Synthesis and electron-transfer properties of benzimidazole-functionalized ruthenium complexes for highly efficient dye-sensitized solar cells

Huang, Wei‐Kai; Cheng, Chien-Fu; Chang, Shu-Mei; Lee, Yuan‐Pern; Diau, Eric Wei‐Guang

doi:10.1039/c0cc03517c

Cited by 77 publications

(41 citation statements)

References 23 publications

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“…were synthesized adapting previously reported procedures (see Experimental section). The new Au(III) complex 4 was obtained in 82% yield by reaction between 1-methyl-2-(pyridin-2-yl)-benzimidazole17 in MeCN with an equimolar aqueous solution of NaAuCl4 and an excess of PF6 at room temperature (r.t.) for 3 h, and characterized by various methods. The gold complexes were tested for their AQP1 and AQP3 inhibition properties in hRBC by stopped-flow spectroscopy.…”

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confidence: 99%

The mechanism of aquaporin inhibition by gold compounds elucidated by biophysical and computational methods

et al. 2017

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The inhibition of water and glycerol permeation via human aquaglyceroporin-3 (AQP3) by gold(iii) complexes has been studied by stopped-flow spectroscopy and, for the first time, its mechanism has been described using molecular dynamics (MD), combined with density functional theory (DFT) and electrochemical studies. The obtained MD results showed that the most effective gold-based inhibitor, anchored to Cys40 in AQP3, is able to induce shrinkage of pores preventing glycerol and water permeation. Moreover, the good correlation between the affinity of the Au(iii) complex to Cys binding and AQP3 inhibition effects was highlighted, while no influence of the different oxidative character of the complexes could be observed.

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confidence: 99%

The mechanism of aquaporin inhibition by gold compounds elucidated by biophysical and computational methods

et al. 2017

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“…The library of functionalised pyridylbenzimidazole ligands L1-L9 has been obtained by nucleophilic substitution on the non-coordinated nitrogen atom of the commercially available pyridylbenzimidazole by reaction with a halogenated substituent (R-X) in the presence of a base (Scheme S1, Supplementary Materials) [21]. Several types of functional groups have been envisaged to study the influence of both the steric hindrance and the electronic effect on the biological properties of the final gold complexes.…”

Section: Synthesis and Characterization Of Au(iii) Complexesmentioning

confidence: 99%

Gold(III) Pyridine-Benzimidazole Complexes as Aquaglyceroporin Inhibitors and Antiproliferative Agents

et al. 2018

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Gold compounds have been proven to be novel and versatile tools for biological applications, including as anticancer agents. Recently, we explored the potential of Au(III) complexes with bi-dentate N-donor ligands as inhibitors of the membrane water and glycerol channels aquaporins (AQPs), involved in different physiological and pathophysiological pathways. Here, eight new Au(III) complexes featuring a pyridine-benzimidazole scaffold have been synthesized and characterized via different methods. The stability of all the compounds in aqueous solution and their reactivity with glutathione have been investigated by UV–visible spectroscopy. The Au(III) compounds, tested for their AQPs inhibition properties in human Red Blood Cells (hRBC), are potent and selective inhibitors of AQP3. Furthermore, the compounds’ antiproliferative effects have been studied in a small panel of human cancer cells expressing AQP3. The complexes show only very moderate anticancer effects in vitro and are mostly active against the melanoma A375 cells, with marked expression of AQP3 at the level of the nuclear membrane. In general, the AQP3 inhibition properties of these complexes hold promises to develop them as chemical probes to study the function of this protein isoform in biological systems.

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“…They have attracted special attention due to their important biological or pharmacological properties [1][2][3][4][5][6][7][8] and their wide field of application in different areas of medicine [9][10][11][12] and agriculture 13 . It was reported that the 1,5-benzodiazepines and its derivatives present interesting pharmacological and therapeutic properties.…”

Section: Introductionmentioning

confidence: 99%

Green and efficient method for the synthesis of 1,5-benzodiazipines using phosphate fertilizers as catalysts under free solvent

Sibous¹,

Ghailane²,

Serrar³

et al. 2017

Mediterr.J.Chem.,

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Three-component reaction in one pot transformation of aldehydes, ethylacetoacetate and o-phenylenediamine was employed for the synthesis, under solvent-free, of 1,5-benzodiazepine derivatives using fertilizers mono-ammonium phosphate (MAP), di-ammonium Phosphate (DAP) and triple super phosphate (TSP) as safe, clean, and recyclable catalysts. The synthesis method seems to be operationally simple and provides access to a variety of 1,5-benzodiazepines with excellent yields in a short reaction time.

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Synthesis and electron-transfer properties of benzimidazole-functionalized ruthenium complexes for highly efficient dye-sensitized solar cells

Cited by 77 publications

References 23 publications

The mechanism of aquaporin inhibition by gold compounds elucidated by biophysical and computational methods

The mechanism of aquaporin inhibition by gold compounds elucidated by biophysical and computational methods

Gold(III) Pyridine-Benzimidazole Complexes as Aquaglyceroporin Inhibitors and Antiproliferative Agents

Green and efficient method for the synthesis of 1,5-benzodiazipines using phosphate fertilizers as catalysts under free solvent

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