Synthesis and cytotoxicity evaluation of highly functionalized pyranochromenes and pyranopyrans

Inhibition of cell proliferation and induction of apoptosis in K562 human leukemia cells by the derivative (3-NpC) from dihydro-pyranochromenes family

“…In recent years, the cytotoxic activities of tetrahydro-pyranochromenes and dihydro-pyranopyran derivatives against various cancer cell lines have been demonstrated. Interestingly, different cells responded differently to the compounds in a cell type dependent manner (Emmadi et al, 2012;Heidary Alizadeh et al, 2010). The discovery and characterization of 4-aryl-4H-chromenes family as potent inducers of apoptosis in T47D and Jurkat cell lines was also reported (Kemnitzer et al, 2004).…”

Zn(L-proline)2: An efficient and reusable organocatalyst for the synthesis of polyfunctionally substituted pyrans and 2-amino-4-aryl-8-oxo-4,8-dihydropyrano[3,2-b]pyran derivatives

“…Polyfunctionally substituted pyrans and pyrano [3,2b]pyran derivatives are interesting privileged scaffolds of heterocyclic compounds in fields related to biological, medicinal and industrial importance. They possess a wide range of activities including anticancer, antihypertensive and anti-HIV [1][2][3][4][5][6]. In addition, they were efficiently utilized as pigments and biodegradable agrochemicals [7,8].…”

Synthesis and characterization of amino glucose-functionalized silica-coated NiFe2O4 nanoparticles: a heterogeneous, new and magnetically separable catalyst for the solvent-free synthesis of pyrano[3,2-c]chromen-5(4H)-ones

“…Pyranochromenes are a class of important heterocycles with a wide range of pharmaceutical and biological properties such as anti-coagulant, spasmolytic, analgesic, myorelaxant, anticancer, cytotoxic, anti-HIV, anti-microbial, anti-tuberculosis, diuretic and anti-anaphylactic activity. [1][2][3][4][5][6][7][8][9] Moreover, they can be used as cognitive enhancers for the treatment of neurodegenerative diseases, including Huntington's disease, schizophrenia and myoclonus disease, amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, AIDS associated dementia and Down's syndrome. 1 They can act also as additives in perfumes, food, cosmetics, optical brighteners, dispersed uorescence and laser dyes.…”