Synthesis and evaluation of antimicrobial and antioxidant activity of novel 7‐Aryl‐6H,7H‐ benzo[f]chromeno[4,3‐b]chromen‐6‐one by MgO nanoparticle as green catalyst

Abstract

Using MgO nanoparticle as a recyclable and efficient catalyst, multicomponent reaction of 2-Naphthol, aldehyde derivatives, 4-hydroxycoumarin has led to the synthesis of novel 7-Aryl-6H,7H-benzo[f]chromeno[4,3-b]chromen-6-one derivatives. This study aimed to examine the antimicrobial and antioxidant effects of the synthetic compound in order to reach some benefits, including the synthesis of new derivatives with biological properties, shorter time, high yields, and concordance with green chemistry.

Revisiting Biginelli-like reactions: solvent effects, mechanisms, biological applications and correction of several literature reports

“…A comparable multicomponent Biginelli-like reaction, wherein 2-aminobenzothiazole substitutes the 4-hydroxycoumarin, has also been documented in the literature. 84,[164][165][166][167][168][169] Despite our attempts to reproduce various conditions for synthesizing the MCR adduct (Scheme 6), all efforts yielded DC derivatives, even when attempting to replicate the documented literature conditions, no TCP was obtained. Analysis of the available NMR spectra (or spectral descriptions) strongly suggests the formation of DC rather than any other MCR adduct.…”

Introducing new method for the synthesis of polycyclic compounds containing [1,3]dithiine derivatives, with anticancer and antibacterial activities against common bacterial strains between aquatic and human

“…According to the clinical and laboratory standards institute (CLSI) guidelines M07-A9, M26-A, M02-A11, M44-A, and M27-A2, broth microdilution, and time-kill susceptibility based on the inhibition zone diameter, MIC, and MBC values against L. garvieae (IBRC-M 10900) and E. tarda (IBRC-M 10718) were measured [8][9][10]21,22].…”

Investigation and comparison of biological effects of regioselectively synthesized thiazole derivatives

“…Bacterial, yeast and mold suspensions were respectively prepared in appropriate broth media (Mueller-Hinton for bacteria, Roswell Park Memorial Institute 1640 for fungi) with concentrations of 5 Â 10 5 , 2.5 Â 10 3 and 5 Â 10 4 CFU.mL À1 . Antibacterial activities were checked out via broth microdilution and streak plate methods according to CLSI guidelines M07-A9, M26-A, M27-A2, and M38-A2 [2,[32][33][34] and repeated three times and expressed as the average of three independent experiments. For determination of MIC values, 20 μL of each thiazole with concentration of 40,960 μg.mL À1 in DMSO was added to first and second wells in a row of a 96-well microplate.…”