Synthesis and in‐vivo taste assessment of meloxicam pivalate

Strategies for Taste Masking of Orodispersible Dosage Forms: Time, Concentration, and Perception

“…In addition, chemical modifications to the API influence the aftertaste of prodrugs, which needs to be evaluated. At present, primary drugs to improve taste with the help of prodrugs include antibiotics erythromycin and its derivatives, , norfloxacin; opioid analgesics nalbuphine, naloxone, and naltrexone; pain killer drug paracetamol; and anti-inflammatory drug meloxicam . In general, the taste-masking effect of the prodrugs is stable without additional excipients; however, the lack of unified design of prodrugs results in tedious and difficult preparation, repeated tests and high cost.…”

Visible-light-induced C–S bond formation in the synthesis of 2,4-disubstituted thiazoles through cascade difunctionalization of acetophenone: a greener approach

“…These compounds have demonstrated potent and noteworthy biological effects 14,15 similar to various existing drugs with well-established uses. For instance, they exhibit properties akin to anti-inflammatory drugs like meloxicam, 16 anticancer drugs like dasatinib, 17,18 antiparasitic drugs like nitazoxanide, 19 pesticide drugs like thiabendazole, 20 antimicrobial drugs like sulfathiazole, 21 antifungal drugs like abafungin, 22,23 antineoplastic drugs like guineamide, 24,25 broad-spectrum third-generation cephalosporin antibiotics, 26 anti-bacterial drugs like cefotaxime, inhibitors like fatostatin, vitamin B 1 , thiamine, and antiulcerogenic drugs like famotidine. 27 Consequently, thiazole derivatives warrant thorough biological investigations to assess their potential applications in various pharmacological fields 28 (Fig.…”

Bromine‐Mediated C‐S Bond Formation: Synthesis of Thiazoles from α‐Methylene Ketones by Using Oxone Oxidative System

“…The thiazole structures, a special kind of five membered heterocyclic rings containing both sulfur and nitrogen, are found in many powerful drug skeletons such as anti-inflammatory drug Meloxicam [1] , anticancer drug Dasatinib [2] , anticonvulsant drugs [3] , antiparasitic drug Nitazoxanide [4] , and pesticide drug Thiabendazole [5] . Thus, this imperative ring framework keeps on pulling in consideration from the medicinal chemists and new synthetic way for thiazole rings keeps on being explored.…”