Synthesis and evaluation of novel azoles as potent antifungal agents

Li, Liangjing; Ding, Hao; Wang, Baogang; Yu, Shichong; Zou, Yan; Chai, Xin‐Sheng; Wu, Qiuye

doi:10.1016/j.bmcl.2013.11.037

Cited by 26 publications

(12 citation statements)

References 13 publications

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“…Azoles bind with a nitrogen atom to the iron atom of the heme, preventing the demethylation of lanosterol [6]. The depletion of ergosterol and accumulation of 14a-methylated sterols disrupt the structure and many functions of fungal membrane leading to inhibition of fungal growth [7].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, biological evaluation and structure–activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors

Moraca

Vita

Pandolfi

et al. 2014

European Journal of Medicinal Chemistry

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Section: Introductionmentioning

confidence: 99%

Synthesis, biological evaluation and structure–activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors

Moraca

Vita

Pandolfi

et al. 2014

European Journal of Medicinal Chemistry

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“…In order to combat these infections, a number of antifungal agents are clinically available [195]. Emergence of resistance to the available drugs is a great encumbrance in the treatment of fungal infections and hence, development of new antifungal agents in a never ending task for chemists [196]. Over the time, numerous antifungal agents bearing piperazine have been developed by researchers (Figure 7).…”

Section: Antifungal Activitymentioning

confidence: 99%

Piperazine scaffold: A remarkable tool in generation of diverse pharmacological agents

Shaquiquzzaman

Verma

Marella

et al. 2015

European Journal of Medicinal Chemistry

198

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“…The high resistance to azoles that was observed is worrisome. Due to their broad spectrum of activity and safety profiles, azoles are the most commonly used antifungal drugs (Li et al, 2014).…”

Section: Antifungal Susceptibility Patternmentioning

confidence: 99%

Physico-chemical parameters and culturable yeast diversity in surface water: a consequence of pollution

Monapathi

Bezuidenhout

Rhode

2020

WSA

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Rivers in the North West Province (NWP) of South Africa are polluted by various anthropogenic activities that are associated with agricultural, domestic, industrial, and mining activities. Pollutants and effluent resulting from these activities impact the physico-chemical and biological characteristics of river water. More particularly, domestic and agricultural pollution has been associated with the occurrence of pathogenic yeast species in water. The aim of this study was to determine physico-chemical parameters, yeast levels, and the antifungal susceptibility of pathogenic yeasts in river water. Physico-chemical parameters and yeast levels were determined using standard procedures. Yeasts were identified by biochemical tests and 26S rRNA gene sequencing. Disc diffusion antifungal susceptibility tests were conducted on identified potential pathogenic yeasts. Physico-chemical parameters were within target water quality ranges (TWQR) for livestock farming but were mostly out of range for irrigation. Yeast levels (incubation at 37°C) ranged from 363 to 1 778 CFU/L. There were significant differences (p < 0.05) in the physico-chemical parameters and yeast levels between some seasons and among the river systems under study. A positive association was observed between temperature, COD and yeast levels in all the river systems. Ascomycetes, which were the most prevalent isolates, were identified as Candida spp. (35%), Pichia spp. (13%), Cyberlinera spp. (12%), Meyerozyma spp. (11%), Clavispora spp. (10%), Saccharomyces spp. (6%), Kluyveromyces spp. (5%), Yamadazyma spp. (4%), Trichosporon spp. (3%), and Wickerhamomyces spp. (1%). Antifungal resistance of the potential pathogenic yeasts was as follows: flucytosine and miconazole (100%) > fluconazole (78.5%) > econazole, and miconazole and ketoconazole (49.6%) > nystatin (15.2%). The river water systems explored in the study are used for agricultural, domestic and recreational purposes. Direct contact with the water, especially by immune-compromised people, may pose a health threat and should be further investigated.

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Synthesis and evaluation of novel azoles as potent antifungal agents

Cited by 26 publications

References 13 publications

Synthesis, biological evaluation and structure–activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors

Synthesis, biological evaluation and structure–activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors

Piperazine scaffold: A remarkable tool in generation of diverse pharmacological agents

Physico-chemical parameters and culturable yeast diversity in surface water: a consequence of pollution

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