Synthesis and Inhibitory Activity of Novel Tri- and Tetracyclic Quinolines against Topoisomerases

Methods for the construction of [1,2]isoindolo-condensed benzazepines, benzazocines, quinolines, and isoquinolines. 2. Isoindoloquinolines, isoindoloisoquinolines. (Review)

“…Later [2,6,7] attempts were made to modify the conditions for the cyclization of various N-(2-acetylaryl)phthalimides in order to optimize the yield of the required isoindolo[2,1-a]quinolines. Thus, the isoindolo[2,1-a]quinolines 23a-g are formed when the substituted 2-aminoacetophenones 19a,b and substituted phthalic anhydrides 20a-e are boiled in xylene in the presence of a base [2].…”

“…Thus, the isoindolo[2,1-a]quinolines 23a-g are formed when the substituted 2-aminoacetophenones 19a,b and substituted phthalic anhydrides 20a-e are boiled in xylene in the presence of a base [2]. The initial methoxyacetanilides 19 are obtained by the regiospecific acylation of the corresponding aromatic amines with methoxyacetonitrile (catalyst BCl 3 ).…”

Facile Access to Benzothiazole‐Containing Pyrrolo[1,2‐a]quinolines and Pyrrolo[2,1‐a]isoquinolines via Nitrogen Ylides

“…[1][2][3][4][5][6][7] On the other hand, pyrrolo [1,2-a]quinolines are reported as tumor inhibitors 8,9 and pyrrolo[2,1-a]isoquinolines have also been found to exhibit a broad spectrum of biological activities. [10][11][12][13] In addition, benzothiazoles are highly versatile chemicals which exhibit a wide spectrum of use in pharmaceutical and industrial areas.…”

Intramolecular [4+2] cycloaddition of furfurylsubstituted homoallylamines to allylhalides, acryloyl chloride and maleic anhydride

“…First it was interesting to investigate the competing intramolecular cycloaddition processes in the case of amines 4 and 5 possessing several potential diene and/or dienophilic centers. The second aim was to synthesize a series of carboxyl non substituted isoindolo [2,1-a]quinolines 2 (-benzazepines 3) as their further functionalization could allow us to find some perspective ways for the construction of the patented pharmacophores analogues [9][10][11][12][13][14].…”