Upconversion Nanoparticle-Based Cell Membrane-Coated cRGD Peptide Bioorthogonally Labeled Nanoplatform for Glioblastoma Treatment

Mo, Jingxin; Chen, Xianjue; Li, Meiying; Liu, Wenxu; Zhao, Wei; Lim, Lee Yong; Tilley, Richard D.; Gooding, J. Justin; Li, Qinghua

doi:10.1021/acsami.2c11284

Cited by 16 publications

(13 citation statements)

References 61 publications

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“…Cancer cells mostly show homotypic aggregation, and homotypic cancer cells gather together [ 84 ]. Using cancer cell membranes to fabricate drug-targeting delivery systems makes cancer cell membranes carry NPs to target cancer tissues via Thomsen–Friedenreich antigen-galectin-3 interactions [ 85 , 86 ]. However, there are drawbacks associated with this property, which limits its application to cancer cell membranes.…”

Section: Cell Membrane Types Currently Being Used To Coat Nanoparticl...mentioning

confidence: 99%

“…However, there are drawbacks associated with this property, which limits its application to cancer cell membranes. Currently, it is known that cancer-cell-membrane-coated nanoparticles are used on gliomas and metastases, as is detailed in Table 2 [ 80 , 81 , 82 , 85 , 86 , 87 , 88 , 89 , 90 ].…”

Section: Cell Membrane Types Currently Being Used To Coat Nanoparticl...mentioning

confidence: 99%

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Cell-Membrane-Coated Nanoparticles for Targeted Drug Delivery to the Brain for the Treatment of Neurological Diseases

Wei

Zhang

et al. 2023

Pharmaceutics

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Neurological diseases (NDs) are a significant cause of disability and death in the global population. However, effective treatments still need to be improved for most NDs. In recent years, cell-membrane-coated nanoparticles (CMCNPs) as drug-targeting delivery systems have become a research hotspot. Such a membrane-derived, nano drug-delivery system not only contributes to avoiding immune clearance but also endows nanoparticles (NPs) with various cellular and functional mimicries. This review article first provides an overview of the function and mechanism of single/hybrid cell-membrane-derived NPs. Then, we highlight the application and safety of CMCNPs in NDs. Finally, we discuss the challenges and opportunities in the field.

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Section: Cell Membrane Types Currently Being Used To Coat Nanoparticl...mentioning

confidence: 99%

Section: Cell Membrane Types Currently Being Used To Coat Nanoparticl...mentioning

confidence: 99%

Cell-Membrane-Coated Nanoparticles for Targeted Drug Delivery to the Brain for the Treatment of Neurological Diseases

Wei

Zhang

et al. 2023

Pharmaceutics

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“…Mo et al developed the nanoplatform based on inorganic sensitizer (NaYF 4 : Yb, Er@NaYF 4 @Zn 0.5 Cd 0.5 S) for PDT of glioblastoma. [98] With the 980 nm irradiation, the Zn 0.5 Cd 0.5 S shell can be activated through energy transfer to produce large amount of ROS, including 1 O 2 and •OH. Zhang et al constructed the pH-responsive ultrasmall Cu 2−x Se (CS) nanoparticles as inorganic sensitizer loading with DOX (CS-DOX) for orthotopic malignant glioblastoma therapy by the combination of chemotherapy and PDT.…”

Section: Photodynamic Therapymentioning

confidence: 99%

“…developed the nanoplatform based on inorganic sensitizer (NaYF 4 : Yb, Er@NaYF 4 @Zn 0.5 Cd 0.5 S) for PDT of glioblastoma. [ 98 ] With the 980 nm irradiation, the Zn 0.5 Cd 0.5 S shell can be activated through energy transfer to produce large amount of ROS, including 1 O 2 and ·OH. Zhang et al.…”

Section: Nir Light Responsive Materials For Effective Therapy Of Brai...mentioning

confidence: 99%

Advances of NIR Light Responsive Materials for Diagnosis and Treatment of Brain Diseases

