“…NBS, CCl 4 , 62%; b. NaH, KI, DMF, 80%; c. TBAF, THF, 88%; d. N-phthaloyl 1-amino-4-pentyne, 29 Pd(PPh 3 ) 4 , pyrrolidine, 42%; e. H 2 NNH 2 -H 2 O, EtOH,; then N-Boc-Gln, HATU, DIPEA, DMF, 21%; then 4M HCl in dioxane, 97%; f) Pd(PPh 3 ) 4 , pyrrolidine, 80°C, 42%; then 4N HCl in dioxane, 51%; g) 5-chloro-1-pentyne, K 2 CO 3 , DMF, 97%; then LiOH-H 2 O, MeOH-THF, 99%.…”