Synthesis and investigation of the effect of piperazinylcholine amidophosphates on blockage of serotonin uptake

Structural and biological survey of 7‐chloro‐4‐(piperazin‐1‐yl)quinoline and its derivatives

“…In 1992, Sidorin et al discussed the ability of 7‐chloro‐4‐(piperazin‐1‐yl)quinoline ( 1 ) and its amidophosphate derivative ( 65 ) to inhibit the serotonin uptake (IC 50 : 50 and 40 μM, respectively) (Sidorin, Kozyukov, Zakharova, Porodenko, & Krukov, 1992). In 2014, Spadoni et al identified through docking studies compound 66 as a hybrid structure from 7‐chloro‐4‐(piperazin‐1‐yl)quinoline and serotonin like as 5‐HT7 antagonists that can bind at two different pockets of 5‐HT 7 the binding sites (Spadoni et al, 2014; Figure 9).…”