Xue

Wang

Zhang

2023

Advanced Optical Materials

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Generally, brain diseases could be classified into various types. [2] The first is brain tumors, such as malignant glioblastoma, which grows invasively and destroys deep structures. The second type is brain trauma, i.e., traumatic brain injury (TBI), [3] which could cause multiple secondary injuries, including neuroinflammation, blood brain barrier (BBB) damage, and brain edema. The brain vascular diseases are an important type of brain diseases, such as strokes, which can induce a range of dysfunction due to the severe damage to the motor and sensory central nervous system (CNS). Besides, neurodegenerative diseases such as Alzheimer's disease (AD) can result in an irreversible damage to brain tissues owing to the loss of neurons and myelin sheath over time. However, due to the unclear pathogenesis and the obstacle of BBB in CNS, precise imaging diagnosis and effective therapy of brain diseases still remain a great challenge till now. [4] Hence, it is an urgent need to develop the noninvasive, efficient, and convenient techniques for precise imaging and effective therapy of brain diseases. In recent years, the optical materials have attracted great attention in the field of bioapplications, [5] but the limited penetration depth of common used excitation lights (ultraviolet or visible lights, UV-Vis) leads to their applications only in some superficial diseases, such as skin or oral tumors. [6] Currently, it has been reported that the near infrared (NIR) lights exhibit much deeper tissue penetration depth than that of UV-Vis lights, [7] especially penetrate the skull, which makes them possible for imaging and therapy of brain diseases. Hence, exploring NIR light responsive materials is a promising way for achieving precise diagnosis and efficient therapy of brain diseases. [8,9] In terms of imaging, photoacoustic (PA) imaging and the fluorescence imaging are the major imaging techniques responding to NIR lights. PA imaging integrates the advantages of NIR light and ultrasound, achieving biological imaging with deep tissue penetration depth (≈6 cm) and high contrast and resolution. [10] Besides, the lower scattering and autofluorescence of tissues in NIR region endow NIR fluorescence imaging with high sensitivity and signal-to-noise ratio (SNR). [11,12] Indocyanine green (ICG), a NIR molecule dye, was used as NIR fluorescence imaging probe in 1955 and approved by Food and Drug Administration (FDA) for clinic in 1959, but it suffered from the poor photostability and short blood circulation.

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“…In recent years, cell membrane-coated nanoparticles have been extensively investigated for biomedical applications, such as drug delivery, , immunotherapy, − biological neutralization , and phototherapy. − By combining synthetic nanoparticle cores with naturally derived cell membrane layers, they inherit the highly complex functionalities of the source cells . These biomimetic nanoparticles possess numerous favorable advantages, including high biocompatibility, reduced toxicity, and specific targeting ability .…”

Section: Introductionmentioning

confidence: 99%

Genetically Engineered Cell Membrane-Coated Nanoparticles with High-Density Customized Membrane Receptor for High-Performance Drug Lead Discovery

Bu,

Wu,

Zhao

et al. 2023

ACS Appl. Mater. Interfaces

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Cell membrane coating strategies have been increasingly researched due to their unique capabilities of biomimicry and biointerfacing, which can mimic the functionality of the original source cells in vivo but fail to provide customized nanoparticle surfaces with new or enhanced capabilities beyond natural cells. However, the field of drug lead discovery necessitates the acquisition of sufficient surface density of specific target membrane receptors, presenting a heightened demand for this technology. In this study, we developed a novel approach to fabricate high density of fibroblast growth factor receptor 4 (FGFR4) cell membrane-coated nanoparticles through covalent site-specific immobilization between genetically engineered FGFR4 with HaloTag anchor on cell membrane and chloroalkane-functionalized magnetic nanoparticles. This technique enables efficient screening of tyrosine kinase inhibitors from natural products. And the enhanced density of FGFR4 on the surface of nanoparticles were successfully confirmed by Western blot assay and confocal laser scanning microscopy. Further, the customized nanoparticles demonstrated exceptional sensitivity (limit of detection = 0.3 × 10–3 μg mL–1). Overall, the proposed design of a high density of membrane receptors, achieved through covalent site-specific immobilization with a HaloTag anchor, demonstrates a promising strategy for the development of cell membrane surface engineering. This approach highlights the potential of cell membrane coating technology for facilitating the advanced extraction of small molecules for drug discovery.

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Upconversion Nanoparticle-Based Cell Membrane-Coated cRGD Peptide Bioorthogonally Labeled Nanoplatform for Glioblastoma Treatment

Cited by 16 publications

References 61 publications

Cell-Membrane-Coated Nanoparticles for Targeted Drug Delivery to the Brain for the Treatment of Neurological Diseases

Cell-Membrane-Coated Nanoparticles for Targeted Drug Delivery to the Brain for the Treatment of Neurological Diseases

Advances of NIR Light Responsive Materials for Diagnosis and Treatment of Brain Diseases

Genetically Engineered Cell Membrane-Coated Nanoparticles with High-Density Customized Membrane Receptor for High-Performance Drug Lead Discovery

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