Synthesis and Investigation of Antidiabetic Response of New Coumarin Derivatives Against Streptozotocin Induced Diabetes in Experimental Rats

Gupta, Mandeep Kumar; Kumar, Singh Anil; Chaudhary, Sachin

doi:10.1007/s11094-020-02134-w

Cited by 7 publications

(1 citation statement)

References 22 publications

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“…In vivo studies against streptozotocin (STZ)-induced diabetes in rats have been performed with a series of 3-phenylcoumarins substituted at position 7 by a complex ether chain. Several compounds proved to have a good profile, with compound 76 (Figure 23) being the most interesting, comparable with glibenclamide (IC 50 = 0.22 µM, MDR1) [162].…”

Section: Global Pharmacological Effectsmentioning

confidence: 99%

3-Phenylcoumarins as a Privileged Scaffold in Medicinal Chemistry: The Landmarks of the Past Decade

2021

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3-Phenylcoumarins are a family of heterocyclic molecules that are widely used in both organic and medicinal chemistry. In this overview, research on this scaffold, since 2010, is included and discussed, focusing on aspects related to its natural origin, synthetic procedures and pharmacological applications. This review paper is based on the most relevant literature related to the role of 3-phenylcoumarins in the design of new drug candidates. The references presented in this review have been collected from multiple electronic databases, including SciFinder, Pubmed and Mendeley.

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Section: Global Pharmacological Effectsmentioning

confidence: 99%

3-Phenylcoumarins as a Privileged Scaffold in Medicinal Chemistry: The Landmarks of the Past Decade

2021

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Synthesis and Biological Properties of Coumarin Derivatives. A Review

et al. 2021

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Coumarin and its derivatives are widely used as scaffolds in the synthesis of new heterocyclic systems. This review focuses on current developments in the synthesis of heterocyclic coumarin compounds. Numerous approaches especially involving nanoparticle catalysts have been developed to get new bioactive coumarin derivatives endowed with pharmacological and biological activities. The present work describes the reactivity and the new strategies using various catalysts for the synthesis of coumarin and its derivatives reported in the literature and their biological properties.

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Sugar Functionalized Coumarin Motifs: Synthesis and Applications

Dwivedi,

Dey,

2024

Carbohydrate Research

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Synthesis and Investigation of Antidiabetic Response of New Coumarin Derivatives Against Streptozotocin Induced Diabetes in Experimental Rats

Cited by 7 publications

References 22 publications

3-Phenylcoumarins as a Privileged Scaffold in Medicinal Chemistry: The Landmarks of the Past Decade

3-Phenylcoumarins as a Privileged Scaffold in Medicinal Chemistry: The Landmarks of the Past Decade

Synthesis and Biological Properties of Coumarin Derivatives. A Review

Sugar Functionalized Coumarin Motifs: Synthesis and Applications

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