Synthesis and Evaluation of Phenyliminoindolin-Containing Phenylacetamide Derivatives with the Antidepressant and Anticonvulsant Effects

Guan, Liping; Liu, Bingyu; Quan, Ying-Chun; Yang, Li‐Ye; Zhen, Xing-Hua; Wang, Sihong

doi:10.2174/1573406412666160201121456

Cited by 10 publications

(4 citation statements)

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“…Benzeneacetamide was also produced by S. omiyaensis SCH2 and S. pluripotens MUSC137 from mangrove sediments [18,44]. Previous studies reported that benzeneacetamide exhibited significant antibacterial, antidepressant and anticonvulsant effects [51][52]. In addition, natural deferoxamine was detected in the crude extracts of S. malaysiense MUSC 136 T and S. pluripotens MUSC137 isolated from mangrove soil samples [11,44].…”

Section: Discussionmentioning

confidence: 93%

Antibacterial, antioxidant, cytotoxic effects and GC-MS analysis of mangrove-derived Streptomyces achromogenes TCH4 extract

Tangjitjaroenkun

Pluempanupat

Tangchitcharoenkhul

et al. 2021

Arch biol sci (Beogr)

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The in vitro biological activities of the ethyl acetate extract of the culture filtrate from Streptomyces achromogenes TCH4 (TCH4 extract) were evaluated. The ethyl acetate extract of TCH4 produced a bacteriostatic effect against Enterobacter cloacae, Staphylococcus aureus, Staphylococcus saprophyticus, Bacillus subtilis, methicillin-resistant S. aureus (MRSA) and Klebsiella pneumoniae. The extract had bactericidal activity against S. aureus, S. saprophyticus, S. aureus (MRSA) and K. pneumoniae with minimum bactericidal concentration (MBC) values in the range of 500-1000 ?g/mL. The total phenolic and flavonoid contents in TCH4 were 107.20?2.57 mg gallic acid equivalent (GAE)/g and 44.91?0.84 mg quercetin equivalent (QE)/g of dry extract. Antioxidant activity was determined by DPPH radical (IC50 299.64?6.83 ?g/mL) and ABTS radical scavenging (IC50 65.53?0.95 ?g/mL), and the ferric-reducing antioxidant power (FRAP) (822.76?9.12 mM FeSO4.7H2O/g dry extract) assays. TCH4 exhibited cytotoxic activity in the DU-145 cell line (IC50 9.36?0.37 ?g/mL). Analysis of extract constituents by GC-MS revealed pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl) (36.85%), benzeneacetamide (23.76%), and deferoxamine (12.85%) as the major compounds, which have been reported to possess pharmaceutical properties. S. achromogenes TCH4 could be a potential source of bioactive metabolites with antibacterial, antioxidant and anticancer activities for pharmaceutical applications.

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Section: Discussionmentioning

confidence: 93%

Antibacterial, antioxidant, cytotoxic effects and GC-MS analysis of mangrove-derived Streptomyces achromogenes TCH4 extract

Tangjitjaroenkun

Pluempanupat

Tangchitcharoenkhul

et al. 2021

Arch biol sci (Beogr)

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“…( E,E )-2,4-Decadienal exhibited strong paralytic activity on second-stage Meloidogyne incognita, Meloidogyne javanica and Meloidogyne arenaria juveniles (Ntalli et al, 2016 ). Guan et al ( 2016 ) reported benzeneacetamide as an antidepressant-like and anticonvulsant compound. Phenolic compounds were alluded to as potent antimicrobial agents, as are free radical terminators, as they possess hydrogen-donating capability to reduce free radicals (Yogeswari et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Growth Promotion and Disease Suppression Ability of a Streptomyces sp. CB-75 from Banana Rhizosphere Soil

et al. 2018

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An actinomycete strain, CB-75, was isolated from the soil of a diseased banana plantation in Hainan, China. Based on phenotypic and molecular characteristics, and 99.93% sequence similarity with Streptomyces spectabilis NBRC 13424 (AB184393), the strain was identified as Streptomyces sp. This strain exhibited broad-spectrum antifungal activity against 11 plant pathogenic fungi. Type I polyketide synthase (PKS-I) and non-ribosomal peptide synthetase (NRPS) were detected, which were indicative of the antifungal compounds that Streptomyces sp. CB-75 could produce. An ethyl acetate extract from the strain exhibited the lowest minimum inhibitory concentration (MIC) against Colletotrichum musae (ATCC 96167) (0.78 μg/ml) and yielded the highest antifungal activity against Colletotrichum gloeosporioides (ATCC 16330) (50.0 μg/ml). Also, spore germination was significantly inhibited by the crude extract. After treatment with the crude extract of Streptomyces sp. CB-75 at the concentration 2 × MIC, the pathogenic fungi showed deformation, shrinkage, collapse, and tortuosity when observed by scanning electron microscopy (SEM). By gas chromatography-mass spectrometry (GC-MS) of the crude extract, 18 chemical constituents were identified; (Z)-13-docosenamide was the major constituent. Pot experiments showed that the incidence of banana seedlings was reduced after using Streptomyces sp. CB-75 treatment. The disease index was 10.23, and the prevention and control effect was 83.12%. Furthermore, Streptomyces sp. CB-75 had a growth-promoting effect on banana plants. The chlorophyll content showed 88.24% improvement, the leaf area, root length, root diameter, plant height, and stem showed 88.24, 90.49, 136.17, 61.78, and 50.98% improvement, respectively, and the shoot fresh weight, root fresh weight, shoot dry weight, and root dry weight showed 82.38, 72.01, 195.33, and 113.33% improvement, respectively, compared with treatment of fermentation broth without Streptomyces sp. CB-75. Thus, Streptomyces sp. CB-75 is an important microbial resource as a biological control against plant pathogenic fungi and for promoting banana growth.

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“…The goal of this study was to develop compounds that cure symptoms of depression while also preventing neurodegeneration, thereby con rming the validity of our medicinal design concept. In this report, we used a fusion technique to create effective multi-target ligands (MTDLs) [33][34][35] and combined this approach with previous research ndings [36][37][38][39], as shown in Fig. 1.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Activity Evaluation of Benzothiazole-Isoquinoline Derivatives

et al. 2022

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Synthesis and Evaluation of Phenyliminoindolin-Containing Phenylacetamide Derivatives with the Antidepressant and Anticonvulsant Effects

Cited by 10 publications

References 0 publications

Antibacterial, antioxidant, cytotoxic effects and GC-MS analysis of mangrove-derived Streptomyces achromogenes TCH4 extract

Antibacterial, antioxidant, cytotoxic effects and GC-MS analysis of mangrove-derived Streptomyces achromogenes TCH4 extract

Growth Promotion and Disease Suppression Ability of a Streptomyces sp. CB-75 from Banana Rhizosphere Soil

Synthesis and Biological Activity Evaluation of Benzothiazole-Isoquinoline Derivatives

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