Synthesis and Hemostatic, Anti-Inflammatory, and Anthelminthic Activity of 2-hydroxy-4-oxo-4-(thien-2-yl)but-2-enoic Acid Derivatives

Synthesis, recyclization under the action of methanol and analgetic activity of N'-(5-aryl-2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides

“…Such a universal structural fragment can be found among the 3-imino-(hydrazinylidene)-furan-2(3H)-one derivatives, which results from their chemical availability due to the scalability of the synthetic methods [8] and the reactivity [9][10][11][12][13][14][15]. For example, the reactions of 3-imino-(hydrazinylidene)-furan-2(3H)-ones derivatives with various nucleophilic reagents lead to the attack on the carbonyl group of the lactone fragment and to the for-mation of acyclic or heterocyclic structures [16][17][18][19][20][21] that retain the pharmacophore fragment of 2,4-dioxobutanoic acid [22][23][24][25][26][27][28][29][30][31][32]. This fragment was found in the structure of various biologically active and natural compounds [33,34], which indicates that this idea is worth developing.…”

Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids

“…Derivatives of 3-imino-and 3-hydrazonofuran-2(3H)one are excellent for this role because of their chemical availability, scalability of synthetic methods [8][9][10][11][12] and high reactivity [13][14][15][16][17]. Derivatives of 3-imino-and 3-hydrazonofuran-2(3H)-ones are capable of interacting with various nucleophilic reagents to form acyclic structures preserving the pharmacophore fragment of 2,4-dioxobutanoic acid [18][19][20][21][22][23][24][25][26][27].…”