Synthesis and molecular docking of new hydrazones derived from ethyl isonipecotate and their biological activities

Abstract

Purpose: To investigate the antibacterial and α-glucosidase inhibitory activities of hydrazone derivatives (8a-h) of ethyl isonipecotate. Methods:The reaction of ethyl isonipecotate (2) with 3,5-dichloro-2-hydroxybenzenesulfonyl chloride (1) in an aqueous basic medium yielded ethyl 1- [(3,5-dichloro-2-hydroxyphenyl)

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“…The procedure for the assay was modified from Munir et al, (2017) 19 . Alpha-glucosidase (20 μl, 1.25 u/ml) was premixed with 200 μl of samples of various concentrations and made up in a 50 mM phosphate buffer at pH 6.8 and incubated at 37 °C for 10 min.…”