Cobalt(II), nickel(II), and copper(II) complexes containing bidentate ligands )5-(4-nitrophenyl)-4-((4-phenoxybenzylidene)amino)-4H-1,2,4-triazole-3-thiol) could be synthesized by the condensation reaction between 1,2,4-triazole derivative and p-phenoxy benzaldehyde. The ligand and its complexes were characterized by various spectroscopic techniques such as FTIR, UV-visible, 1H and 13C-NMR, element analysis, molar conductance, and magnetic susceptibility test. The new ligand was exploited as a ligand to coordinate with Co(II), Ni(II), and Cu(II) by a molar ratio of 1:2 (metal:ligand). The prepared complexes (C1, C2, and C3) were exposed to thermo-gravimetric analysis (TGA/DTG) under an inert atmosphere to investigate their thermal stability. The ligand (L) degradation was also investigated as a reference. The results indicated that the complexes proposed structures had an octahedral geometry.

A new Schiff base ligand(HL) was synthesized by condensation of 4-amino-5-(4-nitrophenyl)-4H-1,2,4-triazole-3-thiol with 4-phenoxybenzaldehyde. A new three metal complexes Zn (II), Cd (II) and Hg (II) with Schiff ligand (HL) ware synthesized by molar ratio of ligand : metal as 2:1. The ligand and metal complexes were characterization by H1-NMR, FT-IR, Atomic absorption, CHNS analysis, molar conductivity magnetic susceptibility and melting point. There are study thermal analysis TGA-DTG for the ligand and metal complexes. All complexes were found to be non-electrolyte. The biological activity (antibacterial) in-vitro are investigated for the complexes at prepared concentration (1*10-3 M) and showed inhibition ability against growth of the four types of pathogenic bacteria: [Staphylococcus aurous. and Streptococcus sp.] as gram positive and [Escherichia coli and Pseudomonas aeruginosa] as gram negative. The most of these complexes are effective against both types of bacteria in varying degree, with high activity for Hg (II) complexes.

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Bioconjugates represent a novel class of therapeutics that offer promise in the treatment of cancer. These compounds are formed by combining a targeting molecule, such as an antibody or peptide, with a therapeutic agent, such as a chemotherapy drug or toxin. This approach allows for targeted delivery of the therapeutic agent to cancer cells, minimizing damage to healthy tissues and reducing side effects. Bioconjugates have shown significant potential in preclinical and clinical studies, with several FDA-approved drugs currently available for the treatment of cancer. There are several types of bioconjugates currently being developed for cancer treatment, including antibody-drug conjugates (ADCs), peptide-drug conjugates (PDCs), and nanoparticle-drug conjugates (NDCs). ADCs are the most well-established type of bioconjugate and have been approved for the treatment of several types of cancer, including breast cancer, lymphoma, and leukemia. PDCs and NDCs are newer classes of bioconjugates that are still in the preclinical and early clinical stages of development. Ongoing research in this field aims to improve the efficacy and safety of bioconjugates and expand their use to a wider range of cancer types. As research in this field continues to advance, we can expect to see even more innovative and effective bioconjugate drugs being developed in the future. These drugs are designed to target specific cancer cells, while leaving healthy cells unharmed, and have the potential to revolutionize cancer treatment. Furthermore, bioconjugates can be tailored to individual patients, allowing for personalized and targeted cancer therapy.

Global water pollution caused via dye and pollutants have been reported to need touched an alarming level. These hazardous pollutants pose important threats to ecosystem , humans , due to their carcinogenicity, mutagenicity and toxicity. Different method needed to removal of dyes from waste water, like chemical oxidation, extraction, physical adsorption, electrochemical treatments and zonation. Though, these methods conventional are constrained via little efficiency great cost ,stability, and harmful formation through-produces. Wastewater from production dyestuff is one of the main pollutants water. Different ways have been useful for the remediation of water contaminated. In the present study, the utilize of low-cost, abundantly available, greatly efficient and simply obtained ecofriendly adsorbents like clay and activated carbons have been reported as an alternative to the current expensive ways of dye removal from aqueous solution. .About of the methods depend of the several will yield from (AC). kind of AC is useful: (1) it acts as a dye adsorbent, not only in straight forward methods of the adsorption but too in AC-improved clotting and filtration membrane methods; (2) it strong produces of the oxidizing agents (typically, radicals (_OH)) in electro chemical oxidation dye; (3)it catalysis _OH production in (AOPs); (This reviews kind of clay and AC in dye de-colorization, assesses the possibility of each AC-altered de colorization method and discusses perspectives on future research.