Synthesis and evaluation of analgesic, anti-inflammatory and ulcerogenic activities of some triazolo- and 2-pyrazolyl-pyrido[2,3-d]-pyrimidines

Abstract

It is already known that some pyrimido [4,5-b]quinolin-4-one derivatives display an interesting analgesic action in the writhing syndrome and hotplate tests and are not to-

Facile heterocyclic synthesis and antimicrobial activity of polysubstituted and condensed pyrazolopyranopyrimidine and pyrazolopyranotriazine derivatives

“…All microorganisms were purchased from the American Type Culture Collection (manassas, uSA). The newly synthesized compounds (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) were dissolved in dmSO and tested for antimicrobial activity with the agar disk diffusion technique (21), using a 1-cm microplate-well diameter and a solution of 100 mg ml -1 of the test compound. Compound-impregnated disks were placed on an agar plate containing a standard suspension of microorganisms.…”

“…Also, pyrane derivatives are well known antihistaminic agents (11). moreover, it has been noticed that introduction of an additional ring to the pyrimidine core tends to exert a profound influence in conferring novel biological activities in these molecules (12)(13)(14). Pyrimidine and their fused derivatives play an essential role in several biological processes and have considerable chemical and pharmacological importance.…”

Pharmacological significance of triazole scaffold

“…It follows from the literature that the triazole derivatives possess a wide range of pharmacological activities such as antimicrobial [3,4], analgesic [5], anti-inflammatory, local anaesthetic [6], anticonvulsant [7], antineoplastic [8], antimalarial [9], antiviral [10], antiproliferative [11], and anticancer activities [12]. Many triazole-based derivatives are available as medicines [13].…”

Antimicrobial activity of some synthesized glucopyranosyl-pyrimidine carbonitrile and fused pyrimidine systems

“…The precipitated solid was filtered off, washed with water, dried and crystallized from ethanol to give compound 10 or 11. [3,2-d] [1,3]oxazin-6-yl)acetamide (12). -A solution of compound 2 (2.77 g, 0.01 mol) in acetic anhydride (20 mL) was refluxed for 8 h. The reaction mixture was concentrated under reduced pressure.…”