Synthesis and evaluation of novel O-functionalized aminated chitosan derivatives as antibacterial, antioxidant and anticorrosion for 316L stainless steel in simulated body fluid

Hassan, Nazly; Hendy, Aisha; Ebrahim, Asmaa; Tamer, T.M.

doi:10.1016/j.jscs.2021.101368

Cited by 7 publications

(5 citation statements)

References 51 publications

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“…The maximal radical scavenging of 46% was accomplished by the ZnO (0.1%)@Am-CS bio-nanocomposite sample, compared to 29% for the native Am-CS membrane sample. The increase in the antioxidant action could be described by the incidence of more electron-donating atoms (i.e., nitrogen and oxygen) in the membrane matrix, which boost its ability to scavenge ABTS •+ radicals [52]. In addition, ZnONPs possess antioxidant potency via various mechanisms comprising free radical scavenging and reducing activities [53][54][55].…”

Section: Evaluation Of Antioxidant Activitymentioning

confidence: 99%

“…These results could be attributed to the biodegradation nature of the original Am-CS derivative [56]. The formulated bio-nanocomposite membranes have functional hydrophilic amino and hydroxyl groups, which have an affinity for lysozyme adsorption, while the glycosidic bonds would be hydrolyzed, initiating the degradation of the membrane constituents [46,52]. However, the biodegradation rate decreased slightly with the increasing ZnONP content in the membrane matrix.…”

Section: Evaluation Of In Vitro Biodegradabilitymentioning

confidence: 99%

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Fabrication of Antibacterial and Antioxidant ZnO-Impregnated Amine-Functionalized Chitosan Bio-Nanocomposite Membrane for Advanced Biomedical Applications

Ali,

Hamed,

Taher

et al. 2023

Molecules

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Developing a variety of safe and effective functioning wound dressings is a never-ending objective. Due to their exceptional antibacterial activity, biocompatibility, biodegradability, and healing-promoting properties, functionalized chitosan nanocomposites have attracted considerable attention in wound dressing applications. Herein, a novel bio-nanocomposite membrane with a variety of bio-characteristics was created through the incorporation of zinc oxide nanoparticles (ZnONPs) into amine-functionalized chitosan membrane (Am-CS). The developed ZnO@Am-CS bio-nanocomposite membrane was characterized by various analysis tools. Compared to pristine Am-CS, the developed ZnO@Am-CS membrane revealed higher water uptake and adequate mechanical properties. Moreover, increasing the ZnONP content from 0.025 to 0.1% had a positive impact on antibacterial activity against Gram-positive and Gram-negative bacteria. A maximum inhibition of 89.4% was recorded against Escherichia coli, with a maximum inhibition zone of 38 ± 0.17 mm, and was achieved by the ZnO (0.1%)@Am-CS membrane compared to 72.5% and 28 ± 0.23 mm achieved by the native Am-CS membrane. Furthermore, the bio-nanocomposite membrane demonstrated acceptable antioxidant activity, with a maximum radical scavenging value of 46%. In addition, the bio-nanocomposite membrane showed better biocompatibility and reliable biodegradability, while the cytotoxicity assessment emphasized its safety towards normal cells, with the cell viability reaching 95.7%, suggesting its potential use for advanced wound dressing applications.

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Section: Evaluation Of Antioxidant Activitymentioning

confidence: 99%

Section: Evaluation Of In Vitro Biodegradabilitymentioning

confidence: 99%

Fabrication of Antibacterial and Antioxidant ZnO-Impregnated Amine-Functionalized Chitosan Bio-Nanocomposite Membrane for Advanced Biomedical Applications

Ali,

Hamed,

Taher

et al. 2023

Molecules

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“…Despite the excellent chemical stability of the surface of a biomaterial, one way to improve it and increase its biocompatibility is through its surface modification. This can be achieved through the use of biopolymers [11][12][13][14] or bioceramics [13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

“…One of the natural biopolymers that has attracted the most attention is chitosan [11]. Chitosan is a linear polysaccharide of cationic nature with many properties such as being biocompatible, biodegradable, and non-toxic.…”

Section: Introductionmentioning

confidence: 99%

Electrophoretic Deposition of Chitosan–Hydroxyapatite Films and Their Electrochemical Behavior in Artificial Plasma

Mata-Davila,

Arrieta-Gonzalez,

Perez-Arizmendi

et al. 2023

Metals

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The electrochemical behavior of chitosan–hydroxyapatite films deposited on Ti CP was evaluated. Hydroxyapatite was synthesized from eggshell at different precipitation pH conditions. The films were deposited on the Ti CP surface from chitosan–hydroxyapatite solutions by means of electrophoretic deposition. The hydroxyapatite content of the solutions varied from 0 to 20 g/L. The different films obtained were evaluated by means of electrochemical measurements such as polarization curves, open circuit potential measurements, polarization resistance, and electrochemical impedance. The results obtained showed that regardless of the precipitation pH, it is possible to obtain pure hydroxyapatite from a waste such as eggshell. The incorporation of hydroxyapatite within the chitosan structure allows for improvement of the electrochemical performance of the bare Ti CP surface. It was observed that the passive zone was achieved at lower current densities, and that the stability zone of the passive layer increased. Electrochemical impedance analyzes showed that there is an improvement in corrosion resistance due to a more controlled growth of the passive layer that allows for the formation of a dense and compact film.

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“…In addition, β-(1-4) glycosidic linkages connect them. Chitosan has been shown to have various biological properties, including antibacterial [ 2 , 3 ], anticancer [ 4 ], antioxidant [ 5 ], hemostatic action [ 6 ], and drug delivery [ 7 ], as well as the ability to speed wound healing [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization, and Bio Evaluation of Fatty N- Hexadecanyl Chitosan Derivatives for Biomedical Applications

et al. 2022

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The objective of this study was to improve the antibacterial activities of chitosan via N-alkyl substitution using 1-bromohexadecane. Mono and di substitution (Mono-NHD-Ch and Di-NHD-Ch) were prepared and characterized using FT-IR, HNMR, TGA, DSC, and SEM. Elemental analysis shows an increase in the C/N ratio from 5.45 for chitosan to 8.63 for Mono-NHD-Ch and 10.46 for Di-NHD-Ch. The antibacterial properties were evaluated against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus cereus. In the examined microorganisms, the antibacterial properties of the novel alkyl derivatives increased substantially higher than chitosan. The minimum inhibitory concentration (MIC) of Mono-NHD-Ch and Di-NHD-Ch was perceived at 50 μg/mL against tested microorganisms, except for B. cereus. The MTT test was used to determine the cytotoxicity of the produced materials, which proved their safety to fibroblast cells. The findings suggest that the new N-Alkyl chitosan derivatives might be used as antibacterial alternatives to pure chitosan in wound infection treatments.

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Synthesis and evaluation of novel O-functionalized aminated chitosan derivatives as antibacterial, antioxidant and anticorrosion for 316L stainless steel in simulated body fluid

Cited by 7 publications

References 51 publications

Fabrication of Antibacterial and Antioxidant ZnO-Impregnated Amine-Functionalized Chitosan Bio-Nanocomposite Membrane for Advanced Biomedical Applications

Fabrication of Antibacterial and Antioxidant ZnO-Impregnated Amine-Functionalized Chitosan Bio-Nanocomposite Membrane for Advanced Biomedical Applications

Electrophoretic Deposition of Chitosan–Hydroxyapatite Films and Their Electrochemical Behavior in Artificial Plasma

Preparation, Characterization, and Bio Evaluation of Fatty N- Hexadecanyl Chitosan Derivatives for Biomedical Applications

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