UV‐triggered CO₂‐responsive behavior of nanofibers and their controlled drug release properties

Abstract

A novel nanofibrous mat featuring an ultraviolet (UV)-induced CO 2 -responsive behavior was fabricated via electrospinning and used as a controlled drug release system. First, a random copolymer for electrospinning, poly(N,N-diethybenzophenone) [P(DEEA-co-BA-co-DMNOBA-co-ABP)], was prepared based on pentafluorophenyl esters via an "active ester-amine" chemistry reaction. Subsequently, doxorubicin hydrochloride (DOX)-loaded P(DEEA-co-BA-co-DMNOBA-co-ABP) nanofibers were fabricated, yielding a new drug-loaded nanofibrous mat as a potential wound dressing. These DOX-loaded nanofibers can respond to UV irradiation and CO 2 stimulation. Interestingly, without UV irradiation, the fabricated nanofibers cannot exhibit any responsiveness. Therefore, the majority of the DOX was steadily stored in the nanofibers, even in the presence of CO 2 . However, upon UV irradiation, the CO 2 -responsive behavior of the nanofibers was activated and the prepared nanofibers swelled slightly, resulting in the release of around 42% DOX from the nanofibers. Upon further purging with CO 2 , the release amount of DOX from the nanofibers could reach up to approximately 85%, followed by the morphological transition from a nanofibrous mat to a porous hydrogel film.

Magnetically Actuated Drug Delivery Helical Microrobot with Magnetic Nanoparticle Retrieval Ability

“…This is because the UV method is capable of chemical and biological reactions and drug release through chemical reactions can be expected from the drug delivery microrobot. However, its applicable range is very narrow because of the very small penetration skin depth of several tens of micrometers and causes several problems, such as erythema, pigmentation, and DNA destruction. ,− …”

Upconversion Nanoparticle-Based Cell Membrane-Coated cRGD Peptide Bioorthogonally Labeled Nanoplatform for Glioblastoma Treatment

“…In this project, we introduced a bioorthogonal click reaction between nopoldiol and ortho-substituted arylboronic acids to label the ROS-cleavable PEGylated cRGD ligand on the U87 cell membrane. Light-triggered drug release has been reported previously. , Radiation within the ultraviolet (UV), visible, and NIR regions can stimulate drug release in vivo . − However, a wavelength below 650 nm impossibly penetrates deeper than 1 cm into tissue because of high scattering and absorption in vivo . NIR light of 650–1000 nm can go deeper (up to 10 cm) into living tissue and cause negligible tissue damage at the site of application .…”

A Bioinspired Hierarchical Underwater Superoleophobic Surface with Reversible pH Response

“…[ 55–57 ] In previous studies, we presented that polymers decorated with pentafluorophenyl (PFP) esters are promising active precursors for a post‐polymerization modification, because they can react with amines under very mild reaction conditions yielding functionalized polymer architectures, which would not be accessible otherwise. [ 58,59 ] Thus, we are particularly interested in constructing smart surfaces via an AAO template method combining with a post‐polymerization modification strategy under mild condition. In this work, active ester bearing poly(pentafluorophenyl acrylate) (PPFPA) micropillars are fabricated by in situ polymerization inside a porous AAO template onto a poly(ethylene terephthalate) (PET) film substrate.…”