Synthesis and comparative characterization of functionalized nanoporous silica obtained from tetrachloro- and tetraethoxysilane by a sol-gel method

Vorotyntsev, Andrey V.; Марков, А. Н.; Kapinos, Alexander A.; Petukhov, Anton N.; Pryakhina, V. I.; Nyuchev, Alexander V.; Atlaskina, Maria E.; Andronova, A.A.; Markova, Ekaterina A.; Воротынцев, В. М.

doi:10.1080/10426507.2020.1825433

Cited by 7 publications

(4 citation statements)

References 29 publications

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“…Silane precursors commonly used for silica particle synthesis are triethoxysilanes (RTES) and trimethoxysilanes (RMES), where the R group is an organic substitute that varies from methyl, ethyl, octyl to vinyl, 3-mercaptopropyl, 3,3,3-propyl (trifluoro), and glycol-modified silane etc. − The particle size increases proportionally with an increase in the concentration of organosilane. Oh and co-workers have shown the effect of 3-mercaptopropyl trimethoxysilane (MPTMS) concentration on the particle size of silica and obtained well-defined silica particles of 1.2 μm in size by using 0.5 g of MPTMS.…”

Section: Mesoporous Silica Nanoparticles (Msn) Synthesis Structure An...mentioning

confidence: 99%

Ordered Mesoporous Silica Delivering siRNA as Cancer Nanotherapeutics: A Comprehensive Review

Gupta,

Choudhury,

Meena

et al. 2024

ACS Biomater. Sci. Eng.

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Nanosized mesoporous silica has emerged as a promising flexible platform delivering siRNA for cancer treatment. This ordered mesoporous nanosized silica provides attractive features of well-defined and tunable porosity, structure, high payload, and multiple functionalizations for targeted delivery and increasing biocompatibility over other polymeric nanocarriers. Moreover, it also overcomes the lacunae associated with traditional administration of drugs. Chemically modified porous silica matrix efficiently entraps siRNA molecules and prevents their enzymatic degradation and premature release. This Review discusses the synthesis of silica using the sol−gel approach and the advantages with different silica mesostructure. Herein, the factors affecting the synthesis of silica at nanometer scale, shape, porosity and nanoparticle surface modification are also highlighted to attain the desired nanostructured silica carriers. Additional emphasis is given to chemically modified silica delivering siRNA, where the silica nanoparticle surface was modified with different chemical moieties such as amine modified with (3-aminoropyl) triethoxysilane, polyethylenimine, chitosan, poly(ethylene glycol), and cyclodextrin polymer modification to attain high therapeutic loading, improved dispersibility and biocompatibility. Upon systemic administration, ordered mesoporous nanosized silica encounters blood cells, immune cells, and organs mainly of the reticuloendothelial system (RES). Thereby, biocompatibility and biodistribution of silica based nanocarriers are deliberated to design principles for smart and efficacious nanostructured silica-siRNA carriers and their clinical trial status. This Review further reports the future scopes and challenges for developing silica nanomaterial as a promising siRNA delivery vehicle demanding FDA approval.

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Section: Mesoporous Silica Nanoparticles (Msn) Synthesis Structure An...mentioning

confidence: 99%

Ordered Mesoporous Silica Delivering siRNA as Cancer Nanotherapeutics: A Comprehensive Review

Gupta,

Choudhury,

Meena

et al. 2024

ACS Biomater. Sci. Eng.

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“…The intensity of adsorbate bands in the Kubelka-Munk (K-M) function units is directly related to the adsorbate molecules' concentration. Figure 5 shows the IR spectra of DRIFTS in K-M units of the previously studied silica samples obtained from STC and TEOS [35], in comparison with the samples from TCS researched in this work. methylimidazole, 2-methylimidazole and 4-methylimidazole.…”

