Synthesis and crystal structure of novel [1,2,4]oxadiazolo[5,4‐d][1,5]benzothiozepine derivatives containing pyrazole moiety

Abstract

A series of new substituted‐[1,2,4]oxadiazolo[5,4‐d][1,5]benzothiazepine derivatives containing pyrazole ring 4/4′ was synthesized by substituted‐pyrazolo[1,5]benzothiazepines 2/2′ and substituted‐benzohydroximinoyl chlorides 3 through the 1,3‐dipolar cycloaddition reaction in the presence of Et3N at room temperature, and characterized by MS, IR, 1H NMR and elemental analyses. In addition, the structure of 4′l was determined by X‐ray crystallography. J. Heterocyclic Chem., 2011.

Synthesis of Benzoxazepine Derivatives From Pyrazole-Chalcone via a Simple and Convenient Protocol Using Basic Alumina as Solid Support

“…These derivatives are well-known pharmacophores showing capable properties against various diseases such as antipsychotic 20 , central nervous system damage 21 and anticancer activities 22 . Usually, benzoxazepine derivatives preparation involves multistep synthesis [23][24][25] . Therefore, an efficient, eco-friendly, straightforward synthetic method toward benzoxazepine still represents an interesting assignment for chemists.…”

Synthesis of Novel Benzotriazoloazepine Derivatives

“…Benzazepine derivatives have exhibit broad pharmacological activity . Synthesis and modification of their structure is one of the research focuses in organic chemistry nowadays . According to the literature reports, triazole compounds have wide variety of biological activities, the introduction of triazole ring to some active molecules may significantly improve the biological activity of the parent molecule due to the superposition of biological activity .…”