Synthesis and electro-catalytic evaluation of Ti(IV)-anchored heterogeneous mesoporous material for uric acid analysis

Shenbagapushpam, Muthumanickam; Muthukumar, Thennila; Paulpandian, Muthu Mareeswaran; Selvakumar, Kodirajan

doi:10.1016/j.microc.2021.106672

Cited by 4 publications

(3 citation statements)

References 69 publications

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“…Cre-PAni/Nb 2 O 5 modified electrodes exhibit a decrease in E corr (59 mV) and an increase in I corr (1.16 μA/cm 2 ) with improved electrocatalytic properties. Furthermore, a higher cathodic Tafel slope (β a ) of 52.6 mV/dec after Cre-PAni/Nb 2 O 5 modification indicates its excellent electrocatalytic properties. , …”

Section: Results and Discussionmentioning

confidence: 99%

“…Furthermore, a higher cathodic Tafel slope (β a ) of 52.6 mV/dec after Cre-PAni/Nb 2 O 5 modification indicates its excellent electrocatalytic properties. 39,40 The electroactive surface area (A real ) and heterogeneous rate constant (K°) of Cre-PAni/Nb 2 O 5 electrodes are determined (Figure S4c-d) by the following eqs 1 and 2, respectively: 41,42 I n A D Cv 2.69 10…”

Section: ■ Introductionmentioning

confidence: 99%

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Target-Imprinted Polyaniline/Nb₂O₅ Nanoparticles as Electrochemical Interfaces for Monitoring Kidney Function

Saddique,

Saeed,

Afzal

2024

ACS Appl. Nano Mater.

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Timely detection of creatinine (Cre), a biomarker for kidney function and muscle health, is crucial for the diagnosis of chronic kidney disease (CKD), particularly in point-of-care (POC) settings. In this study, we present the design of Cre-imprinted, conductive polyaniline/Nb 2 O 5 nanostructures, termed Cre-PAni/Nb 2 O 5 , as an electrochemical interface for the rapid quantification of Cre in human saliva. Cre-PAni/Nb 2 O 5 is synthesized via in situ oxidative polymerization of diphenylamine-cross-linked aniline on the surface of monoclinic Nb 2 O 5 nanoparticles and fabricated on screen-printed Au disposable electrodes to develop cost-efficient Cre-PAni/ Nb 2 O 5 sensors. The microscopic characterizations of the Cre-PAni/Nb 2 O 5 sensor demonstrate the composite architecture of the synthesized Cre-PAni/ Nb 2 O 5 nanoparticles and a granular surface morphology with irregular spherical shapes. Electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) reveal that Cre-PAni/Nb 2 O 5 possesses outstanding electrocatalytic properties, with lower interfacial resistance and superior electron transfer kinetics, compared to pristine, nonimprinted PAni and PAni/Nb 2 O 5 as well as Cre-PAni sensors. Differential pulse voltammetry (DPV) confirms an increase in the electrooxidation current with rising Cre concentrations (0−1000 nM). Notably, the Cre-PAni/Nb 2 O 5 sensor displays 3.68 μAcm −2 nM −1 sensitivity, with detection and quantification limits of 127 pM and 385 pM, respectively. Furthermore, the sensor exhibits remarkable Cre selectivity and 97.41 ± 2.83% Cre recovery in real saliva samples. Hence, disposable Cre-PAni/Nb 2 O 5 sensors enable routine monitoring of kidney function and early CKD diagnosis through economical, noninvasive POC testing.

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Section: Results and Discussionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Target-Imprinted Polyaniline/Nb₂O₅ Nanoparticles as Electrochemical Interfaces for Monitoring Kidney Function

Saddique,

Saeed,

Afzal

2024

ACS Appl. Nano Mater.

