SYNTHESIS AND EVALUATION OF NEW IMIDAZO[2,1-b]THIAZOLES AS ANTITUBERCULOSIS AGENTS

Ulusoy, Nuray; Gürsoy, Elif

doi:10.12991/marupj.259887

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…Imidazothiazole derivatives have attracted much attention in the last decade and might become potential therapeutic drugs. Ulusoy and Gürsoy synthesized a class of imidazothiazole derivatives, and the BACTEC460 radiation measurement system was used to evaluate the in vitro anti-mycobacterial activity of the synthesized compounds against Mycobacterium tuberculosis H 37 R V [ 40 ]. These compounds showed different degrees of inhibition in in vitro screening at the same concentration, while compound 13 ( Figure 7 A) had the best in vitro activity, with a MIC of 6.25 μg·mL −1 .…”

Section: Bench Study: Exploration Of the Pharmacological Activity Of ...mentioning

confidence: 99%

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From Bench to Bedside: What Do We Know about Imidazothiazole Derivatives So Far?

Guo

Zhu

et al. 2023

Molecules

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Imidazothiazole derivatives are becoming increasingly important in therapeutic use due to their outstanding physiological activities. Recently, applying imidazothiazole as the core, researchers have synthesized a series of derivatives with biological effects such as antitumor, anti-infection, anti-inflammatory and antioxidant effects. In this review, we summarize the main pharmacological effects and pharmacological mechanisms of imidazothiazole derivates; the contents summarized herein are intended to advance the research and rational development of imidazothiazole-based drugs in the future.

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Section: Bench Study: Exploration Of the Pharmacological Activity Of ...mentioning

confidence: 99%

“…Lung cancer [27,28] Melanoma [29,30] Breast cancer [31,32] Other cancer [33,34] Anti-infection Virus [35][36][37][38][39] Bacteria [2,[40][41][42][43] Parasite [44,45] Anti-inflammatory…”

Section: Antitumormentioning

confidence: 99%

From Bench to Bedside: What Do We Know about Imidazothiazole Derivatives So Far?

Guo

Zhu

et al. 2023

Molecules

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Biological Applications of Imidazothiazole Scaffolds: A Current Review

et al. 2022

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Due to the broad-spectrum biological activities, fused heterocyclic compounds are one of the most important systems in medicinal chemistry. Among them, the imidazothiazole which contains a bridgehead nitrogen atom has a vital role because of various applications such as anticancer, antimalarial, antiviral, etc. Designing various imidazothiazole scaffolds has become more important because of their several biological applications. The present review paper discusses the numerous biological applications of imidazothiazole scaffolds in the field of medicine. The review would be useful in future drug design for the development of more promising drug-like scaffolds.

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Biological Relevance of Five Membered Fused Heterocycle Imidazothiazole

Chandrashekharappa,

Barick,

Dhara

2024

Advances in Bioinformatics and Biomedical Engineering

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Heterocyclic compounds are essential in the metabolism of all living cells, and most nitrogen-containing fused heterocyclic compounds with five-membered rings are biologically active. Nitrogen and sulphur-containing heteroaromatic compounds, such as imidazothiazoles and their derivatives, are acknowledged for their biological activity and substantial contributions to medicinal chemistry. Imidazothiazoles are defined by their fused bicyclic structure, merging an imidazole ring (a five-membered ring with two non-adjacent nitrogen atoms) with a thiazole ring (a five-membered ring containing both sulphur and nitrogen atoms). This distinctive structure plays a crucial role in their biological activities and chemical stability. Imidazothiazoles display a wide range of biological activities, encompassing antimicrobial, antiviral, antifungal, anticancer, and anti-inflammatory properties.

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SYNTHESIS AND EVALUATION OF NEW IMIDAZO[2,1-b]THIAZOLES AS ANTITUBERCULOSIS AGENTS

Cited by 3 publications

References 23 publications

From Bench to Bedside: What Do We Know about Imidazothiazole Derivatives So Far?

From Bench to Bedside: What Do We Know about Imidazothiazole Derivatives So Far?

Biological Applications of Imidazothiazole Scaffolds: A Current Review

Biological Relevance of Five Membered Fused Heterocycle Imidazothiazole

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