Synthesis and microbiological activity of some novel 5- or 6-methyl-2-(2,4-disubstituted phenyl) benzoxazole derivatives

The Reactivity of <i>Gem</i> Cyanoester Ketene Dithiolates towards the Development of Potent Antioxidant Heterocycles

“…In tetrasubstituted thiophene derivatives, the compound 7 exhibited good activity when compared with 8 and 9. It was observed that there was no marked difference in activity between gem cyanoester heterocycles (4-6) and thiophene derivatives (7)(8)(9). On the other hand, the thienothiophene derivatives 10, 11 and 12 were inactive.…”

“…Benzoxazole ring is one of the most common heterocycle in medicinal chemistry. Substituted benzoxazoles possess diverse chemotherapeutic activities including antibiotic, 8) antimicrobial [9][10][11][12][13] and antitumor. 14,15) Benzothiazole derivatives are important members of fused heterocycles as they exhibit antimicrobial properties 16) and have found applications in industry as antioxidants.…”

Structure-activity relationship of Schiff base derivatives of bis(aminophenyl)disulfide and p-vanillin as antimicrobial agents

“…Schiff bases bearing sulphur, aryl or heterocyclic groups having nitrogen are known to possess biological activities (Shi et al, 2007;Ye et. al., 2007;Chandra et al, 1997;Thangadurai and Ihm, 2004;Temiz et al, 1998). Disulfide-containing compounds are reported to possess wide variety of biological activities including anti HIV (Sharmeen et al, 2001), antibacterial (Turos et al, 2008;Bhowon et al, 2001), antifungal, inhibition of blood platelet aggregation (Okachi et al, 1985).…”

Facile and efficient one-pot synthesis of 2-arylbenzoxazoles using hydrogen tetrachloroaurate as catalyst under oxygen atmosphere

“…Benzoxazoles are an important class of heterocycles, because they have exhibited a variety of biological activities including antimicrobial and antitumor properties (Deluca and Kerwin, 1997;Temiz et al, 1998;Sato et al, 1998), thus leading them to becoming appealing targets in drug discovery (Evindar and Batey, 2006). Besides, benzoxazoles are also found applicable in material science as photochromic agents and laser dyes (Heynderickx et al, 2003;El′tsov, 1990;Trost and Flemming, 1991;Reiser et al, 1972).…”