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“…in DMF was stirred at 60 ºC for 1 hour as reported in literature [100]. Ti-MCM-41 catalyst was synthesized based on our previous report [101]. Ti-MCM-41 catalyst was used as catalyst for the synthesis of imine [99].…”

Section: Synthesis Of N-propargyl Isatin and Pqimentioning

confidence: 99%

Active Hydrogen Free, Z-isomer selective, isatin derived “Turn on” fluorescent dual anions sensor

Shenbagapushpam,

Ashwin,

Mareeswaran

et al. 2024

Preprint

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An efficient 1-(prop-2-yn-1-yl)-3-(quinolin-3-ylimino)indolin-2-one (PQI) fluorescence "on-off" sensor for anions has been designed to detect dual F- and NO3- ions anions in an aqueous medium without interference. Superior UV light sensing activity against F- and NO3- ions is exhibited by the Z-isomer of the isatin-based π-conjugated quinoline isomer, which is free of Lewis acid and active hydrogen sites. The act of turning on the fluorescence is accomplished using the PET "on-off" mechanism. The non-covalent interactions that mediate the interaction between the probe molecule and anions are thought to be the low electron density covalently bonded isatin N-methylene moiety (-N-CH2-) of the propargyl group of the probe molecule for F- ions and the terminal acidic proton of propargyl for NO3- ions, respectively. The forms of anion binding with PQI are explained by conceivable mechanisms as shown by 1H and 13C NMR titrations. The selectivity of anions sensing may be affected by the bucked structure of the Z-isomer. The computed association constant values for PQI and F- and NO3- ions are 2.5 × 104 M-1 and 2.2 × 103 M-1, respectively, indicating strong interaction between PQI and anions. The relationship between anions and probes is investigated using a jobs plot analysis, and the findings indicate that F- and NO3- ions are in a 1:1 complexation with PQI. The calculation indicates that the probe's limit of detection (LOD) for F- and NO3- ions is 6.91 × 10-7 M-1 and 9.93 × 10-7 M-1, respectively. The low limit of detection (LOD) of the suggested PQI fluorophore is within the WHO-recommended limit for both F- and NO3- ions.

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An Efficient Synthesis of Heterogeneous and Hard Bound Ti^IV‐MCM‐41 Catalyzed Mannich Bases and π‐Conjugated Imines

Shenbagapushpam¹,

Muthukumar²,

Yuvaraj

et al. 2021

ChemistrySelect

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A heterogeneous and hard bound TiIV anchored MCM‐41 material has been successfully evaluated for catalytic applications in the one pot synthesis of highly functionalized β‐amino ketones and quinoline appended π‐conjugated imines via Mannich reaction and condensation reaction, respectively. The synthetic transformation was successfully catalyzed via the dual Bronsted and Lewis acetic nature of the Ti‐MCM‐41 material that provided excellent yields of the desired products. The heterogeneous catalyst shows good catalytic performance, facile separation from the reaction mixture and can be reused in more than five catalytic cycles without any significant loss in the yield.

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Synthesis and electro-catalytic evaluation of Ti(IV)-anchored heterogeneous mesoporous material for uric acid analysis

Cited by 4 publications

References 69 publications

Target-Imprinted Polyaniline/Nb₂O₅ Nanoparticles as Electrochemical Interfaces for Monitoring Kidney Function

Target-Imprinted Polyaniline/Nb₂O₅ Nanoparticles as Electrochemical Interfaces for Monitoring Kidney Function

Active Hydrogen Free, Z-isomer selective, isatin derived “Turn on” fluorescent dual anions sensor

An Efficient Synthesis of Heterogeneous and Hard Bound Ti^IV‐MCM‐41 Catalyzed Mannich Bases and π‐Conjugated Imines

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Synthesis and electro-catalytic evaluation of Ti(IV)-anchored heterogeneous mesoporous material for uric acid analysis

Cited by 4 publications

References 69 publications

Target-Imprinted Polyaniline/Nb2O5 Nanoparticles as Electrochemical Interfaces for Monitoring Kidney Function

Target-Imprinted Polyaniline/Nb2O5 Nanoparticles as Electrochemical Interfaces for Monitoring Kidney Function

Active Hydrogen Free, Z-isomer selective, isatin derived “Turn on” fluorescent dual anions sensor

An Efficient Synthesis of Heterogeneous and Hard Bound TiIV‐MCM‐41 Catalyzed Mannich Bases and π‐Conjugated Imines

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Product

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Target-Imprinted Polyaniline/Nb₂O₅ Nanoparticles as Electrochemical Interfaces for Monitoring Kidney Function

Target-Imprinted Polyaniline/Nb₂O₅ Nanoparticles as Electrochemical Interfaces for Monitoring Kidney Function

An Efficient Synthesis of Heterogeneous and Hard Bound Ti^IV‐MCM‐41 Catalyzed Mannich Bases and π‐Conjugated Imines