Synthesis and fungicidal activity of 2‐substituted‐3‐(4‐fluorophenyl)‐benzofuro [3,2‐d] pyrimidin‐4(3H)‐ones

Abstract

Carbodiimide, obtained from aza‐Wittig reaction of iminophosphorane with 4‐fluorophenyl isocyanate, reacted with various nucleophiles under mild conditions to give a series of 2‐substituted‐3‐(4‐fluorophenyl)‐benzofuro [3,2‐d] pyrimidin‐4(3H)‐ones in satisfactory yield. Their structures were confirmed using NMR, EI‐Ms, IR, and elementary analysis, and compound 7b was further analyzed by single‐crystal. The preliminary bioassays indicated that these compounds showed moderate fungicidal activities against six kinds of fungi at a concentration of 50 mg/L. J. Heterocyclic Chem., 2010.