Synthesis and cytostatic activity of Pt(II) complexes of intramolecularly coordinated phosphine and stibine ligands

Abstract

H 3 ]SbPh 2 }PtCl 2 (6) as the result of different ability of the starting compounds 1-3 to complex platinum centre. Compounds 1-6 were characterized by 1 H, 13 C and 31 P NMR spectroscopy and electrospray ionization mass spectrometry, and molecular structures of 3-6 were determined by X-ray diffraction analysis. The substitution reactions of complexes 4-6 were also studied. The reaction of 5 and 6 with NaI yielded complexes {[2,6-(Me 2 NCH 2 ) 2 C 6 H 3 ]PPh 2 }PtI 2 (7) and {[2,6-(Me 2 NCH 2 ) 2 C 6 H 3 ]SbPh 2 }PtI 2 (8), while the same reaction of 4 with NaI did not proceed. As the compounds 7 and 8 structurally resemble cisplatin, complex {{[2-(Me 2 NCH 2 )-6-(Me 2 NHCH 2 )C 6 H 3 ]PPh 2 }PtCl 2 } + Cl À (9) was prepared as water-soluble platinum complex. The cytotoxic effect of complex 9 was evaluated on human T-lymphocytic leukemia cells MOLT-4 (IC 50 = 27.6 AE 1.8 mmol l À1 ) and human promyelocytic leukemia HL-60 (IC 50 = 55.9 AE 4.9 mmol l À1 ).

Phosphinimine complex of organotin(IV) compounds stabilized by O,C,O-chelating ligand

“…The starting compound [2,6-( t BuOCH 2 ) 2 C 6 H 3 ]PPh 2 (1) was prepared according to literature [9] (2) 0.11 mL of Me 3 SiN 3 (0.85 mmol) was added to toluene solution (10 mL) of 1 (0.24 g; 0.56 mmol) and reaction mixture was heated to 85 C. The reaction was monitored by 31 P NMR spectroscopy and the reaction was complete in 7 days. The solvent was evaporated in reduced pressure to form orange viscous oil of 2 (yield 0.61 g; 97%).…”

“…In general, the synthesis of phosphinimine ligands is based on easy oxidation of phosphine ligands by Me 3 SiN 3 and all given examples are limited to study the effects of sterical demanding phosphinimine ligands, while the synthesis of an intramolecularly coordinated phosphinimine ligands is still unknown. Previously we have reported synthesis of an ether functionalized phosphine ligand {2,6-( t BuOCH 2 ) 2 C 6 H 3 }PPh 2 (1) and its coordination ability towards MCl 2 (M is Pd, Pt) (Chart 1) [9].…”

Synthesis and Structure of Tris(2-methoxyphenyl)antimony Bis(2,5-difluorobenzoate)

“…Наличие вакантных d-орбиталей у атомов сурьмы позволяет образовывать дополнительные координационные связи с лигандами, содержащими пространственно доступные атомы с неподеленными электронными парами, что приводит к увеличению координационного числа металла и часто влияет на реакционную способность соединений. Однако арильные соединения сурьмы, содержащие в фенильных заместителях такие потенциальные координирующие центры, как атомы азота [3][4][5][6][7][8][9][10] или кислорода [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]…”