Reaction of 1,5-benzothiazepines, containing 2-phenyl-1,2,3-triazole 2a-d, with aryl nitrile oxides in CH2 Cl2 at room temperature leads to a series of novel 1,2,4-oxadiazolo[4,5-d]-1,5-benzothiazepine derivatives 3a-l in good yields. The products were characterized by IR, 1H NMR, MS, elemental analyses, X-ray and their spectrum characters were discussed.

A series of new substituted‐[1,2,4]oxadiazolo[5,4‐d][1,5]benzothiazepine derivatives containing pyrazole ring 4/4′ was synthesized by substituted‐pyrazolo[1,5]benzothiazepines 2/2′ and substituted‐benzohydroximinoyl chlorides 3 through the 1,3‐dipolar cycloaddition reaction in the presence of Et3N at room temperature, and characterized by MS, IR, 1H NMR and elemental analyses. In addition, the structure of 4′l was determined by X‐ray crystallography. J. Heterocyclic Chem., 2011.

Synthesis and Structure Characterization of New [1,2,4]Triazolo[5,4-d][1,5]benzothiazepine Derivatives Through 1,3-Dipolar Cycloaddition Reaction. -Novel heterocycles (III) are obtained regioselectively by 1,3-dipolar cycloaddition of in situ generated nitrilimines to benzothiazepines (I). The structure of compound (IIIc) is proved by X-ray analysis. -(WU, X.-L.; LIU*, F.-M.; ZHOU, Y.-L.; J. Heterocycl. Chem. 48 (2011) 2, 368-372, http://dx.

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