Synthesis and in vitro antitrypanosomal activity of novel Nifurtimox analogues

Characterization of electronic structure and physicochemical properties of antiparasitic nifurtimox analogues: A theoretical study

“…The antitrypanocidal activity has been recently reported as percentage of growth inhibition [16] which is reported in Table I. It is worth mentioning that the activity observed for all the analogues is in complete agreement with our theoretical results since molecules in groups I and II present larger activity than those in group IV.…”

“…they are 5-nitrofurans. In contrast, molecules in group IV such as NTH and NFH, lack a nitro moiety, and show a drastic decrease of the trypanocidal response [16]. It is important to mention that notwithstanding that the relative scale of activity is present; we want to focus the discussion on the particular features of the molecules in terms of the groups they pertain and the trends of the analyzed properties that we found, instead of comparing our results with the activities.…”

“…The antitrypanocidal activity has been recently reported as percentage of growth inhibition [16], see Table I, with the following activity scale: NFP Ͼ NFI ϭ NFN Ͼ NFC Ͼ NTN Ͼ NBT Ͼ NTH Ͼ NFH, in a decreasing order. Hence, the most potent derivatives such as NFP, NFI, NFN, and NFC belong to groups I and II, i.e.…”

“…We have performed an ab initio study at the Hartree-Fock and DFT levels of theory for several NFX analogues recently synthesized [16] to characterize them by obtaining their electronic, structural, and physicochemical properties, which might be linked to the observed antichagasic activity. The antitrypanocidal activity has been recently reported as percentage of growth inhibition [16] which is reported in Table I.…”

Trypanocidal tetrahydrofuran lignans from Peperomia blanda

“…Chagas disease is one of the most widespread of tropical diseases, being endemic in 21 countries, with some 16-18 million individuals infected and a further 100 million people at risk (Molfetta et al, 2005;Pozas et al, 2005).…”