Synthesis and encapsulation of an amphiphilic thermoresponsive star polymer with β-cyclodextrin and hyperbranched poly(oligo(ethylene glycol)methacrylate) as building blocks

Abstract

Schematic illustrations of the thermally-induced self-assembly and possible encapsulation behaviors with single or multi-guests for PE-CD–POEGMAS.

Thermo-responsiveness and biocompatibility of star-shaped poly[2-(dimethylamino)ethyl methacrylate]-b-poly(sulfobetaine methacrylate) grafted on a β-cyclodextrin core

“…DP n of SBMA is controlled by adjusting the feeding mole ratio of SBMA to CDPD macroinitiator. 1 H NMR result in Fig. 1B conrms the structure of CDPDS polymers.…”

“…Star polymers possess very high molecular weights with threedimensional branched architectures, but a good solubility and low viscosity comparable to the corresponding linear polymers. [1][2][3][4][5] They can self-assemble into various novel topological architectures with interesting physical and chemical properties, [6][7][8] which makes them very promising in various elds including drug delivery, 9 gene delivery, [10][11][12][13][14][15] coatings, 16 and so on. 17 Cyclodextrins (CD) are good junction structures for preparing star polymers, as they offer 18, 21, or 24 hydroxyl groups with high reactive activity for a-, b-, or g-CD, respectively.…”

Synthesis of β-cyclodextrin-based star polymers via a simplified electrochemically mediated ATRP

“…[2,18,[22][23][24][25][26][27][28][29][30][31][32][33][34] Star polymers, consisting of multiple arms linked to a central core, have attracted significant attention, because of their branched architecture, globular shape, and chemically crosslinked structure. [35][36][37][38][39][40][41][42] One approach to prepare star polymers via ATRP is the corefirst technique, which involves the use of a multifunctional initiator, which predetermines the number of arms in the star polymer by the number of initiating sites on the initiator. In addition, the star polymers can easily introduce next segment by chain extension of ω-chain ends (at periphery of the stars) and the final products can be easily purified.…”

Synthesis of hybrid silica nanoparticles grafted with thermoresponsive poly(ethylene glycol) methyl ether methacrylate via AGET-ATRP

“…[42][43][44][45][46][47] Thermosensitive poly(ethylene glycol) methyl ether methacrylate was recently proposed as an attractive alternative to PNI-PAM. 46,[48][49][50][51][52] In fact, the balance between hydrophobic and hydrophilic moieties in the molecular structure of the amphiphilicity polymers is the key-parameter that determines LCST. 53 The side-chains (i.e., EO unit) of poly(ethylene glycol) methyl ether methacrylate are hydrophilic group by forming stabilizing H-bonds with water.…”