Section: Sample Characteristicsmentioning

confidence: 99%

“…To reduce the cost of the technology, it is advisable to consider silicon tetrachloride (STC) and trichlorosilane (TCS) as precursors since they have a lower cost compared to tetraethoxysilane (TEOS) and are obtained by the esterification of silicon tetrachloride with ethanol [ 34 ]. In [ 35 ], a comparison of two silica precursors (TEOS and STC) was presented, and the influence of various factors on the morphology and structural characteristics of the final product was analyzed. It has been shown that nanoporous silicon dioxide obtained from STC is characterized by a larger specific surface area and a higher concentration of silanol groups.…”

Section: Introductionmentioning

confidence: 99%

Bifunctional Silica-Supported Ionic Liquid Phase (SILP) Catalysts in Silane Production: Their Synthesis, Characterization and Catalytic Activity

Abarbanel,

Suvorov,

Petukhov

et al. 2023

IJMS

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A mesoporous silica support was synthesized using the sol–gel method from trichlorosilane. There is a tendency for the specific surface area and the proportion of silica particles mesopores to increase during all stages of sol–gel synthesis. It has been shown that the insertion of hexane and toluene, as additional solvents, into the structure-forming polyethylene glycol, makes it possible to regulate the pore size and specific surface area of silica. Silica functionalization was carried out using SILP technology. The activities of the catalytic systems based on polymer and inorganic supports immobilized by imidazole-based ionic liquids during the trichlorosilane disproportionation reaction were compared. There is a tendency for the monosilane yield for catalytic systems based on an inorganic support to increase. We identified the most promising catalyst in terms of monosilane yield and proposed a bifunctional catalyst that exhibited activity in two parallel reactions: trichlorosilane disproportionation and silicon tetrachloride hydrogenation.

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“…In most cases, the synthesis of silica fillers for composite systems is implemented by the sol-gel method with the use of a catalyst to accelerate the process [17][18][19]. In the process of silica filler production, the base catalyst is most often used due to the fact that it provides the necessary dynamics of the sol-gel system during tetraethoxysilane (TEOS) hydrolysis to form spherical structures of a regular shape [20,21].…”

Section: Introductionmentioning

confidence: 99%

Effect of a Tetraethoxysilane Hydrolysis Reaction Catalyst on the Precipitation of Hydrolysis Products in the Pores of a Polyimide Track Membrane

et al. 2023

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This paper presents the results of obtaining a composite film based on polyimide track membranes filled with a silica filler, although the issue of the deposition of this filler in the pores of the given membranes remained unexplored. The filler was obtained by hydrolysis of tetraethoxysilane using an alkaline and acid catalyst. This paper presents the results of the effect of the tetraethoxysilane hydrolysis reaction catalyst on the precipitation of hydrolysis products in the pores of the polyimide track membrane. The factors influencing the formation of silicon oxide nanofibers within the matrix template (polyimide track membrane) are determined. It was found that the use of an acid catalyst provides the highest rates of filling, while when using an alkaline catalyst, the filling is practically not observed, and only single pores are filled. The properties of the composite film obtained were investigated. SEM images of the surface and chip of the composite while using alkaline and acid catalyst are presented. The spatial structure of composite films based on track membranes was investigated by FTIR spectroscopy. The hydrolysis of tetraethoxysilane in an acid medium significantly decreases the optical density index of the membranes and simultaneously increases their light transmission index. The greatest changes are observed in the range of 500–1000 nm, and there are no detectable changes in the range of 340–500 nm. When using an alkaline catalyst, there is not the same significant decrease in the relative optical density index D.

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Synthesis and comparative characterization of functionalized nanoporous silica obtained from tetrachloro- and tetraethoxysilane by a sol-gel method

Cited by 7 publications

References 29 publications

Ordered Mesoporous Silica Delivering siRNA as Cancer Nanotherapeutics: A Comprehensive Review

Ordered Mesoporous Silica Delivering siRNA as Cancer Nanotherapeutics: A Comprehensive Review

Bifunctional Silica-Supported Ionic Liquid Phase (SILP) Catalysts in Silane Production: Their Synthesis, Characterization and Catalytic Activity

Effect of a Tetraethoxysilane Hydrolysis Reaction Catalyst on the Precipitation of Hydrolysis Products in the Pores of a Polyimide Track Membrane

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