Synthesis and Evaluation of Paclitaxel-Loaded Gold Nanoparticles for Tumor-Targeted Drug Delivery

Paciotti, Giulio F.; Zhao, Jielu; Cao, Shugeng; Brodie, Peggy J.; Tamarkin, Lawrence; Huhta, Marja S.; Myer, Lonnie D.; Friedman, Jay; Kingston, David G. I.

doi:10.1021/acs.bioconjchem.6b00405

Cited by 78 publications

(55 citation statements)

References 55 publications

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“…Devi et al have studied and characterized PTX‐polymeric nanoparticles by Fourier transform infrared (FT‐IR) and Raman spectroscopies . These spectroscopic analysis showed that the specific functional groups of the PTX‐polymeric nanoparticle have the same chemical characteristics than the pure paclitaxel drug, indicating that the molecular interaction with the NP surface does not affect the chemical structure of the drug . Contrary to this study, even if we have involved similar ingredients (drug, polymer) chelated to gold ions in order to form gold nanoparticles, the spectroscopical fingerprints of our final nanodrug are not peculiar compared to the free drugs.…”

Section: Resultsmentioning

confidence: 67%

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Taxanes Hybrid Nanovectors: From Design to Physico‐Chemical Evaluation of Docetaxel and Paclitaxel Gold (III)‐PEGylated Complex Nanocarriers

Marguerit

Moustaoui

Haddada

et al. 2017

Part & Part Syst Charact

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This study gives an original methodology to synthetize novel metallo‐drugs nanoparticles relevant for medicinal chemistry. Gold (HAuCl4) are complexes with antitumor compounds (paclitaxel (PTX); docetaxel (DTX)) and dicarboxylic acid‐terminated polyethylene‐glycol (PEG) that plays a role of surfactants. The proposed synthesis is fast and leads to hybrid‐metal nanoparticles (AuNPs) in which drug solubility is improved. The interactions between drugs (DTX, PTX), PEG diacid (PEG), and Au (III) ions to form hybrid nanocarriers called DTX IN PEG‐AuNPs and PTX IN PEG‐AuNPs, are characterized by various analytical techniques (Raman and UV–vis spectroscopies) and transmission electron microscopy. The efficient drugs release under pH conditions is also achieved and characterized showing an amazing reversible equilibrium between Au (III)‐complex‐drug and Au0NPs. For therapeutic purposes, such AuNPs are then decorated with the anti‐EGFR polyclonal antibodies, which specifically recognizes the hERG1 channel aberrantly expressed on the membrane of human lung cancer cells. This paper, through an original chemical approach, will occupy an important position in the field of nanomedicine, and hope that novel perspectives will be proposed for the development of high drug‐loading nanomedicines.

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Section: Resultsmentioning

confidence: 67%

“…DTX is more water soluble than PTX due to its chemical structure. [7b] In previous studies, DTX and PTX were derivatized at the hydroxyl group in the C‐2′ position to form a derivatized acid ester . The free hydroxyl group in this position is essential for anticancer activity .…”

Section: Resultsmentioning

confidence: 99%

Taxanes Hybrid Nanovectors: From Design to Physico‐Chemical Evaluation of Docetaxel and Paclitaxel Gold (III)‐PEGylated Complex Nanocarriers

Marguerit

Moustaoui

Haddada

et al. 2017

Part & Part Syst Charact

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“…[52]. The PTX-loaded redox-sensitive nanoparticles has shown greater in vitro cytotoxicity and apoptosis-inducing ability against CD44 over-expressed A549 tumor cells in comparison to the redox-insensitive nanoparticles [53]. In an in-vivo study, the PTX-loaded HSV nanoparticles exhibited an enhanced antitumor efficacy in a A549 mouse xenograft model [54].…”

Section: Lung Cancermentioning

confidence: 99%

Insights on Cancer Preventive Approaches Using Plant Based Extracts

Nair¹,

Bisht²,

Tk³

2018

Asian J Biomed Pharmaceut Sci

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Cancer is one of the fatal diseases, and it continues to pose a significant health problem worldwide. Although great efforts are being done to discover a cure, cancer still remains a very prominent cause of mortality in humans, and its effective treatment is a formidable challenge. Although cancer therapies have been performed throughout the history, the efficacy of the treatment still remains a challenge. In recent years, natural product compounds have become the first choice of treatment in many cases. Gene therapy, in addition, is offering selective new methods for treatment. This review emphasizes the advancements cancer treatment using naturally derived products with significantly less toxicity and more efficacies; thereby enhancing the understanding of different cancers and potential of the plant based extract in the anti-cancer field.

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“…[2][3][4][5][6][7][8] In this regard, gold nanoparticles are widely used in many research fields, including bio-sensin, [9][10][11] photothermal cancer therapy, 12,13 catalysis, 14,15 and drug delivery mechanisms. 16,17 Recently, two-dimensional (2D) triangular gold nanoplates (AuNPs) have been gaining considerable interest due to their unique optical properties and extremely high anisotropy. [18][19][20] 2D anisotropic AuNPs have large surface areas, sharp corners, and edges which can greatly enhance any applied electric fields.…”

Section: Introductionmentioning

confidence: 99%

Single-particle Correlation Study: Polarization-dependent Differential Interference Contrast Imaging of Two-dimensional Gold Nanoplates

Lee

2019

ANAL. SCI.

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Questions surrounding the optical properties of two-dimensional (2D) triangular single gold nanoplates (AuNPs) remain largely unanswered. Herein, a scanning-electron microscopy-correlated single-particle study was conducted to identify polarization-dependent optical properties of AuNPs under dark-field (DF) and differential interference contrast (DIC) microscopy. AuNPs with an aspect ratio of ∼3 showed a single broad DF scattering spectrum without separation of the two dipole and quadrupole resonance modes present in 2D AuNPs. Polarization-sensitive interference properties of the individual AuNPs were revealed through periodic changes in the intensities and types of DIC images obtained. A dipole resonance mode was found to mainly contribute to the polarization-sensitive interference properties of AuNPs. Furthermore, DIC polarization anisotropy allowed us to track the real-time orientation of a dipole resonance mode of a AuNP rotating on a live cell membrane.

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Synthesis and Evaluation of Paclitaxel-Loaded Gold Nanoparticles for Tumor-Targeted Drug Delivery

Cited by 78 publications

References 55 publications

Taxanes Hybrid Nanovectors: From Design to Physico‐Chemical Evaluation of Docetaxel and Paclitaxel Gold (III)‐PEGylated Complex Nanocarriers

Taxanes Hybrid Nanovectors: From Design to Physico‐Chemical Evaluation of Docetaxel and Paclitaxel Gold (III)‐PEGylated Complex Nanocarriers

Insights on Cancer Preventive Approaches Using Plant Based Extracts

Single-particle Correlation Study: Polarization-dependent Differential Interference Contrast Imaging of Two-dimensional Gold Nanoplates

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