Synthesis and micellization of a multi-stimuli responsive block copolymer based on spiropyran

Abstract

A pH-, light-, LCST- and UCST-responsive block copolymer based on spiropyran is synthesized and the modulated micellization is demonstrated.

Multiresponsive Poly(N-Acryloyl glycine)-Based Nanocomposite and Its Drug Release Characteristics

“…PNAG also showed thermoresponsive properties when its environmental temperature changed due to Hbonding of amide bonds in the chains with water molecules [31,32], similarly to the case of the amino acid-derived polymers, such as poly(N-acryloyl glycinamide) (PNAGA) [33], poly(acrylamide) (PAAm), and poly(acrylic acid) (PAA) [34][35][36]. However, the study in upper critical solution temperature (UCST) of PNAG homopolymer has never been reported, while that of PNAG-containing copolymer was very limited [37]. At the temperature below the UCST, PNAG should be stabilized by intramolecular H-bonding, resulting in the formation of solid hydrogels.…”

UV‐triggered CO2‐responsive behavior of nanofibers and their controlled drug release properties

“…The advantage of this method is that it can effectively suppress a burst release and unexpected drug release from CDRSs at the beginning once brought into contact with the release medium . Moreover, double or multiresponsive drug carriers can adjust their amount of drug release by various stimulation methods . For instance, Theato and coworkers prepared a CO 2 ‐triggered temperature‐responsive behavior of vesicles for the controlled release of Nile red as a model system.…”

“…37 Moreover, double or multiresponsive drug carriers can adjust their amount of drug release by various stimulation methods. 38,39 For instance, Theato and coworkers 33 prepared a CO 2 -triggered temperature-responsive behavior of vesicles for the controlled release of Nile red as a model system. In the absence of CO 2 , Nile red cannot be released at various temperatures.…”

Poly(ethylene glycol) brush-b-poly(N-vinylpyrrolidone)-based double hydrophilic block copolymer particles crosslinked via crystalline α-cyclodextrin domains

“…13 Another option is to utilize a double hydrophilic block copolymer (DHBC) that features a stimuli responsive block. Such a stimuli responsive block is capable of switching from hydrophilic to hydrophobic upon application of heat, 14,15 pH change 16,17 or redox reactions 18,19 to facilitate a self-assembly process. In this case the self-assembly is rather driven via hydrophobicity induced aggregation.…”