Synthesis and molecular structure of a zinc complex of the vitamin K3 analogue phthiocol

Kathawate, Laxmi; Sproules, Stephen; Pawar, Omkar; Markad, Ganesh B.; Haram, Santosh K.; Puranik, Vedavati G.; Salunke‐Gawali, Sunita

doi:10.1016/j.molstruc.2013.05.057

Cited by 25 publications

(8 citation statements)

References 52 publications

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“…Vitamin A deficiency was a major nutritional deficiency disorder in many developing countries, especially affects young children, in whom it can cause xerophthalmia and lead to blindness, and can also limit growth, weaken innate and acquired host defenses, exacerbate infection and increase the risk of death [9]. Generally, metal ions were required for many critical functions in humans [10]- [12]. The ability to recognize to the molecular level and to treat diseases caused by inadequate metal-ion function constitutes an important aspect of medicinal bioinorganic chemistry [10] [12].…”

Section: Introductionmentioning

confidence: 99%

“…Generally, metal ions were required for many critical functions in humans [10]- [12]. The ability to recognize to the molecular level and to treat diseases caused by inadequate metal-ion function constitutes an important aspect of medicinal bioinorganic chemistry [10] [12]. Metal complexes have been playing a key role in the development of modern chemotherapy [13], for example, complexation of non-steroidal anti-inflammatory drugs to copper overcomes some of the gastric side effects of these drugs [14].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of Some Selenium Nanometric Compounds: Spectroscopic, Biological and Antioxidant Assessments

Atta¹,

El‐Shenawy²,

Koura³

et al. 2014

WJNSE

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Selenium (IV) vitamin A complex as antioxidant drug design was prepared and characterized by microanalysis, conductance, infrared spectra, Raman laser spectra, 1 HNMR spectra, scanning electron microscopy (SEM), X-ray powder diffraction (XRD) and thermogravimetric (TG/DTG and DTA) tool of analyses. Vitamin A chelate was coordinated as a mono-dentate ligand through the oxygen atom of -OH hydroxyl group. Thermal degradation analyses discussed the removal of terminal methyl molecules in the first and second decomposition stage while the organic ligand moieties existed in the third and subsequence steps. The Se (IV) complex in comparable with free vitamin A ligand has been assessed against some kinds of bacteria and fungi which gave a significant inhibition. The surface morphology and nano scale size of selenium metal and its vitamin complex were proved. The activation energy and other thermodynamic parameters (ΔH * , ΔS * and ΔG * ) of Se (IV) complex were calculated using Coats-Redfern and Horowitz-Metzger equations.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Some Selenium Nanometric Compounds: Spectroscopic, Biological and Antioxidant Assessments

Atta¹,

El‐Shenawy²,

Koura³

et al. 2014

WJNSE

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“…The bands observed in the visible region could be assigned to charge transfer (CT) transitions and weak n→π* transitions of the carbonyl groups in the quinone. These absorptions could be typical of aminosubtituted quinones, Also, with the formation of 4 d , (by adding a SR‐ group to 3 c ), the absorbtion band in the visible region shifted from 474 nm to 512 nm.…”

Section: Resultsmentioning

confidence: 95%

Synthesis, Electrochemistry, DFT Calculations, Antimicrobial Properties and X‐ray Crystal Structures of Some NH‐ and/or S‐ Substituted‐1,4‐quinones

et al. 2018

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The NH-, NH-,S-substituted-1,4-naphthoquinones and NH-, Ssubstituted-1,4-benzoquinones have been synthesized from the reaction between quinones (2,3-Dibromo-1,4-naphthoquinone or p-benzoquinone) and different amines. The structures of the compounds have been confirmed using FTIR, UV-Vis, 1 H-NMR, 13 C-NMR, mass MS(ESI) spectrometry and cyclic voltammetry (CV). The ground state energies of the molecules have been estimated using B3LYP functional with different basis sets based on time dependent density functional theory (TD-DFT). The theoretical ΔE gap values obtained from TD-DFT calculations have been compared with UV visible spectroscopy results. Antibacterial and antifungal activities of the synthesized compounds have been evaluated against Escherichia coli, Staphylococcus aureus and Microsporum canis, Trichophyton mentagrophytes, respectively. Two representative crystal structures of quinone derivatives, 2-(4-Fluorophenylamino)-3-bromonaphthalene-1,4-dione and 2-(3,5-Dimethylphenylthio)cyclohexa-2,5-diene-1,4-dione, are reported with CCDC 1811265 and CCDC 1811263, respectively.

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“…Generally, metal ions were required for many critical functions in humans [8][9][10]. Metal complexes have played key role in the development of modern chemotherapy [11][12][13][14], however, the study of metal-drug complexes is still in its early stages, thus representing a great challenge in current synthetic chemistry and coordination chemistry.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectroscopic Interpretations, and Antioxidant Efficiency of Two Vital Selenium Complexes

Al-Khodir

2017

Acta Phys. Pol. A

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This paper aimed to synthesis, spectroscopic characterizations, and antioxidant assessment of two new selenium complexes with nicotinamide (Nic) and riboflavin (RF) as drug chelates. The speculated structures of the synthetic selenium complexes have been discussed by using different tools of spectroscopic analyses like infrared, the Raman, electronic, 1 H-NMR, and mass. Accordingly, the Fourier transform infrared and 1 H-NMR spectra, the mode of complexation is supported, as four molecules of nicotinamide drug act as a monodentate chelate through the Natom of the pyridine ring with [Se(Nic)4]·H2O formula. The two riboflavin drug molecules coordinated to selenium metal as a bidentate chelate through azomethine nitrogen of pyrazine ring and O-atom of C=O pyrimidine-2,4-dione group with general formula [Se(RF)2]. Both of Nic and RF chelates act as neutral charge ligands. The conductivity measurements indicated that the selenium complexes are non-electrolytes behaviors. Thermal analyses (thermal gravimetric-differential thermal analysis) of the studied complexes show that the decomposition process takes place in one broadening step with a wide temperature range. The surface morphology of the mentioned complexes was studied by scanning electron microscope and the particle size is calculated using X-ray powder diffraction. Thermodynamic kinetic parameters are calculated by using the Coats and Redfern equation. Screening of antioxidant activities of selenium complexes in vitro are assessed. The antioxidant activity is studied by three methods (DPPH assay, β-carotene/linoleic acid bleaching assay, and ferric reducing power assay), the studied complexes have a significant antioxidant activity compared to synthetic antioxidants like trolox and BHT.

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Synthesis and molecular structure of a zinc complex of the vitamin K3 analogue phthiocol

Cited by 25 publications

References 52 publications

Synthesis and Characterization of Some Selenium Nanometric Compounds: Spectroscopic, Biological and Antioxidant Assessments

Synthesis and Characterization of Some Selenium Nanometric Compounds: Spectroscopic, Biological and Antioxidant Assessments

Synthesis, Electrochemistry, DFT Calculations, Antimicrobial Properties and X‐ray Crystal Structures of Some NH‐ and/or S‐ Substituted‐1,4‐quinones

Synthesis, Spectroscopic Interpretations, and Antioxidant Efficiency of Two Vital Selenium Complexes

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