Synthesis and <i>In Vitro </i> Antimicrobial Activity of 3-(5-((2-Oxo-2<i>H</i>-Chromen-4-yl)Thio)-4-Phenyl-Thiazol-2-yl)-2-Substitutedphenyl Thiazolidin-4-One

Abstract

An array of 3-(5-((2-oxo-2H-chromen-4-yl) thio)-4-phenyl thiazol-2-yl)-2-substitutedphenyl thiazolidin-4-one (7a-j) have been synthesized by using acetophenone, thiourea, 4-mercaptocoumarin and thioglycolic acid. The structures of these compounds were confirmed by IR, 1H NMR, 13C NMR and mass analysis. All the newly synthesized derivatives were evaluated for their in vitro antibacterial activity (against E.coli,P.aeruginosa,S.aureus, S. pyogenes) and antifungal activity against (C. albicans, A.niger, A.clavatus) using broth dilution technique. Some of the compounds showed good to moderate activity against the specific microbial strain.