Synthesis and evaluation of anticancer activity of 2-arylamino-6-trifluoromethyl-3-(hydrazonocarbonyl)pyridines

Triazine as a promising scaffold for its versatile biological behavior

“…One of the difficulties faced in using fullerene derivatives for biological application is its low solubility in water or water miscible solvents, but that can be solved by either introduction of (a) hydrophilic group or (b) ionic species in the molecule. Bacterial inhibition zones developed by fulleropyrrolidines (49) were found to be much bigger in size as compared to s-triazine based schiff base precursors, indicating the contribution of fullerene moiety towards antimicrobial activity. Compound 50 with ionic -NH 3 group was found to be the most active followed by the derivative in which both -NH 2 groups were free, but the activity was decreased with increasing substitution on NH 2 group due to reduced hydrophilicity of the molecule, that in turn decreased the disruption caused to the negatively charged bacterial cell membrane (Fig.…”

“…9). Symmetrical trisubstituted trishaped triazine hydrazones [48] have been evaluated for their in vitro anticancer activity against the human liver carcinoma cell line HepG2 and human cervix carcinoma cell line HeLa and also acted as cytotoxic agents with the ability to prevent cell progression in cancerous cells [49]. Compounds 23a and 23b bearing p-fluoro and p-chloro substituents, exhibited a broad spectrum of antitumor activity against HepG2cells with percent inhibition of 4.32% and 6.41% respectively, while in case of HeLa cell line compounds 23c and 23d bearing p-nitro and p-methoxy substituents showed percent inhibition of 8.36% and 9.37% respectively.…”

Design, synthesis and QSAR study of certain isatin-pyridine hybrids as potential anti-proliferative agents

“…Moreover, it has been selected by the Biological Evaluation Committee of NCI for testing in vivo Hollow Fiber Assay [43]. Recently, Zheng and co-workers developed a novel series of pyridine-bridged analogues of combretastatin-A4 as potential anticancer agents.…”

Synthesis of New Nicotinic Acid Derivatives and Their Evaluation as Analgesic and Anti-inflammatory Agents

“…19) According to literature, the presence of single downfield resonating (8.43-8.99 ppm) imine hydrogen signal accounts for formation of E-isomers exclusively, in DMSOd 6 solution, whereas Z-isomer can be stabilized in less polar solvents by an intramolecular hydrogen bond. 20) In the present study, the spectral data were recorded in DMSO-d 6 , and the signal corresponding to the imine hydrogen was observed in the range of 8. 19-8.93 ppm.…”