Synthesis and crystal structure of bicopper(II) complexes: The influence of bridging ligands on DNA/BSA binding behaviors and in vitro antitumor activity

Li, Xiaowen; Zhao, Xihui; Li, Yan‐Tuan; Wu, Zhi‐Yong

doi:10.1016/j.ica.2019.01.026

Cited by 10 publications

(5 citation statements)

References 54 publications

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“…The study of electronic adsorption is an effective method for investigating structural changes in proteins ( Li et al, 2019 ). The absorption spectrum of BSA in an aqueous solution has two absorption peaks, which combine the transfer of π → π * amino acids Trp, Phe, and Tyr (weak UV-vis band at 280 nm) and the BSA framework (sharp band at 212 nm) ( Shen et al, 2015 ).…”

Section: Resultsmentioning

confidence: 99%

“…The study of electronic adsorption is an effective method for investigating structural changes in proteins (Li et al, 2019). The…”

Section: Absorption Studiesmentioning

confidence: 99%

“…DNA has recently emerged as the principal biological target for some anticancer medications as a result of advancements in medical technology. In numerous study areas, including medicinal chemistry, cancer treatment, and biochemistry, the interaction of chemicals with DNA is of interest and significance ( Li et al, 2019 ). Additionally, BSA, one of the major serum albumin proteins, performs crucial physiological tasks such nutrient absorption, buffering, and transport ( Kucuk and Gulcin, 2016 ; Kocyigit et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

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RETRACTED: Studying the interaction between the new neodymium (Nd) complex with the ligand of 1,10-phenanthroline with FS-DNA and BSA

Raeisi Vanani,

Asadpour,

Aramesh-Boroujeni

et al. 2023

Front. Chem.

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To learn more about the chemotherapeutic and pharmacokinetic properties of a neodymium complex containing 1,10-phenanthroline (dafone), In vitro binding was investigated with bovine serum albumin and fish-salmon DNA, using a variety of molecular modeling research and biophysical approaches. A variety of spectroscopic techniques including fluorescence and absorption were used to investigate the interplay between DNA/BSA and the neodymium complex. The findings revealed that the Nd complex had a high affinity for BSA and DNA interplays through van der Waals powers. In addition, the binding of the Nd complex to FS-DNA mainly in the groove binding mode clearly reflects with iodide quenching studies, ethidium bromide (EtBr) exclusion assay, ionic strength effect, and viscosity studies. It was observed that the Nd complex binds to FS-DNA through a minor groove with 3.81 × 105 (M−1). Also, Kb for BSA at 298 K was 5.19×105 (M−1), indicating a relatively high affinity of the Nd complex for DNA and BSA. In addition, a competitive study of a docking investigation revealed that the neodymium complex interacts at BSA site III. The results obtained from the binding calculations are well consistent with the experimental findings. Also, cytotoxicity studies of Nd complex were performed in MCF-7 and A-549 cell lines and the results show that this new complex has a selective inhibitory effect on the growth of various cancer cells.

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Section: Resultsmentioning

confidence: 99%

“…The study of electronic adsorption is an effective method for investigating structural changes in proteins (Li et al, 2019). The…”

Section: Absorption Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

RETRACTED: Studying the interaction between the new neodymium (Nd) complex with the ligand of 1,10-phenanthroline with FS-DNA and BSA

Raeisi Vanani,

Asadpour,

Aramesh-Boroujeni

et al. 2023

Front. Chem.

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“…The electronic absorption study is a useful method to investigate the protein structural change. 44 The absorption spectra of the aqueous BSA solution has two absorption peaks, which are referred to the framework conformation of BSA (sharp band at 212 nm) and the p / p* transition of Tyr, Phe, and Trp amino acids (weak UV-vis band at 280 nm). 45 The BSA electronic spectra (10 mM) in the absence and presence of the Yb-complex (0.5-6.5 mM) are indicated in Fig.…”

Section: Protein-bindingmentioning

confidence: 99%

Parent and nano-encapsulated ytterbium(iii) complex toward binding with biological macromolecules, in vitro cytotoxicity, cleavage and antimicrobial activity studies

et al. 2020

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“…It is very important to state that biological systems rely on this type of interaction to create photoreceptors, links with peptides and are capable to withdraw a system inside a hydrophobic cavity inside a protein. [12,13] The oxidation state of the metal is also an important point to understand the behavior of the systems. Cu ions can exist in both an oxidized cupric (Cu 2+ ), or reduced, cuprous (Cu + ), state.…”

Section: Introductionmentioning

confidence: 99%

On the nature of the interaction of copper hydride and halide with substituted ethylene and acetylene

2020

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The association of Cu-X (X=-H, -Cl and -F) with H2CCHCHmYn and HCCCHmYn (Y= -Cl, -F, -OH, -CH3) has been studied at high level of theory. The Density Functional Theory (DFT) at B3LYP/6-311G(d,p)//B3LYP/6-311+G(3df,2p) level has been chosen to calculate the structure and the relative stability of 24 different complexes. The interaction of Cu-F with the derivatives of ethylene and acetylene was found very strong, with interaction energies close to those of conventional covalent bonds. In all complexes, the most stable structure was found when Cu-X is positioned on the unsaturated CC bond, forming a threemembered ring that leads to longer CC bond distances. Both ethylene and acetylene complexes show similar trends of interaction energies with respect to the same moiety. All electronic indexes analyzed by means of the QTAIM, ELF and NBO formalisms, indicate that the strength of the interaction should increase with the number of withdrawing substituents in both series of compounds.

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Synthesis and crystal structure of bicopper(II) complexes: The influence of bridging ligands on DNA/BSA binding behaviors and in vitro antitumor activity

Cited by 10 publications

References 54 publications

RETRACTED: Studying the interaction between the new neodymium (Nd) complex with the ligand of 1,10-phenanthroline with FS-DNA and BSA

RETRACTED: Studying the interaction between the new neodymium (Nd) complex with the ligand of 1,10-phenanthroline with FS-DNA and BSA

Parent and nano-encapsulated ytterbium(iii) complex toward binding with biological macromolecules, in vitro cytotoxicity, cleavage and antimicrobial activity studies

On the nature of the interaction of copper hydride and halide with substituted ethylene and acetylene

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