Synthesis and Cytotoxic Activity Evaluation of Novel Derivatives of Murrayafoline A

Anh, Le Duc

doi:10.15625/2525-2518/54/2c/11880

JST

2018

DOI: 10.15625/2525-2518/54/2c/11880

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Synthesis and Cytotoxic Activity Evaluation of Novel Derivatives of Murrayafoline A

Le Duc Anh

Abstract: Two new conjugates of murrayafoline A with zerumbone and artemisinin 3, 11 were prepared by N-alkylation, in which, compound 3 was synthesized from two consecutive Nalkylation reactions. Their cytotoxicity was evaluated on four human cancer cell lines Hep-G2, LU, RD and Fl. The result showed that both compounds exhibited no activity against the tested cell lines.

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2021

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Optimization of Murrayafoline A ethanol extraction process from the roots of Glycosmis stenocarpa, and evaluation of its Tumorigenesis inhibition activity on Hep-G2 cells

et al. 2021

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Glycosmis stenocarpa is a species of shrub found in the Northern provinces of Vietnam. Its roots contain different carbazolic derivatives, mainly Murrayafoline A (Mu-A), which exhibits valuable biological activities. In this study, we performed an extraction of Mu-A from the roots of G. stenocarpa and optimized this process using response surface methodology (RSM) according to a central composite design, with three independent parameters including extraction time (min), extraction temperature (°C), and solvent/material ratio (mL/g). Two dependent variables were the Mu-A content (mg/g raw materials) and extraction efficiency (%). The optimal conditions to extract Mu-A were found to be as follows: extraction temperature, 67°C; extraction time, 165 min; and solvent/material ratio, 5:1. Under these conditions, the Mu-A content and extraction efficiency were 38.94 ± 1.31 mg/g raw materials and 34.98 ± 1.18%, respectively. Mu-A exhibited antiproliferation and antitumor-promoting activity against the HepG-2 cell line. The present optimization work of Mu-A extraction from G. stenocarpa roots contributed to the attempt of designing a large-scale extraction process for the compound and further exploitation of its potential in vivo applications.

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Optimization of Murrayafoline A ethanol extraction process from the roots of Glycosmis stenocarpa, and evaluation of its Tumorigenesis inhibition activity on Hep-G2 cells

et al. 2021

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Synthesis and Cytotoxic Activity Evaluation of Novel Derivatives of Murrayafoline A

Cited by 1 publication

References 10 publications

Optimization of Murrayafoline A ethanol extraction process from the roots of Glycosmis stenocarpa, and evaluation of its Tumorigenesis inhibition activity on Hep-G2 cells

Optimization of Murrayafoline A ethanol extraction process from the roots of Glycosmis stenocarpa, and evaluation of its Tumorigenesis inhibition activity on Hep-G2 cells

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