Synthesis and Characterization of Zirconium Dioxide Anchored Carbon Nanofiber Composite for Enhanced Electrochemical Determination of Chloramphenicol in Food Samples

Abstract

We developed the zirconium dioxide anchored carbon nanofiber (ZrO 2 /CNF) composite modified glassy carbon electrode (GCE) for the enhanced and selective electrochemical determination of chloramphenicol (CPL). The as-prepared composite was characterized by different analytical and spectroscopic techniques. The voltammetry techniques were used to evaluate the electrochemical activity of ZrO 2 /CNF composite. Its electrochemical behavior and the roles of ZrO 2 and CNF in the composite toward electrochemical reduction of CPL were elucidated and demonstrated using voltammetry techniques. The ZrO 2 /CNF modified GCE displayed the enhanced electrocatalytic behavior and reduction peak current response toward for the detection of CPL than that of other modified electrodes. The detailed electrochemical reasons on such excellent performance were also discussed. Differential pulse voltammetry (DPV) is a suitable electrochemical technique to measure CPL reduction, which determined the CPL in the linear range from 0.005 to 903.76 μM and with the lowest detection limit (LOD) of 0.0018 μM. The ZrO 2 /CNF modified GCE shows its excellent selectivity toward CPL in the presence of antibiotics and sulfa drug. Also, the viability of the raised method has been preliminarily examined by the analysis of CPL in real spiked samples. All these features indicate that the ZrO 2 /CNF composite is a promising candidate as a new class of electrocatalyst in the development of highly selective CPL electrochemical sensor.

Two-Dimensional Copper Tungstate Nanosheets: Application toward the Electrochemical Detection of Mesalazine

“…Likewise, the significant merits are involved in using MSA such as inhibiting bacterial peptides and inhibits cell injury in the inflamed mucosa by trapping the reactive oxygen species, thereby, greatly reducing their toxicity. − However, MSA is an aminosalicylate drug that acts locally in the gut and has its major actions, which can cause several health problems. , Therefore, accurate determination of MSA in clinical and pharmacological aspects is a very important task. In recent years, several analytical techniques have been investigated and developed including high-performance liquid chromatography, UV spectrophotometry, colorimetry, fluorescence sensors, electrochemical sensors, capillary electrophoresis, and mass spectrometry. − Among these, electrochemical methods could provide low cost, facile operation, rapid response, and good selectivity and sensitivity. − Detection of MSA in a bare GC electrode is not possible due to the high detection limit, low sensitivity, and small linear range. Therefore, invention of highly sensitive electrodes for the detection of MSA in biological fluids and pharmaceutical samples is quit crucial.…”

A review on nanomaterial-based electrodes for the electrochemical detection of chloramphenicol and furazolidone antibiotics

“…The developed electrode precisely detects the CP in real specimens. Further, an electrochemical sensor developed by Kokulnathan et al 2018, 115 using a zirconium dioxide(ZrO 2 )-embedded carbon nanofiber (CNF) composite altered with GCE (glassy carbon electrode). The ZrO 2 /CNF/GCE-modified electrode determined the CP with a lower limit of detection in the linear concentration range of 0.005–903.76 μM using the DPV transduction method.…”

Development of an Electrochemical Platform Based on Nanoplate-like Zirconium Phosphate for the Detection of Furazolidone

“…Determination of FZD can be performed using classic analytical procedures such as chemiluminescence, liquid chromatography–tandem mass spectrometry, microemulsion electrokinetic chromatography, electrochemical sensing, and enzyme-linked immunosorbent assay. − Electrochemical sensing as a measuring tool is of significant interest due to its several advantages, including specificity, mass production, eco-friendly nature, portability, fast response, cost-effectiveness, and good sensitivity. − Previously, several electrocatalyst reports were presented for FZD detection that utilize metal nanoparticles, carbonous materials, and so on. ,, The major drawbacks of traditional material are poor selectivity and overlapping, which severely limit the application of electrochemical sensors. Continuing effort is still being made to search for better electrocatalysts to satisfy the global needs of antifouling properties and enhanced FZD detection.…”