metal Complex Derivatives of Azole: a Study on Their Synthesis, Characterization, and Antibacterial and Antifungal Activities

Castillo¹,

Bello-Vieda²,

Nuñez‐Dallos³

et al. 2016

Journal of the Brazilian Chemical Society

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Four new zinc complex derivatives of azoles and ligands were synthesized and isolated as white air-stable solids and characterized by elemental analyses, thermogravimetric analysis (TGA), infrared spectroscopy, nuclear magnetic resonance (NMR) and mass spectra. The elemental analysis, theoretical calculations and NMR show that the complexes likely have a 1:1 (M:L) stoichiometry and tetrahedral geometry. To evaluate the biological activity of the complexes and to discuss the role of metal ions and structural properties, the ligands and their metal complexes have been studied. Their antimicrobial activity was determined in vitro by agar-well diffusion and broth microdilution against nine bacterial strains and seven fungal strains with clinical relevance. In vitro assays showed that the complexes exhibited moderate antibacterial and/or antifungal activities. The antimicrobial activity was found to be more active for the metal complexes than the ligands. The metal complexes that contained copper and cobalt, respectively, displayed notable antibacterial and antifungal effects against all the tested bacterial strains. The minimum inhibitory concentration 50 (MIC 50 ) values were in the range 2454-0.7 μg mL -1 . Metal complexes were more effective at inhibiting bacteria than fungi. The results could provide a high-potential solution for antimicrobial growth resistance, for both bacteria and fungi.

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Synthesis, characterization, crystal structure of novel Cu (II), Co (III), Fe (III) and Cr (III) complexes with 2‐hydroxybenzaldehyde‐4‐allyl‐S‐methylisothiosemicarbazone: Antimicrobial, antioxidant and in vitro antiproliferative activity

Pahontu

Usataia

Graur

et al. 2018

Applied Organom Chemis

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2-Hydroxybenzaldehyde-4-allyl-S-methylisothiosemicarbazone and Cu (II), Co (III), Fe (III) and Cr (III) complexes were synthesized and characterized. The new obtained compounds were investigated by elemental analysis, magnetic susceptibility measurements, molar electric conductivity, IR, 1 H NMR, 13 C NMR, UV-Vis spectroscopy. In addition, the structure of the ligand and six complexes has been determined by single-crystal X-ray diffraction analysis.The Cu atom in complex 3 is penta-coordinated in a distorted square-pyramidal coordination geometry, while the metals in complexes 5-9 are in a distorted octahedral environment. For all compounds the antimicrobial activity was studied on a series of standard strains, such as Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, Salmonella abony and Candida albicans.The in vitro antiproliferative activity of the ligand and complexes was screened on human leukemia HL-60 cells, human cervical epithelial HeLa cells, human epithelial pancreatic adenocarcinoma BxPC-3 cells, human muscle rhabdomyosarcoma spindle and large multinucleated RD cells. The primary screening on a wider series of cancer cells showed that copper coordination compound 2 manifests high activity towards HeLa, BxPC-3 and RD cancer cells, which is three-six times higher than the activity of doxorubicin. The selectivity index that is the ratio between the IC 50 value for the normal MDCK cells and IC 50 values for the cancer cells varies in the range 2.44-21.17. This index is 5.5-11 times higher for the copper coordination compound 2 than for the doxorubicin. Cr (III), Fe (III) and Co (III) coordination compounds 6-9 manifest high antioxidant activity towards ABTS •+ that exceeds 47-67 times the activity of Trolox. ---This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity

Cited by 83 publications

References 46 publications

Design, synthesis and biological evaluation of thiosemicarbazones, hydrazinobenzothiazoles and arylhydrazones as anticancer agents with a potential to overcome multidrug resistance

Design, synthesis and biological evaluation of thiosemicarbazones, hydrazinobenzothiazoles and arylhydrazones as anticancer agents with a potential to overcome multidrug resistance

Metal Complex Derivatives of Azole: a Study on Their Synthesis, Characterization, and Antibacterial and Antifungal Activities

Synthesis, characterization, crystal structure of novel Cu (II), Co (III), Fe (III) and Cr (III) complexes with 2‐hydroxybenzaldehyde‐4‐allyl‐S‐methylisothiosemicarbazone: Antimicrobial, antioxidant and in vitro antiproliferative activity

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