Synthesis and Heme Polymerization Inhibitory Activity (HPIA) Assay of Antiplasmodium of (1)-N-(3,4-Dimethoxybenzyl)-1,10-Phenanthrolinium Bromide from Vanillin

Fitriastuti, Dhina; Mardjan, Muhammad Idham Darussalam; Jumina, Jumina; Mustofa, Mustofa

doi:10.22146/ijc.21260

Cited by 6 publications

(8 citation statements)

References 5 publications

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“…It is an amorphous powder with green colouration. Its melting point is higher than those of the ligands, this result showed confirmation with other research works [19,22,23]. The elemental analysis result of the complex correspond with the proposed formula: [Cu(SUF)(phen)(SCN)2].…”

Section: Mixed-ligand Metal Complexes Of Sulfamethazine With 1 10-phenanthrolinesupporting

confidence: 87%

“…One of the most interesting features of the drug -metal coordinated system is the concerted spatial arrangement of the drug (Ligands) around the metal ion [4,5,[17][18][19][20]. The properties of the complexes (both redox and photochemical) which are gradually varied leads to appropriate substitution on the phenanthroline rings [8,9,[22][23][24][25]. In this study, we present the spectroscopic analysis of the metal (II) complex of mixed Ligand Sulphamethazine mixed with 1,10 Phenanthroline.…”

Section: Introductionmentioning

confidence: 99%

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Spectroscopic Study of Metal (II) Complex of Sulphamethazine with 1,10 Phenanthroline

Enemose¹,

Nworu²,

Innocent³

et al. 2021

Acta Chemica Malaysia

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As part of the current research for more effective antimalarial drug, Cu (II) complex of sulphamethazine with 1,10 phenanthroline was synthesized. The novel complex was characterized by Elemental analysis, FT-IR and electronic spectroscopy. The novel complex is insoluble in water, which is an indication of covalent and non- electrolyte character. The elemental analysis result of the complex correspond with the proposed formula [Cu(SUF)(phen)(SCN)2]. The electronic spectrum of sulfamethazine and 1, 10- phen showed absorption bands at 212 nm (47169 cm−1) and 306 nm (32679 cm–1). These bands were assigned to the n – δ* and π – δ* transitions. The infrared bands were seen at 3443 – 3344 cm −1which were attributed to the presence of v(NH2), v(NH) and v (OH) vibrations experience bathochromic shift in the metal complex. The parent ligands acted as a bidentate chelating agent showing coordination through the pyridine nitrogen and the nitrogen of the NH moiety in this case.

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Section: Mixed-ligand Metal Complexes Of Sulfamethazine With 1 10-phenanthrolinesupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Spectroscopic Study of Metal (II) Complex of Sulphamethazine with 1,10 Phenanthroline

Enemose¹,

Nworu²,

Innocent³

et al. 2021

Acta Chemica Malaysia

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“…In this report, we have prepared 1-(2-methoxybenzyl)-1,10-phenanthrolin-1-ium bromide from readily available starting materials via simple synthetic methods. The new compound may contribute to the construction of our small library of 1-(N)-substituted-1,10phenanthrolinium salts [7][8][9][10][11][12] and were expected to have biological activities. From a synthetic point of view, 1-(2-methoxybenzyl)-1,10-phenanthrolin-1-ium bromide can be simply disconnected to give benzyl halides and 1,10-phenanthroline via bimolecular nucleophilic substitution.…”

Section: Resultsmentioning

confidence: 99%

“…In the connection to the pharmaceutical applications, our group have prepared a small library of 1-(N)-substituted-1,10-phenanthrolinium salts [7][8][9][10][11][12]. These compounds were then subjected to in vitro and in vivo anti plasmodium assay against two strains of Plasmodium falciparum of FCR3 (resistance to chloroquine) and D10 (sensitive to chloroquine) [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 1-(2-Methoxybenzyl)-1,10-phenanthrolin-1-ium Bromide from Gandapura Oil

Mardjan

Fitriastuti

Purwono

et al. 2019

J. Pure App. Chem Res

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This study describes simple synthetic method to prepare 1-(2-methoxybenzyl)-1,10-phenanthrolin-1-ium bromide from gandapura oil. The salt were synthesized in four steps. Initially, commercial gandapura oil was directly subjected to the alkylation reaction under basic condition using dimethyl sulfate to give methyl 2-methxybenzoate in 86% yield. Next, the produced benzoate ester was reduced by LiAlH4 to produce 2-methoxybenzyl alcohol in 67% yield. The treatment of benzyl alcohol with phosphorus tribromide under solvent free condition produced the corresponding benzyl bromide (in 67% yield), which was directly introduced into bimolecular nucleophilic substitution reaction with 1,10-phenantroline monohydrate to finally give the desired product in 63% yield.

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“…Then shaking it until dissolved and added with another 0.2 M NaOH solution to a volume of 12 mL. [ 15 ] method with related modifications to the concentration of the λ solution and the test material [16]. 100 pL of 1 mM haematin solution in 0.1 M NaOH was put into the Eppendorf tube, then added 50 pL of test material with various levels of levels, namely 1.25 ; 0.625 ; 0.312 ; 0.156 ; and 0.078 mg / mL.…”

Section: Preparation Of 1 MM Haematin Solutionmentioning

confidence: 99%

Antimalarial Activity of Sea Sponge Extract of Stylissa massa originating from waters of Rote Island

et al. 2021

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Research on the isolation, toxicity test, antimalarial test, and identification of the active compound from the ethyl acetate fraction of Stylissa massa sponge from Oenggae waters, Rote Island, has been conducted. This study aimed to investigate the antimalarial activity of the ethyl acetate fraction of the Stylissa massa sponge. Isolation was carried out by the extraction method using a mixed solvent of methanol: dichloromethane of 3: 2 (v/v), then the extract was partitioned in a solvent mixture of ethyl acetate: water of 1: 2 (v/v). The ethyl acetate extract obtained was separated by column chromatography using the gradient polarity system method. The toxicity test of each fraction was carried out by the Brine Shrimp Lethality Test (BSLT) method, and the antimalarial test was carried out by the haematin polymerization inhibition method. Identification of compounds from the active fraction in the antimalarial test was carried out using Liquid Chromatography-Mass Spectrometry (LC-MS). The extraction yield was 1.14 g (0.23%) of the ethyl acetate extract in the form of a dark brownish-yellow oily solid. Separation by column chromatography resulted in 15 fractions. Toxicity test results showed the four most active fractions with LC50 values, which are very promising for new drug discovery. The IC50 value in the antimalarial activity test of the four fractions indicated that the Stylissa massa sponge ethyl acetate extract was more active than the standard chloroquine compound (115 μg/mL). The LC-MS analysis indicates that fraction 11 contains two compounds that have been reported, and 1 compound is unknown. In contrast, fraction 14 indicates that it contains three compounds that have been reported and one unknown compound.

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Synthesis and Heme Polymerization Inhibitory Activity (HPIA) Assay of Antiplasmodium of (1)-N-(3,4-Dimethoxybenzyl)-1,10-Phenanthrolinium Bromide from Vanillin

Cited by 6 publications

References 5 publications

Spectroscopic Study of Metal (II) Complex of Sulphamethazine with 1,10 Phenanthroline

Spectroscopic Study of Metal (II) Complex of Sulphamethazine with 1,10 Phenanthroline

Synthesis of 1-(2-Methoxybenzyl)-1,10-phenanthrolin-1-ium Bromide from Gandapura Oil

Antimalarial Activity of Sea Sponge Extract of Stylissa massa originating from waters of Rote Island

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