Synthesis, characterization of new 5-(4-nitrophenyl)-4-((4 phenoxybenzylidene)amino)-4H-1,2,4-triazole-3-thiol metal complexes and study of the antibacterial activity

A significant issue in cancer biology is finding anticancer therapies that effectively kill cancer cells. Through the use of several aldehydes, Schiff bases based on branched poly (p‐hydroxy styrene) are created. The branched polymer is first chloroacetylated, then aminated with 1,4‐phenylenediamine, and finally, aldehydes are reacted with the aminated polymer to produce the Schiff base compounds. Through the utilization of FTIR, TGA, XRD, NMR, and elemental analysis, all synthesized Schiff‐bases are identified and characterized. Further, the antineoplastic potential of all Schiff bases is evaluated against different cancer cell lines. The results gained from this study indicate that the Schiff base polymers have cytotoxic power against cancer cells depending on cancer cell type and this antiproliferation potency is dose‐concentration dependent. Importantly, the prepared S1 Schiff‐base polymer shows potent cytotoxicity and is able to trigger the apoptosis and reactive oxygen species (ROS) in MCF‐7 cells. Further, it downregulates VEGFR protein expression. The Schiff base polymers would have extensive applications in the biological disciplines.

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“…The maximum DTG was about 440°C and the residual weight was 1%, 24%, 35.8%, and 15.5% for S1, S2, S3, and S4. [ 44,45 ]…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization, and Anticancer Potency of Branched Poly (p‐Hydroxy Styrene) Schiff‐Bases

Kenawy

El-Khalafy

Abosharaf

et al. 2023

Macromolecular Bioscience

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“…The precipitate was washed with 100 mL of anhydrous ether and subsequently vacuum-dried. The obtained potassium salt was in quantitative yield and was not subjected to further purification as it was utilized in the subsequent step [12].…”

Section: Synthesis Of Potassium Salt Of Hydrazide Compound (3)mentioning

confidence: 99%

Synthesis and Characterization of a Novel Azo-Dye Schiff Base and Its Metal Ion Complexes Based on 1,2,4-Triazole Derivatives

Ahmed Rasheed Al-qasii,

Bader,

Mosaa

2023

Indones. J. Chem.

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The study focused on producing and examining the properties of the 2-(((3-mercapto-5-(4-nitrophenyl)-4H-1,2,4-triazol-4-yl)imino)methyl)-4-(((4-mercaptophenyl) diazenyl)phenol) ligand (L) and its complexes with three transition metal ions, namely Ni(II), Co(II), and Cu(II). The ligand was formed through diazotization and coupling reactions between 4-aminobenzenethiol and a coupling Schiff base derived from 1,2,4-triazole. The characterization of the ligand and its metal ion complexes was carried out using analytical techniques such as FTIR, 1H- and 13C-NMR, UV-visible spectroscopy, and thermal analysis (TGA and DTG). Various physical methods were employed to synthesize and analyze the properties of the three mononuclear Co(II), Ni(II), and Cu(II) complexes with the azo-dye Schiff's base ligand. Based on the microanalysis and spectroscopic results, it was determined that the coordination between the azo Schiff base ligand and the central metal ion occurred through the NOS-donating atoms of the ligand. The analysis of the electronic spectra revealed that the synthesized Co(II) and Ni(II) complexes exhibited an octahedral geometry, while the Cu(II) complex had a distorted octahedral geometry. The implications of the finding regarding the octahedral and distorted-octahedral geometries include expanding the structural diversity in coordination chemistry, providing insights into ligand-metal interactions, and understanding the influence of geometry on properties.

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“…The synthesis used a reported procedure in the literatures [8][9]. Potassium 2-(4-nitrobenzoyl)hydrazine-1-carbodithioate (3.5 g, 0.011 mol) was heated under reflux for 6 h in excess of hydrazine hydrate (approximately 30 mL).…”

Section: Synthesis Of 4-amino-5-(4-nitrophenyl)-4h-124triazole-3-thiolmentioning

confidence: 99%

“…3 [13][14]. The d 9 ion was characterized by a large distortion from the octahedral symmetry, and the band was asymmetrical. Several transformations have occurred, and these transitions have emerged, which cannot be easily set without ambiguity.…”

Section: Electronic Spectra Magnetic Susceptibility and Molar Conduct...mentioning

confidence: 99%

Synthesis, Structural Analysis and Thermal Behavior of New 1,2,4-Triazole Derivative and Its Transition Metal Complexes

et al. 2021

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Cobalt(II), nickel(II), and copper(II) complexes containing bidentate ligands )5-(4-nitrophenyl)-4-((4-phenoxybenzylidene)amino)-4H-1,2,4-triazole-3-thiol) could be synthesized by the condensation reaction between 1,2,4-triazole derivative and p-phenoxy benzaldehyde. The ligand and its complexes were characterized by various spectroscopic techniques such as FTIR, UV-visible, 1H and 13C-NMR, element analysis, molar conductance, and magnetic susceptibility test. The new ligand was exploited as a ligand to coordinate with Co(II), Ni(II), and Cu(II) by a molar ratio of 1:2 (metal:ligand). The prepared complexes (C1, C2, and C3) were exposed to thermo-gravimetric analysis (TGA/DTG) under an inert atmosphere to investigate their thermal stability. The ligand (L) degradation was also investigated as a reference. The results indicated that the complexes proposed structures had an octahedral geometry.

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Synthesis, characterization of new 5-(4-nitrophenyl)-4-((4 phenoxybenzylidene)amino)-4H-1,2,4-triazole-3-thiol metal complexes and study of the antibacterial activity

Cited by 5 publications

References 10 publications

Synthesis, Characterization, and Anticancer Potency of Branched Poly (p‐Hydroxy Styrene) Schiff‐Bases

Synthesis, Characterization, and Anticancer Potency of Branched Poly (p‐Hydroxy Styrene) Schiff‐Bases

Synthesis and Characterization of a Novel Azo-Dye Schiff Base and Its Metal Ion Complexes Based on 1,2,4-Triazole Derivatives

Synthesis, Structural Analysis and Thermal Behavior of New 1,2,4-Triazole Derivative and Its Transition Metal Complexes

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