Synthesis and Evaluation of Magnetic Nanoparticles for Biomedical Applications

Abstract

In this study, iron oxide (IO) nanoparticles from various precursors have been synthesized using sonochemical method and characterized for their structural variability and toxicity. e iron oxide (IO) precursor solutions were prepared from iron acetate (IA), iron pentacarbonyl (IP), decalin, PEG (poly(ethylene glycol)), EG (ethylene glycol), PVA (poly(vinyl alcohol)), -cyclodextrin (CD), and distilled water. ese precursor solutions were irradiated with high power ultrasound for 3 hours and heat treated as needed. ese as-prepared iron oxide nanoparticles were characterized using X-ray diffraction (XRD), Mössbauer spectroscopy, transmission electron microscopy (TEM), and magnetization measurements. XRD results show that all the particles are highly crystalline in nature and the particles sizes measured from TEM are approximately 5-20 nm. e maximum magnetization was observed for IO-IP at approximately 60.17 emu/g and the minimum was approximately 30.56 emu/g for IO-IA. ese results con�rm that the particles are superparamagnetic (SPM) in nature. Mössbauer spectroscopy veri�ed the magnetic nanoparticles are purely Fe 3 O 4 and particles sizes varied by the nature of the precursor and coatings.

Key Parameters for Scaling up the Synthesis of Magnetite Nanoparticles in Organic Media: Stirring Rate and Growth Kinetic

“…It is well known that uniform and well-defined NPs are required for biomedical applications to avoid the use of large doses or the manifestation of secondary effects after intravenous injection. 33…”

“…These variables at an industrial production level can be controlled and could be used to generate the desired particle size for a specific application. It is well known that uniform and well-defined NPs are required for biomedical applications to avoid the use of large doses or the manifestation of secondary effects after intravenous injection …”

Diazo transfer at polydopamine – a new way to functionalization

“…4 They have been widely used in medicine, 5 as drug delivery systems, 6,7 resonance imaging, 8 and as support for metal catalysts and organocatalysts. [9][10][11] Different coating agents have been used for covering MNP, 12,13 for example polymers like dextrane, 14 polyvinyl alcohol, 15 polypyrrole, 16 polyacrylates 17 and others. 18 Non-polymeric agents like carboxylic acids are also suitable.…”