Synthesis and evaluation of the cytotoxic and anti-proliferative properties of ZnO quantum dots against MCF-7 and MDA-MB-231 human breast cancer cells

Roshini, A. M. Sherene Christina; Jagadeesan, Srikanth; Cho, Young-Jae; Lim, Jong-Hwan; Choi, Kyung Hyun

doi:10.1016/j.msec.2017.08.014

Cited by 43 publications

(4 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, the cytotoxicity of ZnO QDs in HEK-293T cells was greater than in HeLa cells. However, Roshini et al reported that ZnO QDs showed less toxicity to HEK-293 cells but significantly induced cytotoxicity in human breast cancer cells (Roshini et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…ZnO NPs were reported to induce cytotoxicity in a variety of cancer cells, including HepG2, U87, MCF-7 etc. (Roshini et al, 2017). Moreover they can accumulate in various internal organs (such as liver, spleen, lungs, kidney, and heart) via circulation and then produce adverse consequences (Shen et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Commercially available cadmium-based QDs release toxic cadmium ions, which limit their future applicability, particularly in view of environmental regulations (Sudhagar et al, 2011;Aboulaich et al, 2012). ZnO QDs are promising and have received much attention because of their Cd-free, inexpensive, and excellent optical properties (Roshini et al, 2017). The widespread application inevitably cause the increased release into the environment.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

ZnO Quantum Dots Induced Oxidative Stress and Apoptosis in HeLa and HEK-293T Cell Lines

Yang

Song

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

Zinc oxide (ZnO) quantum dot (QD) is a promising inexpensive inorganic nanomaterials, of which potential toxic effects on biological systems and human health should be evaluated before biomedical application. In this study, the cytotoxicity of ZnO QDs was assessed using HeLa cervical cancer cell and HEK-293T human embryonic kidney cell lines. Cell viability was significantly decreased by treatment with 50 µg/ml ZnO QDs after only 6 h, and the cytotoxicity of ZnO QDs was higher in HEK-293T than in HeLa cells. ZnO QDs increased the level of reactive oxygen species and decreased the mitochondria membrane potential in a dose-dependent manner. Several gene expression involved in apoptosis was regulated by ZnO QDs, including bcl-2 gene and caspase. In HeLa cells, ZnO QDs significantly increased early and late apoptosis, but only late apoptosis was affected in HEK-293T cells. These findings will be helpful for future research and application of ZnO QDs in biomedicine.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

ZnO Quantum Dots Induced Oxidative Stress and Apoptosis in HeLa and HEK-293T Cell Lines

Yang

Song

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…1 ZnO QDs have drawn much attention because they are Cd-free, low cost, and have excellent optical properties. 2,3 They have been explored in biomedical applications, including fluorescent probes, clinical diagnostics, and drug delivery. 4 Their small size and high specific surface area make QDs more reactive, and more complex interaction with biological systems.…”

Section: Introductionmentioning

confidence: 99%

<p>Gene Expression Profiling of the Liver and Lung in Mice After Exposure to ZnO Quantum Dots</p>

Yang¹,

Li²,

Lin³

et al. 2020

IJN

View full text Add to dashboard Cite

Introduction: ZnO quantum dots (QDs) have drawn much attention recently as they are Cd-free, low-cost, and have excellent optical properties. With the expanded production and application of ZnO nanoparticles, concerns about their potential toxicity have also been raised. Materials and Methods: We used RNA sequencing (RNA-seq) to analyze the global gene expression of liver and lung tissues after ZnO QDs treatment. Differentially expressed genes (DEGs) were screened, with a fold change >1.5 and padj <0.05. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed, and padj <0.05 was considered significantly enriched. The RNA-seq results were validated by quantitative real-time polymerase chain reaction (qRT-PCR). Results: A total of 47 and 218 genes were significantly differentially expressed in the liver and lung. Eight GO terms were enriched in the liver and lung, and retinol metabolism and the peroxisome proliferator-activated receptor (PPAR) signaling pathway were shared in different tissues. Discussion: According to DEGs and pathway enrichment analyses, inflammation might be induced in liver and lung tissues after intravenous injection of ZnO QDs. These findings will be helpful for future research and application of ZnO QDs.

show abstract

Green Chemical Approach for the Synthesis of ZnO Nanoparticles and Investigation of their Cytotoxicity

Hamrayev,

Jazayeri,

Yusefi

et al. 2024

Part & Part Syst Charact

View full text Add to dashboard Cite

In this study, zinc oxide nanoparticles (ZnO‐NPs) are synthesized and combined with chitosan (Cs) to create Cs/ZnO‐NPs nanomicelles, aiming to investigate their potential as a novel cancer treatment. The ZnO‐NPs are produced through a sintering process at temperatures ranging from 300 to 700 °C. The most effective nanoparticles are obtained at 600 °C, as determined by X‐ray diffraction (XRD) and Fourier‐transform infrared spectroscopy (FTIR) analyses, which confirmed their crystallinity and purity. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) are employed to characterize the size and shape of the nanoparticles, revealing predominantly spherical and hexagonal structures with stable dimensions. The cytotoxic effects of the Cs/ZnO‐NPs are evaluated against various cancer cell types. The results show that at a concentration of 125 µg mL−1, the Cs/ZnO‐NPs demonstrate significantly higher cancer cell toxicity compared to ZnO‐NPs alone, while remaining non‐toxic to normal cells. This indicates that Cs/ZnO‐NPs have a superior ability to selectively target cancer cells. These findings suggest that Cs/ZnO‐NPs nanomicelles hold promise as an effective and safe nanotherapeutic approach in the realm of cancer treatment, meriting further exploration for clinical applications.

show abstract

Synthesis and evaluation of the cytotoxic and anti-proliferative properties of ZnO quantum dots against MCF-7 and MDA-MB-231 human breast cancer cells

Cited by 43 publications

References 45 publications

ZnO Quantum Dots Induced Oxidative Stress and Apoptosis in HeLa and HEK-293T Cell Lines

ZnO Quantum Dots Induced Oxidative Stress and Apoptosis in HeLa and HEK-293T Cell Lines

<p>Gene Expression Profiling of the Liver and Lung in Mice After Exposure to ZnO Quantum Dots</p>

Green Chemical Approach for the Synthesis of ZnO Nanoparticles and Investigation of their Cytotoxicity

Contact Info

Product

Resources

About