Synthesis and evaluation of antibacterial activity for a series of N-phthaloylglycine derivatives

Begum, Sabira; Nizami, Shaikh Sirajuddin; Saied, Sumayya; Shahid, Syed Muhammad; Basha, Fatima Z.

doi:10.5155/eurjchem.5.4.557-562.1077

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…According to Begum et al [54] study, two series of Nphthaloylglycine derivatives were synthesized under SchottenBaumann conditions. The first series consists of Nphthaloylglycine amides (4ah), and the second one consists of benzimidazole derivatives of Nphthaloylglycine.…”

Section: Resultsmentioning

confidence: 99%

Substituted Pyrazolo[3,4-B]Pyridin-3-Ones and Pyrazolo[3,4-B]Pyridine-5- Carbaldehyde, New One-Pot Synthesis Strategy Amelioration Using Vinamidinium Salts, Antibacterial and Antifungal Activities Promising Environmental Protection

Chtiba¹,

Amri²,

Tazarki³

et al. 2017

J Bacteriol Parasitol

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This review summarizes the current knowledge about the syntheses and biological behavior of some pyrazolo [5,4-b]pyridines. So, an expedient method for the synthesis of 2-phenyl-5-aryl-1,6-dihydropyrazolo [3,4-b]pyridin-3-ones and 2-phenyl-3-oxo-1,6-dihydropyrazolo[3,4-b]pyridine-5-carbaldehyde in a single-step via condensation of vinamidinium salts with 3-amino-1-phenyl-2-pyrazolin-5-one is described according to our recent study with synthesis strategy amelioration. Five derivatives (PYR 1-5 ) were prepared and characterized by spectral data (NMR and MS spectral studies). All the derivatives were studied for their antimicrobial activities. So, we screened for antibacterial effects at 1:2, and 1:4 dilutions by the paper disc diffusion method against respectively Bacteria (Escherichia coli CIP 53126 and Bacillus subtilis CIP 5262) and Fungi (Candida albicans ATCC 10231). Then, we screened for Fungi (Aspergillus niger ATCC 16404) by the dilution method (agar and liquid broth). The agar diffusion method (paper disc and well) and the dilution method (agar and liquid broth) are described.

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Section: Resultsmentioning

confidence: 99%

Substituted Pyrazolo[3,4-B]Pyridin-3-Ones and Pyrazolo[3,4-B]Pyridine-5- Carbaldehyde, New One-Pot Synthesis Strategy Amelioration Using Vinamidinium Salts, Antibacterial and Antifungal Activities Promising Environmental Protection

Chtiba¹,

Amri²,

Tazarki³

et al. 2017

J Bacteriol Parasitol

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“…Complexes of transition metals with amino acids like glycine, have received much attention because they proved biological activity such as antibacterial, antimicrobial or antifungal activities [1][2][3][4]. Glycine derivatives including complexes with different transition metals with antibacterial activity are also known [5,6].…”

Section: Introductionmentioning

confidence: 99%

Complexes of selected transition metal ions with n-modified glycine as ligand

Sacalis¹,

Goga²,

Somesan³

2018

Studia UBB Chemia

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A novel series of transitional metal complexes of Cu(II), Co(II), Ni(II), Zn(II) and Fe(II) with N-modified glycine as ligand provide from phenylserinol were synthesized and characterized via elemental analysis, MS, IR, UV-VIS thermogravimetric analysis and ESR. The thermal stability of the ligand and synthesized complexes was discussed in the 20-1000 o C temperature range. The results indicate that the organic compound acts as a bidentate ligand, its coordination involving the carboxylate oxygen and the nitrogen atom belonging to the amino group of the glycine fragment. The shape of ESR spectrum for cooper complex at room temperature suggest an axial symmetry around the metallic ions (gII=2.427, g┴=2.063).

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In-vitro evaluation and in-silico studies applied on newly synthesized amide derivatives of N-phthaloylglycine as Butyrylcholinesterase (BChE) inhibitors

Begum

Nizami

Mahmood

et al. 2018

Computational Biology and Chemistry

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Synthesis and evaluation of antibacterial activity for a series of N-phthaloylglycine derivatives

Cited by 3 publications

References 22 publications

Substituted Pyrazolo[3,4-B]Pyridin-3-Ones and Pyrazolo[3,4-B]Pyridine-5- Carbaldehyde, New One-Pot Synthesis Strategy Amelioration Using Vinamidinium Salts, Antibacterial and Antifungal Activities Promising Environmental Protection

Substituted Pyrazolo[3,4-B]Pyridin-3-Ones and Pyrazolo[3,4-B]Pyridine-5- Carbaldehyde, New One-Pot Synthesis Strategy Amelioration Using Vinamidinium Salts, Antibacterial and Antifungal Activities Promising Environmental Protection

Complexes of selected transition metal ions with n-modified glycine as ligand

In-vitro evaluation and in-silico studies applied on newly synthesized amide derivatives of N-phthaloylglycine as Butyrylcholinesterase (BChE) inhibitors

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