Synthesis and Characterization of ZnO Nanoparticles via Thermal Decomposition for Zn(II) Schiff Base Complex

Subhi, Hadeer Mohammed; Bader, Ali T.; Al-Gubury, Hazim Y.

doi:10.22146/ijc.74753

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…1 H-NMR spectra were determined in deuterated dimethylsulphoxide (DMSO-d6); the chemical shifts were reported in δ (ppm). The NMR ultra-shield spectrophotometer, 500 MHz, was conducted at Tehran University (Subhi et al 2022). The solvents and chemicals used were all obtained from commercial suppliers and were of analytical quality.…”

Section: Methodology Generalmentioning

confidence: 99%

Synthesis and biological activity evaluation of new isatin-gallate hybrids as antioxidant and anticancer agents (in vitro) and in silico study as anticancer agents and coronavirus inhibitors

Al-Mudhafar,

Wadi

2024

PHAR

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Background: The hybrid compounds hold promise for developing novel pharmaceuticals, potentially exhibiting greater activity, mainly against viruses and cancer diseases, than their components. Objective: In this study, researchers explored the potential synergistic effects of hybrid molecules by designing and synthesizing a series of isatin-gallate hybrids, denoted as N’-(5-substituted-2-oxoindolin-3-ylidene)-3,4,5-trihydroxybenzohydrazide (3a–d). Methods: Isatin-gallate hybrids (3a–d) were synthesized by reacting gallic hydrazide with each of the isatin analogs (2a–d). The structures of all produced compounds were described using spectrum methods such as fourier transform infrared (FTIR), 1H-nuclear magnetic resonance spectroscopy (1H-NMR), and physicochemical attributes. The evaluation of the tested hybrids (3a–d) involved assessing their in vitro antioxidant activities using the α, α-diphenyl-β-picrylhydrazyl (DPPH) free radical scavenging method and cytotoxic activities through the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] colorimetric assay for measuring cellular growth. Furthermore, in silico analysis was applied to the final hybrids to evaluate their effects as anticancer and anti-coronavirus agents. Conclusion: Among the examined hybrid compounds, 3b demonstrated substantial in vitro antioxidant and cytotoxic activities. In silico analysis revealed slight variations in the anticancer activity of compounds 3a–d, with differing affinities observed across various cancer cell lines. Additionally, these compounds exhibited moderate efficacy in inhibiting coronavirus activity.

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Section: Methodology Generalmentioning

confidence: 99%

Synthesis and biological activity evaluation of new isatin-gallate hybrids as antioxidant and anticancer agents (in vitro) and in silico study as anticancer agents and coronavirus inhibitors

Al-Mudhafar,

Wadi

2024

PHAR

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Section: Methodology Generalmentioning

confidence: 99%

Figure 6 from: Al-Mudhafar MMJ, Wadi JS (2024) Synthesis and biological activity evaluation of new isatin-gallate hybrids as antioxidant and anticancer agents (in vitro) and in silico study as anticancer agents and coronavirus inhibitors. Pharmacia 71: 1-11. https://doi.org/10.3897/pharmacia.71.e124992

Al-Mudhafar,

Wadi

2024

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Synthesis, Evaluation of anticancer and antimicrobial activities of some Schiff bases derivatives

Farhan,

Ibrahim,

Ali

2023

Al-Kitab J. Pure Sci.

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In this research, compound [1,2-Bis-(4-amino-5-mercapto-4H-[1,2,4]triazol-3-yl)-ethane-1,2-diol] was used as starting material for synthesis different Schiff's Bases compounds. The fusion of tartaric acid with thiocarbohydrazide produce the compound (C1), the Schiff's bases (C2-C4) were created through the condensation of substances (C1) with different substituted benzaldehydes in presence of glacial acetic acid as catalyst. Thin layer chromatography (TLC) was used to confirm the compounds' purity, and spectroscopic methods were used to infer the compounds' structures (FTIR) and magnetic nuclear resonance spectroscopy (1H-NMR and 13C-NMR). The agar well diffusion method was used to test synthesized compounds for their antibacterial activity against K. pneumonia and S. aureus, and the findings were inconsistent. Target substances were tested for their ability to kill human breast cancer at concentrations of 50 and 100 g/mL. Human muscle tissue HC normal cell line, human cervical cancer Hela cell line, and HePG2 cell line. The results showed that the chemicals had potential cytotoxic activity against the Hela cell line, particularly compound (C4), which had the greatest inhibition at doses of 100 mg/mL among the examined substances

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Synthesis and Characterization of ZnO Nanoparticles via Thermal Decomposition for Zn(II) Schiff Base Complex

Cited by 4 publications

References 30 publications

Synthesis and biological activity evaluation of new isatin-gallate hybrids as antioxidant and anticancer agents (in vitro) and in silico study as anticancer agents and coronavirus inhibitors

Synthesis and biological activity evaluation of new isatin-gallate hybrids as antioxidant and anticancer agents (in vitro) and in silico study as anticancer agents and coronavirus inhibitors

Synthesis, Evaluation of anticancer and antimicrobial activities of some Schiff bases derivatives

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