Synthesis and Evaluation of Cytotoxic Effects of Amino-ester Derivatives of Natural α,β-Amyrin Mixture

Victor, Maurício M.; David, Jorge M.; Santos, Marcelo Andrade Silva; Barreiros, André Luís Bacelar Silva; Barreiros, Marizeth L.; Andrade, Fernanda S.; Carvalho, Adriana Andrade; Luciano, Maria Claudia Santos; Moraes, Manoel O. de; Barros-Nepomuceno, Francisco Washington Araújo; Pessoa, Cláudia

doi:10.21577/0103-5053.20170064

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…The cytotoxicity of the essential oils was determined by the MTT assay, following the protocol described in previous studies (Victor et al, 2017;Guedes et al, 2018). The cytotoxicity was tested against SNB-19 (astrocytoma), HCT-116 (human colon) and PC-3 (human prostate) cancer cell lines, obtained from the National Cancer Institute, Bethesda (MD, USA).…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

Biotechnological potential of essential oils from different chemotypes of Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson

Morais¹,

Sobrinho²,

Liberato³

et al. 2022

BLACPMA

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This study reports the biotechnological importance of seven Lippia albaspecimens collected in different places in Brazil, and evaluation of some activities as larvicidal against Aedesspp., antifungal against dermatophytes; cytotoxicity against SNB-19 (astrocytoma), HCT-116 (human colon) and PC-3 (human prostate) cancer cell lines, and inhibition of the enzyme acetylcholinesterase (AChE).The essential oils, whose extraction yield was about 1.24 w/w ± 0.9%, showed differences in their chemical composition and considered as chemotypes. The essential oils containing neral and geranial as main constituents showed better action against HCT-116 cell lines (IC50 value was 9.22 μg/mL), larvicidal activity against arbovirus vectors (LC50 value against A. aegyptiwas 1.59 μg/mL) and inhibition of AChE (halo inhibition zone was 1 cm). The essential oils containing mainly monoterpenoids showed better antifungal action with MIC values range from 0.15 to 1.25 mg/mL. This chemical and biological characterization may be useful for biotechnological applications.

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Section: Cytotoxicity Assaymentioning

confidence: 99%

Biotechnological potential of essential oils from different chemotypes of Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson

Morais¹,

Sobrinho²,

Liberato³

et al. 2022

BLACPMA

View full text Add to dashboard Cite

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ClTI, a Kunitz trypsin inhibitor purified from Cassia leiandra Benth. seeds, exerts a candidicidal effect on Candida albicans by inducing oxidative stress and necrosis

Araújo

Dias

Costa

et al. 2019

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Analysis of GC-MS from Acetone Extract of Canarium odontophyllum Miq Stem Bark (Dabai)

Ishak,

Rajab,

Basri

2024

Biomed. Pharmacol. J.

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Canarium odontophyllum or dabai is a natural plant found along the river banks of the Sarikei, Kapit and Kanowit in Sarawak and it comes from the 'Burseraceae' family. C. odontophyllum also known as 'dabai' and this dabai fruit is eaten by the community in Sarawak. The fruit is a seasonal natural fruit that is less used because of its short lifespan. A few studies show that acetone extract of Canarium odontophyllum stem bark (dabai) exhibit antiproliferative and cytotoxicity effect on cancer colorectal cells. However, there is currently no analysis of bioactive compounds in acetone extract of Canarium odontophyllum stem bark (dabai). The various bioactive compounds detected in acetone extract were identified using gas chromatography-mass spectrometry (GC-MS). A total of 24 phytoconstituents were detected in this acetone extract. It was found that major peaks represented bicyclo [3.1.0] hex-2-ene,2-methyl-5-(1-methylethyl)-, bicyclo [3.1.0] hexane,4-methylene-1-(1-methylethyl)-, alpha cubebene, 1H cyclopenta [1,3] cyclopropa [1,2] benzene, octahydro-7-methyl-3-methylene-4-(1-methylethyl)-,[3aS-(3a.alpha., 3b.beta., 4.beta., 7.alpha., 7aS*)]-, phenol,2,4-bis(1,1-dimethylethyl)-, spathulenol, copaene, 9-Eicosene, (E)-, hexadecane, 5-Octadecene, (E)-, hexadecane, 2,6,10,14-tetramethyl-, nonadecane, n-Hexadecanoic acid, heptacosane, 1-chloro-, 9,12-Octadecadienoic acid (Z,Z)-, 9,12-Octadecadienoic acid, ethyl ester, octadecanoic acid, 10-Heneicosene (c,t), heptafluorobutyric acid, hexadecyl ester, dehydroabietic acid, phenol, 2,4-bis(1-phenylethyl)-, beta sitosterol, beta-amyrin and alpha-amyrin. The highest peak area (%) for this acetone extract is alpha-amyrin (16.6644%) followed by beta-amyrin (4.6159%), beta sitosterol (3.3369%) and 9,12-Octadecadienoic acid (Z,Z)- (3.2045%). In conclusion, various bioactive compounds detected in acetone extract of Canarium odontophyllum stem bark (dabai) were demonstrated various medicinal properties while alpha and beta-amyrin may be responsible for the cytotoxicity and apoptotic effect against HCT 116 cell.

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Synthesis and Evaluation of Cytotoxic Effects of Amino-ester Derivatives of Natural α,β-Amyrin Mixture

Cited by 4 publications

References 13 publications

Biotechnological potential of essential oils from different chemotypes of Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson

Biotechnological potential of essential oils from different chemotypes of Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson

ClTI, a Kunitz trypsin inhibitor purified from Cassia leiandra Benth. seeds, exerts a candidicidal effect on Candida albicans by inducing oxidative stress and necrosis

Analysis of GC-MS from Acetone Extract of Canarium odontophyllum Miq Stem Bark (Dabai)

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